miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-106b-5p | ||||
miRNA Stemloop AC | MI0000734 | ||||
miRNA Stemloop ID | hsa-mir-106b | ||||
Sequence | uaaagugcugacagugcagau | ||||
TTD Target(s) Regulated by This miRNA | Matrix metalloproteinase-2 (MMP-2) | Successful Target | Target Info | [1] | |
Fyn tyrosine protein kinase (FYN) | Successful Target | Target Info | [2] | ||
Amyloid beta A4 protein (APP) | Successful Target | Target Info | [3] | ||
Janus kinase 1 (JAK-1) | Successful Target | Target Info | [4] | ||
Osteoclast differentiation factor (ODF) | Successful Target | Target Info | [5] | ||
Signal transducer and activator of transcription 3 (STAT3) | Successful Target | Target Info | [6] | ||
Vascular endothelial growth factor A (VEGFA) | Successful Target | Target Info | [4] | ||
Wee1-like protein kinase (WEE1) | Clinical trial Target | Target Info | [7] | ||
Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [8] | ||
TRAIL receptor 1 (TRAIL-R1) | Clinical trial Target | Target Info | [9] | ||
Apoptosis mediating surface antigen FAS (FAS) | Clinical trial Target | Target Info | [8] | ||
G1/S-specific cyclin-D1 (CCND1) | Clinical trial Target | Target Info | [10] | ||
Caspase-7 (CASP7) | Clinical trial Target | Target Info | [4] | ||
Glucose transporter type 4 (SLC2A4) | Clinical trial Target | Target Info | [11] | ||
Hypoxia-inducible factor 1 alpha (HIF-1A) | Clinical trial Target | Target Info | [12] | ||
E2F transcription factor 1 (E2F1) | Clinical trial Target | Target Info | [13] | ||
Caspase-8 (CASP8) | Patented-recorded Target | Target Info | [14] | ||
Stress-activated protein kinase JNK2 (JNK2) | Preclinical Target | Target Info | [7] | ||
Histone acetyltransferase KAT2B (KAT2B) | Literature-reported Target | Target Info | [4] | ||
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [15] | ||
Proto-oncogene c-Myc (MYC) | Literature-reported Target | Target Info | [8] | ||
E3 ubiquitin protein ligase Itchy (ITCH) | Literature-reported Target | Target Info | [16] | ||
Lysine N-methyltransferase 3A (SETD2) | Literature-reported Target | Target Info | [17] | ||
NADPH oxidase 2 (CYBB) | Literature-reported Target | Target Info | [18] | ||
Melanoma differentiation-associated protein 6 (CDKN1A) | Literature-reported Target | Target Info | [19] | ||
Runt-related transcription factor 3 (RUNX3) | Literature-reported Target | Target Info | [20] | ||
Protein(s) Regulated by This miRNA | Adenomatous polyposis coli protein | Regulated Protein | [21] | ||
Autophagy-related protein 16-1 | Regulated Protein | [22] | |||
Bcl-2-like protein 11 | Regulated Protein | [23] | |||
Disabled homolog 2 | Regulated Protein | [24] | |||
E3 ubiquitin-protein ligase TRIM8 | Regulated Protein | [25] | |||
Eomesodermin homolog | Regulated Protein | [26] | |||
G1/S-specific cyclin-D2 | Regulated Protein | [7] | |||
Mitofusin-2 | Regulated Protein | [28] | |||
Paired mesoderm homeobox protein 1 | Regulated Protein | [29] | |||
Protein Niban | Regulated Protein | [30] | |||
Retinoblastoma-associated protein | Regulated Protein | [31] | |||
Retinoblastoma-like protein 1 | Regulated Protein | [7] | |||
Retinoblastoma-like protein 2 | Regulated Protein | [7] | |||
Rho-related GTP-binding protein RhoC | Regulated Protein | [32] | |||
Serine/threonine-protein kinase D2 | Regulated Protein | [26] | |||
Transcription elongation factor A protein-like 1 | Regulated Protein | [33] | |||
Transcription factor E2F5 | Regulated Protein | [34] | |||
Transcriptional activator protein Pur-alpha | Regulated Protein | [35] | |||
Twist-related protein 1 | Regulated Protein | [36] | |||
Zinc finger and BTB domain-containing protein 4 | Regulated Protein | [37] | |||
References | |||||
REF 1 | Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2. Cancer Sci. 2014 Jan;105(1):18-25. | ||||
REF 2 | miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease. Biochem Biophys Res Commun. 2016 Sep 16;478(2):852-7. | ||||
REF 3 | MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol. 2008 Apr;28(7):2167-74. | ||||
REF 4 | Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. Mol Cell Biol. 2007 Mar;27(6):2240-52. | ||||
REF 5 | MicroRNA-106b inhibits osteoclastogenesis and osteolysis by targeting RANKL in giant cell tumor of bone. Oncotarget. 2015 Aug 7;6(22):18980-96. | ||||
REF 6 | A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. Int J Cancer. 2015 May 1;136(9):2120-31. | ||||
REF 7 | MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC. PLoS One. 2011 Jan 20;6(1):e16138. | ||||
REF 8 | Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences. Genes Cancer. 2014 Apr;5(1-2):56-63. | ||||
REF 9 | MiR-106b inhibitors sensitize TRAIL-induced apoptosis in hepatocellular carcinoma through increase of death receptor 4. Oncotarget. 2017 Jun 27;8(26):41921-41931. | ||||
REF 10 | Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41. | ||||
REF 11 | Regulation of Insulin Resistance by Multiple MiRNAs via Targeting the GLUT4 Signalling Pathway. Cell Physiol Biochem. 2016;38(5):2063-78. | ||||
REF 12 | EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 May 2;31(9):2207-21. | ||||
REF 13 | c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005 Jun 9;435(7043):839-43. | ||||
REF 14 | MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes. Oncogene. 2014 Oct 2;33(40):4813-22. | ||||
REF 15 | MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90. | ||||
REF 16 | MicroRNA-regulated pathways associated with endometriosis. Mol Endocrinol. 2009 Feb;23(2):265-75. | ||||
REF 17 | miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma. Oncotarget. 2015 Feb 28;6(6):4066-79. | ||||
REF 18 | High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1002-H1012. | ||||
REF 19 | Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem. 2008 Jan 11;283(2):1026-33. | ||||
REF 20 | MicroRNA-106b regulates the tumor suppressor RUNX3 in laryngeal carcinoma cells. FEBS Lett. 2013 Oct 1;587(19):3166-74. | ||||
REF 21 | miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma.Carcinogenesis. 2013 Jan;34(1):211-9. | ||||
REF 22 | MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy.Gastroenterology. 2014 Jan;146(1):188-99. | ||||
REF 23 | TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC.PLoS One. 2012;7(9):e45133. | ||||
REF 24 | MicroRNA-106b is involved in transforming growth factor 1-induced cell migration by targeting disabled homolog 2 in cervical carcinoma.J Exp Clin Cancer Res. 2016 Jan 15;35:11. | ||||
REF 25 | TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours.Mol Cancer. 2017 Mar 21;16(1):67. | ||||
REF 26 | miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF- type II receptor. Brain Res. 2010 Oct 21;1357:166-74. | ||||
REF 27 | MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC. PLoS One. 2011 Jan 20;6(1):e16138. | ||||
REF 28 | MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2.Mol Cell Endocrinol. 2013 Dec 5;381(1-2):230-40. | ||||
REF 29 | Down-regualtion of miR-106b induces epithelial-mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10534-44. | ||||
REF 30 | microRNA-106b-mediated down-regulation of C1orf24 expression induces apoptosis and suppresses invasion of thyroid cancer.Oncotarget. 2015 Sep 29;6(29):28357-70. | ||||
REF 31 | Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. J Gastroenterol Hepatol. 2009 Apr;24(4):652-7. | ||||
REF 32 | Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway.PLoS One. 2015 May 1;10(5):e0125714. | ||||
REF 33 | The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer.PLoS One. 2011 Jan 20;6(1):e16221. | ||||
REF 34 | Effects of microRNA-106 on proliferation of gastric cancer cell through regulating p21 and E2F5. Asian Pac J Cancer Prev. 2013;14(5):2839-43. | ||||
REF 35 | Translation of Pur- is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection.FASEB J. 2012 Nov;26(11):4755-64. | ||||
REF 36 | MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines.Mol Carcinog. 2014 May;53(5):349-59. | ||||
REF 37 | Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters.Mol Cancer Ther. 2012 Sep;11(9):1852-62. |
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