miRNA General Information
miRNA Mature ID hsa-miR-184
miRNA Stemloop AC MI0000481
miRNA Stemloop ID hsa-mir-184
Sequence uggacggagaacugauaagggu
TTD Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [1]
RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Target Info [2]
Protein kinase C beta (PRKCB) Clinical trial Target Target Info [2]
Platelet-derived growth factor B (PDGFB) Clinical trial Target Target Info [3]
Pyruvate kinase M2 (PKM) Clinical trial Target Target Info [4]
Proto-oncogene c-Myc (MYC) Literature-reported Target Target Info [1]
RAC-beta serine/threonine-protein kinase (AKT2) Literature-reported Target Target Info [5]
Protein(s) Regulated by This miRNA Bridging integrator 3 Regulated Protein [2]
Ezrin Regulated Protein [7]
Growth arrest-specific protein 1 Regulated Protein [8]
Nuclear factor of activated T-cells, cytoplasmic 2 Regulated Protein [9]
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Regulated Protein [10]
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Regulated Protein [11]
Phospholipid phosphatase 3 Regulated Protein [3]
Protein argonaute-2 Regulated Protein [13]
RelA-associated inhibitor Regulated Protein [14]
Staphylococcal nuclease domain-containing protein 1 Regulated Protein [15]
Transcription factor SOX-7 Regulated Protein [16]
Tumor necrosis factor alpha-induced protein 2 Regulated Protein [17]
Zinc finger protein ZFPM2 Regulated Protein [3]
References
REF 1 Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma. Cell Death Dis. 2013 Oct 24;4:e872.
REF 2 Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis - Influence on microglial function. Sci Rep. 2016 Sep 26;6:33943.
REF 3 miR-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. FASEB J. 2017 Jan;31(1):256-265.
REF 4 c-Myc modulates glucose metabolism via regulation of miR-184/PKM2 pathway in clear-cell renal cell carcinoma. Int J Oncol. 2016 Oct;49(4):1569-75.
REF 5 Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest. 2010 Feb;90(2):144-55.
REF 6 Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis - Influence on microglial function. Sci Rep. 2016 Sep 26;6:33943.
REF 7 miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration.FEBS J. 2014 Dec;281(23):5251-64.
REF 8 MiR-184 Regulates Proliferation in Nucleus Pulposus Cells by Targeting GAS1.World Neurosurg. 2017 Jan;97:710-715.e1.
REF 9 microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells.Blood. 2009 Jun 25;113(26):6648-57.
REF 10 MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia.Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19300-5.
REF 11 miR-184 functions as an oncogenic regulator in hepatocellular carcinoma (HCC).Biomed Pharmacother. 2014 Mar;68(2):143-8.
REF 12 miR-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. FASEB J. 2017 Jan;31(1):256-265.
REF 13 Argonaute2 mediates compensatory expansion of the pancreatic cell.Cell Metab. 2014 Jan 7;19(1):122-34.
REF 14 MicroRNA-184 Modulates Human Central Nervous System Lymphoma Cells Growth and Invasion by Targeting iASPP.J Cell Biochem. 2017 Sep;118(9):2645-2653.
REF 15 Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness.Neuro Oncol. 2015 Mar;17(3):419-29.
REF 16 Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma.PLoS One. 2014 Feb 18;9(2):e88796.
REF 17 MicroRNA-184 inhibits cell proliferation and invasion, and specifically targets TNFAIP2 in Glioma.J Exp Clin Cancer Res. 2015 Mar 26;34:27.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.