miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-19a-3p | ||||
miRNA Stemloop AC | MI0000073 | ||||
miRNA Stemloop ID | hsa-mir-19a | ||||
Sequence | ugugcaaaucuaugcaaaacuga | ||||
TTD Target(s) Regulated by This miRNA | Arachidonate 5-lipoxygenase (5-LOX) | Successful Target | Target Info | [1] | |
Erbb4 tyrosine kinase receptor (Erbb-4) | Successful Target | Target Info | [2] | ||
Estrogen receptor (ESR) | Successful Target | Target Info | [3] | ||
Tyrosine-protein kinase Kit (KIT) | Successful Target | Target Info | [4] | ||
PI3-kinase alpha (PIK3CA) | Successful Target | Target Info | [5] | ||
ATP-binding cassette transporter A1 (ABCA1) | Successful Target | Target Info | [6] | ||
B-cell receptor CD22 (CD22) | Successful Target | Target Info | [7] | ||
Tumor necrosis factor (TNF) | Successful Target | Target Info | [8] | ||
Adrenergic receptor beta-1 (ADRB1) | Successful Target | Target Info | [9] | ||
Toll-like receptor 7 (TLR7) | Successful Target | Target Info | [10] | ||
Dihydropyrimidinase related protein 2 (DPYSL2) | Successful Target | Target Info | [11] | ||
RAC-alpha serine/threonine-protein kinase (AKT1) | Successful Target | Target Info | [12] | ||
DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | Target Info | [13] | ||
Apoptosis signal-regulating kinase 1 (MAP3K5) | Clinical trial Target | Target Info | [14] | ||
G1/S-specific cyclin-D1 (CCND1) | Clinical trial Target | Target Info | [15] | ||
Interleukin-10 (IL10) | Clinical trial Target | Target Info | [16] | ||
TGF-beta receptor type II (TGFBR2) | Clinical trial Target | Target Info | [17] | ||
TNF superfamily receptor 12A (TNFRSF12A) | Clinical trial Target | Target Info | [18] | ||
Toll-like receptor 2 (TLR2) | Clinical trial Target | Target Info | [19] | ||
Protein arginine methyltransferase 5 (PRMT5) | Clinical trial Target | Target Info | [20] | ||
Transferrin (TF) | Clinical trial Target | Target Info | [21] | ||
Thrombospondin-1 (THBS1) | Clinical trial Target | Target Info | [22] | ||
Tumor suppressor candidate 2 (TUSC2) | Clinical trial Target | Target Info | [23] | ||
Bone morphogenetic protein receptor (BMPR2) | Literature-reported Target | Target Info | [24] | ||
Histone acetyltransferase KAT2B (KAT2B) | Literature-reported Target | Target Info | [24] | ||
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [25] | ||
Proto-oncogene c-Myc (MYC) | Literature-reported Target | Target Info | [26] | ||
Zinc finger protein A20 (TNFAIP3) | Literature-reported Target | Target Info | [18] | ||
Orphan nuclear receptor NURR1 (NR4A2) | Literature-reported Target | Target Info | [2] | ||
Homeobox protein Hox-A5 (HOXA5) | Literature-reported Target | Target Info | [25] | ||
Methyl cpg binding protein 2 (MECP2) | Clinical trial Target | Target Info | [25] | ||
N-myc proto-oncogene protein (MYCN) | Literature-reported Target | Target Info | [25] | ||
Suppressor of cytokine signaling 1 (SOCS1) | Literature-reported Target | Target Info | [24] | ||
Suppressor of cytokine signaling 3 (SOCS3) | Literature-reported Target | Target Info | [18] | ||
Protein(s) Regulated by This miRNA | Apoptosis regulatory protein Siva | Regulated Protein | [23] | ||
Ataxin-1 | Regulated Protein | [28] | |||
Bcl-2-like protein 11 | Regulated Protein | [24] | |||
Cullin-5 | Regulated Protein | [30] | |||
E3 ubiquitin-protein ligase ARIH2 | Regulated Protein | [31] | |||
Forkhead box protein P1 | Regulated Protein | [23] | |||
Homeobox protein PKNOX1 | Regulated Protein | [32] | |||
Max dimerization protein 1 | Regulated Protein | [33] | |||
Methylsterol monooxygenase 1 | Regulated Protein | [6] | |||
Microtubule-associated tumor suppressor 1 | Regulated Protein | [35] | |||
Mothers against decapentaplegic homolog 4 | Regulated Protein | [36] | |||
Myocyte-specific enhancer factor 2D | Regulated Protein | [37] | |||
PH domain leucine-rich repeat-containing protein phosphatase 1 | Regulated Protein | [38] | |||
Polycomb protein SUZ12 | Regulated Protein | [6] | |||
Probable aminopeptidase NPEPL1 | Regulated Protein | [39] | |||
Prosaposin | Regulated Protein | [6] | |||
Protein TMEPAI | Regulated Protein | [40] | |||
Ras-related protein Rab-13 | Regulated Protein | [6] | |||
Ras-related protein Rab-14 | Regulated Protein | [41] | |||
Rho-related GTP-binding protein RhoB | Regulated Protein | [42] | |||
Tumor protein p53-inducible nuclear protein 1 | Regulated Protein | [23] | |||
Vacuolar protein sorting-associated protein 4B | Regulated Protein | [25] | |||
Zinc finger and BTB domain-containing protein 4 | Regulated Protein | [44] | |||
References | |||||
REF 1 | 5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p. J Immunol. 2015 Feb 15;194(4):1646-53. | ||||
REF 2 | Identification of microRNAs regulated by activin A in human embryonic stem cells. J Cell Biochem. 2010 Jan 1;109(1):93-102. | ||||
REF 3 | The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol. 2007 May;21(5):1132-47. | ||||
REF 4 | Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia. Haematologica. 2011 Dec;96(12):1783-91. | ||||
REF 5 | Downregulation of miR-19a exhibits inhibitory effects on metastatic renal cell carcinoma by targeting PIK3CA and inactivating Notch signaling in vitro. Oncol Rep. 2015 Aug;34(2):739-46. | ||||
REF 6 | Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer. PLoS One. 2013;8(2):e56592. | ||||
REF 7 | The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop. Blood. 2013 Dec 19;122(26):4220-9. | ||||
REF 8 | TNF- is a novel target of miR-19a. Int J Oncol. 2011 Apr;38(4):1013-22. | ||||
REF 9 | MiR-19a overexpression contributes to heart failure through targeting ADRB1. Int J Clin Exp Med. 2015 Jan 15;8(1):642-9. | ||||
REF 10 | Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A. Blood. 2015 Aug 6;126(6):766-78. | ||||
REF 11 | Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma. Br J Cancer. 2011 Jul 12;105(2):296-303. | ||||
REF 12 | MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. Int J Clin Exp Pathol. 2014 Sep 15;7(10):7286-96. | ||||
REF 13 | Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med. 2013 Feb 15;187(4):397-405. | ||||
REF 14 | MicroRNA-19a regulates lipopolysaccharide-induced endothelial cell apoptosis through modulation of apoptosis signal-regulating kinase 1 expression. BMC Mol Biol. 2015 May 16;16:11. | ||||
REF 15 | MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res. 2008 May;18(5):549-57. | ||||
REF 16 | Micro RNA-19a suppresses interleukin-10 in peripheral B cells of patients with diabetic retinopathy. Am J Transl Res. 2017 Mar 15;9(3):1410-1417. | ||||
REF 17 | MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1553-8. | ||||
REF 18 | EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 May 2;31(9):2207-21. | ||||
REF 19 | TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes. J Immunol. 2012 Jan 1;188(1):454-61. | ||||
REF 20 | Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. Mol Cell Biol. 2008 Oct;28(20):6262-77. | ||||
REF 21 | MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. Mol Cell Biochem. 2013 Aug;380(1-2):239-47. | ||||
REF 22 | Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet. 2005 Dec 15;14(24):3813-21. | ||||
REF 23 | Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression. PLoS One. 2015 Sep 14;10(9):e0137887. | ||||
REF 24 | MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90. | ||||
REF 25 | Prediction of mammalian microRNA targets. Cell. 2003 Dec 26;115(7):787-98. | ||||
REF 26 | Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences. Genes Cancer. 2014 Apr;5(1-2):56-63. | ||||
REF 27 | Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression. PLoS One. 2015 Sep 14;10(9):e0137887. | ||||
REF 28 | miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.Nat Neurosci. 2008 Oct;11(10):1137-9. | ||||
REF 29 | MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90. | ||||
REF 30 | MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5.Cancer Lett. 2012 Sep 28;322(2):148-58. | ||||
REF 31 | Aberration of blastocyst microRNA expression is associated with human infertility.Fertil Steril. 2010 May 1;93(7):2374-82. | ||||
REF 32 | The miR-17 2 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.Leuk Res. 2016 Jul;46:51-60. | ||||
REF 33 | MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1.Cell Death Dis. 2014 Mar 27;5:e1144. | ||||
REF 34 | Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer. PLoS One. 2013;8(2):e56592. | ||||
REF 35 | Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer.Protein Cell. 2017 Jun;8(6):455-466. | ||||
REF 36 | The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res. 2010 Oct 15;70(20):8233-46. | ||||
REF 37 | MEF2D/Wnt/-catenin pathway regulates the proliferation of gastric cancer cells and is regulated by microRNA-19.Tumour Biol. 2016 Jul;37(7):9059-69. | ||||
REF 38 | The miRNA-17 2 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation.Leukemia. 2012 May;26(5):1064-72. | ||||
REF 39 | Novel direct targets of miR-19a identified in breast cancer cells by a quantitative proteomic approach.PLoS One. 2012;7(8):e44095. | ||||
REF 40 | miR 9a p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion.Mol Med Rep. 2016 May;13(5):4030-8. | ||||
REF 41 | Identification of direct targets for the miR-17-92 cluster by proteomic analysis. Proteomics. 2011 Sep;11(17):3531-9. | ||||
REF 42 | MiR-19a promotes cell proliferation and invasion by targeting RhoB in human glioma cells.Neurosci Lett. 2016 Aug 15;628:161-6. | ||||
REF 43 | Prediction of mammalian microRNA targets. Cell. 2003 Dec 26;115(7):787-98. | ||||
REF 44 | Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nat Commun. 2013;4:2730. |
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