miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-93-5p | ||||
miRNA Stemloop AC | MI0000095 | ||||
miRNA Stemloop ID | hsa-mir-93 | ||||
Sequence | caaagugcuguucgugcagguag | ||||
TTD Target(s) Regulated by This miRNA | ATP-binding cassette transporter A1 (ABCA1) | Successful Target | Target Info | [1] | |
Interleukin-8 (IL8) | Successful Target | Target Info | [2] | ||
Intercellular adhesion molecule ICAM-1 (ICAM1) | Successful Target | Target Info | [3] | ||
Transforming growth factor beta 1 (TGFB1) | Successful Target | Target Info | [3] | ||
Vascular endothelial growth factor A (VEGFA) | Successful Target | Target Info | [4] | ||
Monoglyceride lipase (MAGL) | Clinical trial Target | Target Info | [5] | ||
TGF-beta receptor type II (TGFBR2) | Clinical trial Target | Target Info | [6] | ||
Epiregulin (EREG) | Clinical trial Target | Target Info | [5] | ||
Glucose transporter type 4 (SLC2A4) | Clinical trial Target | Target Info | [7] | ||
Hypoxia-inducible factor 1 alpha (HIF-1A) | Clinical trial Target | Target Info | [8] | ||
E2F transcription factor 1 (E2F1) | Clinical trial Target | Target Info | [9] | ||
Tumor suppressor candidate 2 (TUSC2) | Clinical trial Target | Target Info | [10] | ||
Matrix metalloproteinase-3 (MMP-3) | Patented-recorded Target | Target Info | [4] | ||
Stress-activated protein kinase JNK2 (JNK2) | Preclinical Target | Target Info | [11] | ||
Angiogenin (ANG) | Literature-reported Target | Target Info | [12] | ||
Histone acetyltransferase KAT2B (KAT2B) | Literature-reported Target | Target Info | [13] | ||
Large tumor suppressor homolog 2 (LATS2) | Literature-reported Target | Target Info | [14] | ||
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [15] | ||
Proto-oncogene c-Myc (MYC) | Literature-reported Target | Target Info | [3] | ||
Integrin beta-8 (ITGB8) | Clinical trial Target | Target Info | [16] | ||
Melanoma differentiation-associated protein 6 (CDKN1A) | Literature-reported Target | Target Info | [17] | ||
Protein(s) Regulated by This miRNA | Autophagy-related protein 16-1 | Regulated Protein | [18] | ||
Cdc42-interacting protein 4 | Regulated Protein | [5] | |||
Ceramide synthase 2 | Regulated Protein | [20] | |||
Disabled homolog 2 | Regulated Protein | [21] | |||
E3 ubiquitin-protein ligase ZNRF3 | Regulated Protein | [22] | |||
Forkhead box protein O3 | Regulated Protein | [23] | |||
Hepatocyte nuclear factor 3-alpha | Regulated Protein | [24] | |||
HLA class I histocompatibility antigen, alpha chain F | Regulated Protein | [3] | |||
Max dimerization protein 1 | Regulated Protein | [5] | |||
Methylsterol monooxygenase 1 | Regulated Protein | [5] | |||
Monocarboxylate transporter 9 | Regulated Protein | [5] | |||
Neuronal PAS domain-containing protein 2 | Regulated Protein | [5] | |||
NF-kappa-B inhibitor alpha | Regulated Protein | [26] | |||
PH domain leucine-rich repeat-containing protein phosphatase 2 | Regulated Protein | [23] | |||
Programmed cell death protein 4 | Regulated Protein | [27] | |||
Protein Wnt-2b | Regulated Protein | [3] | |||
Rab11 family-interacting protein 1 | Regulated Protein | [28] | |||
Rho-related GTP-binding protein RhoC | Regulated Protein | [29] | |||
Ribosomal protein S6 kinase alpha-4 | Regulated Protein | [30] | |||
SAM and SH3 domain-containing protein 1 | Regulated Protein | [5] | |||
Serine/threonine-protein kinase STK11 | Regulated Protein | [31] | |||
Sorting nexin-16 | Regulated Protein | [5] | |||
Sorting nexin-9 | Regulated Protein | [5] | |||
Transcriptional activator protein Pur-alpha | Regulated Protein | [32] | |||
Tumor protein p53-inducible nuclear protein 1 | Regulated Protein | [33] | |||
Zinc finger and BTB domain-containing protein 4 | Regulated Protein | [34] | |||
References | |||||
REF 1 | Up-regulated miR-93 contributes to coronary atherosclerosis pathogenesis through targeting ABCA1. Int J Clin Exp Med. 2015 Jan 15;8(1):674-81. | ||||
REF 2 | Expression of microRNA-93 and Interleukin-8 during Pseudomonas aeruginosa-mediated induction of proinflammatory responses. Am J Respir Cell Mol Biol. 2014 Jun;50(6):1144-55. | ||||
REF 3 | Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. PLoS One. 2013 Dec 19;8(12):e84486. | ||||
REF 4 | Down regulation of MiR-93 contributes to endometriosis through targeting MMP3 and VEGFA. Am J Cancer Res. 2015 Apr 15;5(5):1706-17. | ||||
REF 5 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 6 | Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41. | ||||
REF 7 | miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance. Diabetes. 2013 Jul;62(7):2278-86. | ||||
REF 8 | EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 May 2;31(9):2207-21. | ||||
REF 9 | c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005 Jun 9;435(7043):839-43. | ||||
REF 10 | miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1. Mol Cancer Res. 2009 Aug;7(8):1234-43. | ||||
REF 11 | MiR-205 silences MED1 in hypoxic primary human trophoblasts. FASEB J. 2010 Jun;24(6):2030-9. | ||||
REF 12 | miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin. Cancer Lett. 2012 Oct 28;323(2):171-9. | ||||
REF 13 | MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90. | ||||
REF 14 | MiR-93 enhances angiogenesis and metastasis by targeting LATS2. Cell Cycle. 2012 Dec 1;11(23):4352-65. | ||||
REF 15 | Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells. FEBS Lett. 2012 May 7;586(9):1279-86. | ||||
REF 16 | MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-8. Oncogene. 2011 Feb 17;30(7):806-21. | ||||
REF 17 | Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem. 2008 Jan 11;283(2):1026-33. | ||||
REF 18 | MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy.Gastroenterology. 2014 Jan;146(1):188-99. | ||||
REF 19 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 20 | Repression of the miR-93-enhanced sensitivity of bladder carcinoma to chemotherapy involves the regulation of LASS2.Onco Targets Ther. 2016 Mar 29;9:1813-22. | ||||
REF 21 | miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.Oncogene. 2014 Aug 21;33(34):4307-15. | ||||
REF 22 | ZNRF3 contributes to the growth of lung carcinoma via inhibiting Wnt/-catenin pathway and is regulated by miR-93.Tumour Biol. 2016 Mar;37(3):3051-7. | ||||
REF 23 | miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway. Oncotarget. 2015 Apr 10;6(10):8286-99. | ||||
REF 24 | MicroRNA-93 Promotes Epithelial-Mesenchymal Transition of Endometrial Carcinoma Cells.PLoS One. 2016 Nov 9;11(11):e0165776. | ||||
REF 25 | Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. PLoS One. 2013 Dec 19;8(12):e84486. | ||||
REF 26 | Bioinformatic analysis of microRNA and mRNA Regulation in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease.Respir Res. 2017 Jan 5;18(1):4. | ||||
REF 27 | miR-93 functions as an oncomiR for the downregulation of PDCD4 in gastric carcinoma.Sci Rep. 2016 Mar 29;6:23772. | ||||
REF 28 | Micro ribonucleic acid-93 promotes oncogenesis of cervical cancer by targeting RAB11 family interacting protein 1.J Obstet Gynaecol Res. 2016 Sep;42(9):1168-79. | ||||
REF 29 | RhoC is a major target of microRNA-93-5P in epithelial ovarian carcinoma tumorigenesis and progression.Mol Cancer. 2015 Feb 4;14:31. | ||||
REF 30 | miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.Nat Commun. 2016 Jun 28;7:12076. | ||||
REF 31 | MiR-93 Promotes Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer Cells by Activating the PI3K/Akt Pathway via Inhibition of LKB1/PTEN/CDKN1A.J Cancer. 2017 Mar 7;8(5):870-879. | ||||
REF 32 | Translation of Pur- is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection.FASEB J. 2012 Nov;26(11):4755-64. | ||||
REF 33 | Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1.Cancer Res. 2008 Nov 1;68(21):8976-85. | ||||
REF 34 | Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters.Mol Cancer Ther. 2012 Sep;11(9):1852-62. |
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