The microRNAs (miRNAs) Regulating This Target |
Top |
miRNA Mature ID |
hsa-miR-145-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
guccaguuuucccaggaaucccu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The overexpression of miR-145-5p by mature miRNA precursor transfection resulted in the decreased protein level of target MYC. |
[2] |
Evidence Score (E-score) |
6 |
+ |
1 |
Immunoblot; Luciferase Reporter Assay; qRT-PCR |
[1] |
2 |
Immunoblot; Luciferase Reporter Assay; qRT-PCR |
[2] |
3 |
Luciferase Reporter Assay; qRT-PCR; Western Blot |
[3] |
4 |
Microarray; qRT-PCR; Western Blot |
[4] |
5 |
qRT-PCR; Luciferase Reporter Assay; Western Blot |
[5] |
6 |
qRT-PCR; Western Blot |
[6] |
Representative Target(s) Regulated by This miRNA |
A proliferation-inducing ligand (APRIL)
|
Target Info
|
|
Alkaline phosphatase (ALPPL2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-34a-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uggcagugucuuagcugguugu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The overexpression of miR-34a-5p by mature miRNA mimics tranfection resulted in the decreased protein level of target MYC. |
[2] |
Evidence Score (E-score) |
6 |
+ |
1 |
Luciferase Reporter Assay |
[7] |
2 |
Luciferase Reporter Assay; qRT-PCR; Western Blot |
[8] |
3 |
Luciferase Reporter Assay; Western Blot; qRT-PCR; Microarray |
[9] |
4 |
qRT-PCR; Western Blot |
[10] |
5 |
qRT-PCR; Western Blot |
[11] |
6 |
qRT-PCR; Western Blot |
[2] |
Representative Target(s) Regulated by This miRNA |
Amphiregulin (AREG)
|
Target Info
|
|
Androgen receptor (AR)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-34b-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
caaucacuaacuccacugccau
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-34b transfection decreased C-MYC protein levels. |
[14] |
Evidence Score (E-score) |
3 |
+ |
1 |
Immunohistochemistry; qRT-PCR |
[12] |
2 |
Immunoprecipitation; Luciferase Reporter Assay; Microarray; qRT-PCR; Western Blot |
[13] |
3 |
Luciferase Reporter Assay; Western Blot |
[14] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Cyclic AMP-responsive element-binding protein (CREB1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-34c-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aggcaguguaguuagcugauugc
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The overexpression of miR-34c-5p by mature miRNA mimics tranfection resulted in the decreased protein level of target MYC. |
[2] |
Evidence Score (E-score) |
3 |
+ |
1 |
Immunoprecipitation; Luciferase Reporter Assay; Microarray; qRT-PCR; Western Blot |
[13] |
2 |
Immunoprecipitation; Luciferase Reporter Assay; Microarray; qRT-PCR; Western Blot |
[2] |
3 |
Luciferase Reporter Assay |
[15] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Cyclin-dependent kinase 4 (CDK4)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-451a |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aaaccguuaccauuacugaguu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
c-Myc is identified as a direct target of miR-451. |
[16] |
Evidence Score (E-score) |
3 |
+ |
1 |
Luciferase Reporter Assay |
[16] |
2 |
Luciferase Reporter Assay |
[17] |
3 |
Luciferase Reporter Assay; qRT-PCR; Western Blot |
[18] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Extracellular signal-regulated kinase 2 (ERK2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-335-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ucaagagcaauaacgaaaaaugu
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
2 |
+ |
1 |
Microarray |
[19] |
2 |
Western Blot |
[20] |
Representative Target(s) Regulated by This miRNA |
Apoptosis inhibitor survivin (BIRC5)
|
Target Info
|
|
Apoptosis regulator Bcl-W (BCL-W)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-33b-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
gugcauugcuguugcauugc
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-33b negatively regulates c-Myc expression through direct targeting of its 3'UTR in 293T cells. |
[21] |
Evidence Score (E-score) |
2 |
+ |
1 |
Immunohistochemistry |
[21] |
2 |
Immunohistochemistry; qRT-PCR; Western Blot |
[22] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
ATP-binding cassette transporter A1 (ABCA1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-34b-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uaggcagugucauuagcugauug
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The overexpression of miR-34b-5p by mature miRNA mimics tranfection resulted in the decreased protein level of target MYC. |
[2] |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay |
[15] |
2 |
Luciferase Reporter Assay |
[2] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Beta-catenin (CTNNB1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-378a-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
acuggacuuggagucagaaggc
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
2 |
+ |
1 |
Immunoblot; Luciferase Reporter Assay; qRT-PCR |
[23] |
2 |
Immunoblot; Luciferase Reporter Assay; qRT-PCR |
[2] |
Representative Target(s) Regulated by This miRNA |
Aromatase (CYP19A1)
|
Target Info
|
|
Cyclin-dependent kinase 6 (CDK6)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-449a |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uggcaguguauuguuagcuggu
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[24] |
2 |
TRAP |
[25] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Cyclin-dependent kinase 4 (CDK4)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-98-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ugagguaguaaguuguauuguu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
E2 induced the expression of miR-98 reduced the levels of c-Myc and E2F2 proteins. |
[27] |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay; Northern Blot; qRT-PCR; ChIP |
[26] |
2 |
Microarray |
[27] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Aromatase (CYP19A1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-129-2-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aagcccuuaccccaaaaagcau
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
2 |
+ |
1 |
Immunoblot; Luciferase Reporter Assay |
[28] |
2 |
Immunoblot; Luciferase Reporter Assay |
[2] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-W (BCL-W)
|
Target Info
|
|
Cyclin-dependent kinase 6 (CDK6)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-449c-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uaggcaguguauugcuagcggcugu
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay |
[29] |
2 |
PAR-CLIP |
[30] |
Representative Target(s) Regulated by This miRNA |
Proto-oncogene c-Met (MET)
|
Target Info
|
|
Proto-oncogene c-Myc (MYC)
|
Target Info
|
|
miRNA Mature ID |
hsa-let-7c-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ugagguaguagguuguaugguu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The downregulation of let-7c-5p by Anti-miRNA Oligonucleotides resulted in the increased protein level of target MYC. |
[2] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Northern Blot; Western Blot |
[2] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-xL (BCL-xL)
|
Target Info
|
|
Caspase-3 (CASP3)
|
Target Info
|
|
miRNA Mature ID |
hsa-let-7g-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ugagguaguaguuuguacaguu
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[31] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-xL (BCL-xL)
|
Target Info
|
|
Caspase-3 (CASP3)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-106b-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uaaagugcugacagugcagau
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR |
[32] |
Representative Target(s) Regulated by This miRNA |
Amyloid beta A4 protein (APP)
|
Target Info
|
|
Apoptosis mediating surface antigen FAS (FAS)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-126-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
cauuauuacuuuugguacgcg
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
c-Myc as a target of miR-126, and miR-126 is acted as an important mediator of MMSET regulation of c-MYC. |
[33] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[33] |
Representative Target(s) Regulated by This miRNA |
Matrix metalloproteinase-7 (MMP-7)
|
Target Info
|
|
Proto-oncogene c-Crk (c-Crk)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-130a-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
cagugcaauguuaaaagggcau
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
Overexpression of miR-130a significantly reduced cmyc. |
[34] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[34] |
Representative Target(s) Regulated by This miRNA |
Activin receptor-like kinase 2 (ALK-2)
|
Target Info
|
|
Amyloid beta A4 protein (APP)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-148a-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ucagugcacuacagaacuuugu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
Direct inhibition of Myc is by miR-148a-5p. |
[35] |
Evidence Score (E-score) |
1 |
+ |
1 |
Immunoblot |
[35] |
Representative Target(s) Regulated by This miRNA |
Activated leukocyte cell adhesionmolecule (ALCAM)
|
Target Info
|
|
Activin receptor-like kinase 2 (ALK-2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-155-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uuaaugcuaaucgugauagggguu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-155 is extensively involved in the cancer pathogenesis of gastric carcinoma and support its function as recessive genes by targeting c-myc. |
[36] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[36] |
Representative Target(s) Regulated by This miRNA |
Acetyl-CoA transporter (SLC33A1)
|
Target Info
|
|
Angiotensin II receptor type-1 (AGTR1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-17-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
caaagugcuuacagugcagguag
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
c-Myc abundance was repressed by miR-17 transduction in MCF-7 cells. |
[37] |
Evidence Score (E-score) |
1 |
+ |
1 |
Western Blot |
[37] |
Representative Target(s) Regulated by This miRNA |
Amyloid beta A4 protein (APP)
|
Target Info
|
|
Apoptosis mediating surface antigen FAS (FAS)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-184 |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uggacggagaacugauaagggu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
c-Myc were the direct target of miR-184 in NPC cells. |
[38] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[38] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Platelet-derived growth factor B (PDGFB)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-185-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uggagagaaaggcaguuccuga
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR; Western Blot |
[39] |
Representative Target(s) Regulated by This miRNA |
Androgen receptor (AR)
|
Target Info
|
|
Arachidonate 12-lipoxygenase (12-LOX)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-19a-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ugugcaaaucuaugcaaaacuga
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR |
[32] |
Representative Target(s) Regulated by This miRNA |
Adrenergic receptor beta-1 (ADRB1)
|
Target Info
|
|
Apoptosis signal-regulating kinase 1 (MAP3K5)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-19b-1-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aguuuugcagguuugcauccagc
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR |
[32] |
Representative Target(s) Regulated by This miRNA |
Caspase-8 (CASP8)
|
Target Info
|
|
Fibroblast growth factor receptor 2 (FGFR2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-20a-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uaaagugcuuauagugcagguag
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
c-Myc abundance was repressed by miR-20 transduction in MCF-7 cells. |
[37] |
Evidence Score (E-score) |
1 |
+ |
1 |
Western Blot |
[37] |
Representative Target(s) Regulated by This miRNA |
Amyloid beta A4 protein (APP)
|
Target Info
|
|
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-21-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uagcuuaucagacugauguuga
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
E2 induced the expression of miR-21 reduced the levels of MYC protein. |
[26] |
Evidence Score (E-score) |
1 |
+ |
1 |
Northern Blot |
[26] |
Representative Target(s) Regulated by This miRNA |
Apoptosis antigen ligand (CD178)
|
Target Info
|
|
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-212-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uaacagucuccagucacggcc
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-212 might act on the progression of gastric cancer through the potential target gene Myc. |
[40] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[40] |
Representative Target(s) Regulated by This miRNA |
Acetylcholinesterase (AChE)
|
Target Info
|
|
Adenylate cyclase type 1 (ADCY1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-24-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uggcucaguucagcaggaacag
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The overexpression of miR-24-3p by mature miRNA mimics tranfection resulted in the decreased protein level of target MYC. |
[2] |
Evidence Score (E-score) |
1 |
+ |
1 |
Western Blot; Luciferase Reporter Assay |
[2] |
Representative Target(s) Regulated by This miRNA |
Activin receptor type IB (ACVR1B)
|
Target Info
|
|
Aurora kinase B (AURKB)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-25-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
cauugcacuugucucggucuga
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
TRAP |
[25] |
Representative Target(s) Regulated by This miRNA |
CDK inhibitor 1C p57Kip2 (CDKN1C)
|
Target Info
|
|
Cellular tumor antigen p53 (TP53)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-29a-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uagcaccaucugaaaucgguua
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miRNA-29a is a tumor suppressor that plays an important role during PRIMA-1Met-induced apoptotic signaling by targeting c-Myc. |
[41] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[41] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Aryl hydrocarbon receptor (AHR)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-324-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
cccacugccccaggugcugcugg
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR |
[42] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-xL (BCL-xL)
|
Target Info
|
|
CREB-binding protein (CREBBP)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-33a-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
gugcauuguaguugcauugca
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
Overexpression of miR-33a significantly reduced luciferase activity of the pmirGLO construct with cloned 3'UTR sequences of MYC. |
[43] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[43] |
Representative Target(s) Regulated by This miRNA |
ATP-binding cassette transporter A1 (ABCA1)
|
Target Info
|
|
ATP-binding cassette transporter B11 (ABCB11)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-34a-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
caaucagcaaguauacugcccu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-34a inhibited invasiveness of JEG-3 cells by targeting MYC. |
[44] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[44] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
Beta-catenin (CTNNB1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-373-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
gaagugcuucgauuuuggggugu
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
In Situ Hybridization; Western Blot |
[45] |
Representative Target(s) Regulated by This miRNA |
B-cell translocation gene 1 protein (BTG1)
|
Target Info
|
|
Cell surface protein HB15 (CD83)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-429 |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uaauacugucugguaaaaccgu
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
Reporter Assay; Western Blot |
[46] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
DNA [cytosine-5]-methyltransferase 1 (DNMT1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-487b-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aaucguacagggucauccacuu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-487b directly targeted MYC. |
[47] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[47] |
Representative Target(s) Regulated by This miRNA |
Metabotropic glutamate receptor 3 (mGluR3)
|
Target Info
|
|
Polycomb complex protein BMI-1 (BMI1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-494-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ugaaacauacacgggaaaccuc
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-494 is downregulated in human GC and acts as an anti-oncogene by targeting c-myc. |
[48] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[48] |
Representative Target(s) Regulated by This miRNA |
Apoptosis inhibitor survivin (BIRC5)
|
Target Info
|
|
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-92a-1-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
agguugggaucgguugcaaugcu
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR |
[32] |
Representative Target(s) Regulated by This miRNA |
Apoptosis mediating surface antigen FAS (FAS)
|
Target Info
|
|
Cellular tumor antigen p53 (TP53)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-93-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
caaagugcuguucgugcagguag
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR |
[42] |
Representative Target(s) Regulated by This miRNA |
Angiogenin (ANG)
|
Target Info
|
|
ATP-binding cassette transporter A1 (ABCA1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-25-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aggcggagacuugggcaauug
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-25 has anti-apoptosis roles in AGS cells via inhibiting FBXW7 and thus promoting oncogenes, such as CCNE1 and MYC. |
[49] |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR; Western Blot |
[49] |
Representative Target(s) Regulated by This miRNA |
G1/S-specific cyclin-E1 (CCNE1)
|
Target Info
|
|
Protein kinase C zeta (PRKCZ)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-371a-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aagugccgccaucuuuugagugu
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
In Situ Hybridization |
[45] |
Representative Target(s) Regulated by This miRNA |
Dickkopf-related protein 1 (DKK1)
|
Target Info
|
|
Proto-oncogene c-Myc (MYC)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-561-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
caaaguuuaagauccuugaagu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-561 acts as a novel tumor suppressor in gastric cancer by targeting c-Myc gene and inhibiting gastric cancer cells proliferation and invasion. |
[50] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Northern Blot; Western Blot |
[50] |
Representative Target(s) Regulated by This miRNA |
Orphan nuclear receptor DAX-1 (NR0B1)
|
Target Info
|
|
Proto-oncogene c-Myc (MYC)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-744-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ugcggggcuagggcuaacagca
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
Wild type targeting sequence of c-Myc mRNA caused a significant decrease in luciferase activity in cells transfected with miR-744. |
[51] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Immunohistochemistry; Western Blot |
[51] |
Representative Target(s) Regulated by This miRNA |
Glycogen synthase kinase-3 beta (GSK-3B)
|
Target Info
|
|
Proto-oncogene c-Myc (MYC)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-92a-2-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ggguggggauuuguugcauuac
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR |
[32] |
Representative Target(s) Regulated by This miRNA |
Apoptosis mediating surface antigen FAS (FAS)
|
Target Info
|
|
Cellular tumor antigen p53 (TP53)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-19b-2-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aguuuugcagguuugcauuuca
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR |
[32] |
Representative Target(s) Regulated by This miRNA |
Proto-oncogene c-Myc (MYC)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-599 |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
guugugucaguuuaucaaac
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
MYC (v-myc avian myelocytomatosis viral onco-gene homolog) is a target gene of hsa-miR-599. |
[52] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[52] |
Representative Target(s) Regulated by This miRNA |
Proto-oncogene c-Myc (MYC)
|
Target Info
|
|