miRNA General Information
miRNA Mature ID hsa-miR-25-3p
miRNA Stemloop AC MI0000082
miRNA Stemloop ID hsa-mir-25
Sequence cauugcacuugucucggucuga
TTD Target(s) Regulated by This miRNA Erbb2 tyrosine kinase receptor (HER2) Successful Target Target Info [1]
Dihydrofolate reductase (DHFR) Successful Target Target Info [2]
Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Target Info [3]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [4]
Enhancer of zeste homolog 2 (EZH2) Successful Target Target Info [5]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) Clinical trial Target Target Info [6]
TNF related apoptosis inducing ligand (TNFSF10) Clinical trial Target Target Info [7]
Collagen I (COL1A2) Clinical trial Target Target Info [8]
Protein arginine methyltransferase 5 (PRMT5) Clinical trial Target Target Info [9]
Kruppel like factor 4 (KLF4) Clinical trial Target Target Info [10]
Cytochrome P450 2B6 (CYP2B6) Literature-reported Target Target Info [11]
Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Target Info [12]
Large tumor suppressor homolog 2 (LATS2) Literature-reported Target Target Info [13]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [14]
Proto-oncogene c-Myc (MYC) Literature-reported Target Target Info [15]
Epithelial cadherin (CDH1) Literature-reported Target Target Info [16]
F-box and WD-40 domain protein 7 (Fbxw7) Literature-reported Target Target Info [17]
CDK inhibitor 1C p57Kip2 (CDKN1C) Literature-reported Target Target Info [18]
Suppressor of tumorigenicity 15 protein (ST15) Literature-reported Target Target Info [19]
Protein(s) Regulated by This miRNA Bcl-2-like protein 11 Regulated Protein [20]
C-C motif chemokine 26 Regulated Protein [3]
Cytoplasmic polyadenylation element-binding protein 1 Regulated Protein [22]
Desmocollin-2 Regulated Protein [23]
DNA polymerase zeta catalytic subunit Regulated Protein [24]
Dual specificity mitogen-activated protein kinase kinase 4 Regulated Protein [7]
Heart- and neural crest derivatives-expressed protein 2 Regulated Protein [26]
Regulator of G-protein signaling 3 Regulated Protein [27]
Semaphorin-4C Regulated Protein [28]
Transcription elongation factor A protein-like 1 Regulated Protein [29]
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 Regulated Protein [30]
References
REF 1 MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival. Oncogene. 2015 May 14;34(20):2556-65.
REF 2 A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer. J Biol Chem. 2017 Mar 24;292(12):4873-4884.
REF 3 MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5316-21.
REF 4 Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene. 2011 Feb 17;30(7):843-53.
REF 5 Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2. J Clin Endocrinol Metab. 2012 May;97(5):E710-8.
REF 6 Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature. 2014 Apr 24;508(7497):531-5.
REF 7 Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroidells, and impacts on MEK and TRAIL protein expression. Int J Mol Med. 2016 Aug;38(2):433-45.
REF 8 Amplified 7q21-22 gene MCM7 and its intronic miR-25 suppress COL1A2 associated genes to sustain intestinal gastric cancer features. Mol Carcinog. 2017 Jun;56(6):1590-1602.
REF 9 Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. Mol Cell Biol. 2008 Oct;28(20):6262-77.
REF 10 MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotype. Am J Respir Cell Mol Biol. 2010 Apr;42(4):506-13.
REF 11 MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes. Biochem Pharmacol. 2016 Aug 1;113:88-96.
REF 12 MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90.
REF 13 miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells. Biochem Biophys Res Commun. 2015 May 8;460(3):806-12.
REF 14 Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal. 2010 Apr 13;3(117):ra29.
REF 15 Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification). Nucleic Acids Res. 2014 Apr;42(8):e66.
REF 16 MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2012 May 18;421(4):640-5.
REF 17 p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. Mol Cancer Res. 2015 Mar;13(3):584-91.
REF 18 Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. Nucleic Acids Res. 2009 Apr;37(5):1672-81.
REF 19 MiR-25 promotes gastric cancer cells growth and motility by targeting RECK. Mol Cell Biochem. 2014 Jan;385(1-2):207-13.
REF 20 E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell. 2008 Mar;13(3):272-86.
REF 21 MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5316-21.
REF 22 MiR-25 suppresses 3T3-L1 adipogenesis by directly targeting KLF4 and C/EBP. J Cell Biochem. 2015 Nov;116(11):2658-66.
REF 23 Down-regulated desmocollin-2 promotes cell aggressiveness through redistributing adherens junctions and activating beta-catenin signalling in oesophageal squamous cell carcinoma.J Pathol. 2013 Oct;231(2):257-70.
REF 24 REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility.Oncogene. 2013 Jan 10;32(2):242-50.
REF 25 Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroidells, and impacts on MEK and TRAIL protein expression. Int J Mol Med. 2016 Aug;38(2):433-45.
REF 26 Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.Nat Cell Biol. 2013 Nov;15(11):1282-93.
REF 27 Elevated microRNA-25 inhibits cell apoptosis in lung cancer by targeting RGS3.In Vitro Cell Dev Biol Anim. 2016 Jan;52(1):62-7.
REF 28 miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells.Cancer Sci. 2017 Jan;108(1):23-31.
REF 29 TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC.PLoS One. 2012;7(9):e45133.
REF 30 miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma.Hepatology. 2012 Feb;55(2):465-75.

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