miRNA General Information
miRNA Mature ID hsa-miR-126-5p
miRNA Stemloop AC MI0000471
miRNA Stemloop ID hsa-mir-126
Sequence cauuauuacuuuugguacgcg
TTD Target(s) Regulated by This miRNA Matrix metalloproteinase-7 (MMP-7) Successful Target Target Info [1]
Vascular endothelial growth factor A (VEGFA) Successful Target Target Info [2]
Stromal cell-derived factor 1 (CXCL12) Clinical trial Target Target Info [3]
Proto-oncogene c-Myc (MYC) Literature-reported Target Target Info [4]
Proto-oncogene c-Crk (c-Crk) Literature-reported Target Target Info [5]
Protein(s) Regulated by This miRNA Disintegrin and metalloproteinase domain-containing protein 9 Regulated Protein [1]
Solute carrier family 45 member 3 Regulated Protein [7]
Sprouty-related, EVH1 domain-containing protein 1 Regulated Protein [8]
Tyrosine-protein phosphatase non-receptor type 7 Regulated Protein [9]
Ubiquitin carboxyl-terminal hydrolase CYLD Regulated Protein [10]
References
REF 1 miR-126&126* restored expressions play a tumor suppressor role by directly regulating ADAM9 and MMP7 in melanoma. PLoS One. 2013;8(2):e56824.
REF 2 Down-regulation of microRNA-126-5p contributes to overexpression of VEGFA in lipopolysaccharide-induced acute lung injury. Biotechnol Lett. 2016 Aug;38(8):1277-84.
REF 3 miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol. 2013 Mar;15(3):284-94.
REF 4 MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC. Leukemia. 2013 Mar;27(3):686-94.
REF 5 Overexpression of miR-126 inhibits the activation and migration of HSCs through targeting CRK. Cell Physiol Biochem. 2014;33(1):97-106.
REF 6 miR-126&126* restored expressions play a tumor suppressor role by directly regulating ADAM9 and MMP7 in melanoma. PLoS One. 2013;8(2):e56824.
REF 7 Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells.J Mol Med (Berl). 2008 Mar;86(3):313-22.
REF 8 Lipoxin A4 stimulates endothelial miR-126-5p expression and its transfer via microvesicles.FASEB J. 2017 May;31(5):1856-1866.
REF 9 Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.Blood. 2011 Feb 17;117(7):2157-65.
REF 10 MicroRNA miR-126-5p Enhances the Inflammatory Responses of Monocytes to Lipopolysaccharide Stimulation by Suppressing Cylindromatosis in Chronic HIV-1 Infection.J Virol. 2017 Apr 28;91(10). pii: e02048-16.

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