Search Whole Database Search Prodrugs: Examples: Latanoprost; Alkaline phosphatase; Increase solubility; COX-2... Search Prodrugs by Prodrug Strategy: Please select a prodrug strategy Classical prodrug strategy Antibody-directed enzyme prodrug therapy (ADEPT) Cell-directed enzyme prodrug therapy (CDEPT) Gene-directed enzyme prodrug therapy (GDEPT) Polymer-directed enzyme prodrug therapy (PDEPT) Search Prodrugs by Bioconversion Enzyme/Condition: Please select a bioconversion enzyme/condition for prodrug activation EC 1.1: CH-OH donor oxidoreductase EC 1.2: Aldehyde/oxo donor oxidoreductase EC 1.6: NADH/NADPH oxidoreductase EC 1.8: Sulfur donor oxidoreductase EC 1.11: Peroxidase EC 1.14: Oxygen paired donor oxidoreductase EC 1.17: CH/CH2 oxidoreductase EC 2.4: Glycosyltransferase EC 2.5: Alkyl/aryl transferase EC 2.7: Kinase EC 3.1: Ester bond hydrolase EC 3.2: Glycosylase EC 3.4: Peptidase EC 3.5: Carbon-nitrogen hydrolase EC 4.1: Carbon-carbon lyase EC 4.4: Carbon-sulfur lyase Others: Acid environment Others: Glutathione Others: Light irradiation Others: Physiological condition Search Prodrugs by Improved Property: Please select an improved property on prodrug Achieve targeted delivery Control drug release Enhance patient compliance Generate synergistic effect Improve oral absorption Improve stability Improve tolerability Increase lipophilicity Increase oral absorption Increase solubility Minimize side effect/toxicity Overcome drug resistance Prolong duration of action Shorten onset of action Shorten time of activation Search Prodrugs by Target Name: Please select a target Acetylcholinesterase (AChE) Adenosine A2a receptor (ADORA2A) Adrenergic receptor beta-1 (ADRB1) Adrenergic receptor beta-2 (ADRB2) Androgen receptor (AR) Angiotensin II receptor type-1 (AGTR1) Angiotensin-converting enzyme (ACE) Aryl hydrocarbon receptor (AHR) Bacterial Fatty acid synthetase I (Bact inhA) Checkpoint kinase-1 (CHK1) Cyclin-dependent kinase 9 (CDK9) DNA topoisomerase I (TOP1) DNA topoisomerase II alpha (TOP2A) Dopamine D1 receptor (D1R) Dopamine D2 receptor (D2R) Dopamine transporter (DAT) Epidermal growth factor receptor (EGFR) Erbb2 tyrosine kinase receptor (HER2) Estrogen receptor (ESR) Fibroblast growth factor receptor 1 (FGFR1) Glucocorticoid receptor (NR3C1) Histamine H1 receptor (H1R) Histamine H2 receptor (H2R) Histone deacetylase 1 (HDAC1) Histone deacetylase 2 (HDAC2) HMG-CoA reductase (HMGCR) Human immunodeficiency virus Protease (HIV PR) Matrix metalloproteinase-2 (MMP-2) Matrix metalloproteinase-9 (MMP-9) Melanin-concentrating hormone receptor 1 (MCHR1) Metabotropic glutamate receptor 2 (mGluR2) Metabotropic glutamate receptor 3 (mGluR3) Neutral endopeptidase (MME) Nicotinamide phosphoribosyltransferase (NAMPT) Opioid receptor delta (OPRD1) Opioid receptor kappa (OPRK1) Opioid receptor mu (MOP) Parathyroid hormone (PTH) Peroxisome proliferator-activated receptor alpha (PPARA) PI3-kinase alpha (PIK3CA) Progesterone receptor (PGR) Prostacyclin receptor (PTGIR) Prostaglandin F2-alpha receptor (PTGFR) Prostaglandin G/H synthase 1 (COX-1) Prostaglandin G/H synthase 2 (COX-2) Proteasome beta-5 (PS beta-5) Retinoic acid receptor beta (RARB) Retinoic acid receptor gamma (RARG) Sodium/glucose cotransporter 2 (SGLT2) Thymidylate synthase (TYMS) Toll-like receptor 7 (TLR7) Vascular endothelial growth factor receptor 2 (KDR) Vitamin D3 receptor (VDR) Xanthine dehydrogenase/oxidase (XDH) Search Prodrugs by Target Family: Please select a target family Carbon-nitrogen hydrolase Carboxylic ester hydrolase CH-CH donor oxidoreductase CH-OH donor oxidoreductase CH/CH(2) oxidoreductase Glycosylase Glycosyltransferases GPCR glutamate GPCR rhodopsin Kinase Methyltransferase Neurotransmitter:sodium symporter Nuclear hormone receptor Paired donor oxygen oxidoreductase Peptidase Solute:sodium symporter Toll-like receptor Topoisomerase Search Prodrugs by ICD-11 Defined Disease Class: Please select a disease class 1A00-1C4Z: Bacterial infection 1B10-1B12: Tuberculosis 1B5Y: Staphylococcal/streptococcal disease 1C60-1C62: Human immunodeficiency virus disease 1D6YCoronavirus Disease 2019 1E30-1E32: Influenza 1E50-1E51: Hepatitis virus infection 1E91: Zoster 1F00: Herpes simplex infection 1F20: Aspergillosis 1F23: Candidosis 1F29-1F2F: Fungal infection 1F2C: Mucormycosis 1F40-1F45: Malaria 1F51: African trypanosomiasis 1F53: Chagas disease 2A00-2F9Z: Solid tumour/cancer 2A00: Brain cancer 2A82: Mature B-cell leukaemia 2A83: Multiple myeloma 2A85: Mature B-cell lymphoma 2A86: B-cell lymphoma 2A90: Mature T-cell lymphoma 2B30: Hodgkin lymphoma 2B33: Malignant haematopoietic neoplasm 2B51: Osteosarcoma 2B57: Kaposi sarcoma 2B90: Colon cancer 2B91: Colorectal cancer 2C00: Anal cancer 2C10: Pancreatic cancer 2C12: Liver cancer 2C25: Lung cancer 2C30: Melanoma 2C60-2C6Y: Breast cancer 2C73: Ovarian cancer 2C80: Testicular cancer 2C82: Prostate cancer 2C94: Bladder cancer 2D11: Adrenal cancer 4B24: Graft-versus-host disease 5A11: Type 2 diabetes mellitus 5A50: Hypo-parathyroidism 5A51: Hyper-parathyroidism 5A60-5A61: Pituitary gland disorder 5B80-5B81: Obesity 5C50: Metabolism inborn error 5C55: Inborn purine/pyrimidine/nucleotide metabolism error 5C80: Hyper-lipoproteinaemia 6A05: Attention deficit hyperactivity disorder 6A20: Schizophrenia 6A70-6A7Z: Depression 6B00-6B0Z: Anxiety disorder 6B82: Binge eating disorder 7A80: Restless legs syndrome 8A00: Parkinsonism 8A01: Choreiform disorder 8A02: Dystonic disorder 8A04: Tremor-related disorder 8A20: Alzheimer disease 8A40: Multiple sclerosis 8A61-8A6Z: Epilepsy/seizure 8B10-8B11: Ischemia 8B60: Motor neuron disease 8B82: Trigeminal nerve disorder 8C70: Muscular dystrophy 9A60: Conjunctiva disorder 9B72: Retinal inflammation 9C61: Glaucoma AA00-AA13: Otitis externa AA80-AB0Z: Otitis media BA00-BA04: Hypertension BA21: Orthostatic hypotension BA40: Angina pectoris BA41-BA43: Myocardial infarction BB00: Pulmonary thromboembolism BB01: Pulmonary hypertension BC81: Supraventricular tachyarrhythmia BD10-BD1Z: Heart failure BD71: Deep vein thrombosis BD72: Venous thromboembolism CA00: Nasopharyngitis CA08: Vasomotor/allergic rhinitis CA0A: Chronic rhinosinusitis CA22: Chronic obstructive pulmonary disease CA23: Asthma CA40: Pneumonia DA22: Gastro-oesophageal reflux disease DA90: Diarrhea DD71: Ulcerative colitis DD72: Indeterminate colitis EA90: Psoriasis EB00: Spontaneous urticaria ED80: Acne vulgaris FA00-FA05: Osteoarthritis FA20: Rheumatoid arthritis FA25: Gout FB84: Osteomyelitis/osteitis GA6Z: Female genital system disease GC08: Urinary tract infection GC50: Functional bladder disorder MD90: Nausea/vomiting MG30: Chronic pain
