miRNA General Information
miRNA Mature ID hsa-miR-33b-5p
miRNA Stemloop AC MI0003646
miRNA Stemloop ID hsa-mir-33b
Sequence gugcauugcuguugcauugc
TTD Target(s) Regulated by This miRNA Proto-oncogene c-Src (SRC) Successful Target Target Info [1]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [2]
ATP-binding cassette transporter A1 (ABCA1) Successful Target Target Info [3]
Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target Target Info [4]
X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Target Info [5]
Proto-oncogene c-Myc (MYC) Literature-reported Target Target Info [6]
Nuclear receptor ROR-alpha (RORA) Preclinical Target Target Info [1]
Cyclic AMP-responsive element-binding protein (CREB1) Literature-reported Target Target Info [1]
Glucose-6-phosphatase (G6PC) Clinical trial Target Target Info [1]
High mobility group protein HMGI-C (HMGA2) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Regulated Protein [1]
Twist-related protein 1 Regulated Protein [7]
Zinc finger E-box-binding homeobox 1 Regulated Protein [10]
References
REF 1 MicroRNA 33 regulates glucose metabolism. Mol Cell Biol. 2013 Aug;33(15):2891-902.
REF 2 Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer. 2008 Sep 21;8:266.
REF 3 MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 2010 Jun 18;328(5985):1566-9.
REF 4 Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells.Blood.2012 Nov 8;120(19):3958-67.
REF 5 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. Genes Dev. 2013 Jul 15;27(14):1624-32.
REF 6 A statin-regulated microRNA represses human c-Myc expression and function. EMBO Mol Med. 2012 Sep;4(9):896-909.
REF 7 Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b. Oncotarget. 2015;6(12):9834-53.
REF 8 MicroRNA 33 regulates glucose metabolism. Mol Cell Biol. 2013 Aug;33(15):2891-902.
REF 9 Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b. Oncotarget. 2015;6(12):9834-53.
REF 10 MicroRNA-33b inhibits lung adenocarcinoma cell growth, invasion, and epithelial-mesenchymal transition by suppressing Wnt/-catenin/ZEB1 signaling.Int J Oncol. 2015 Dec;47(6):2141-52.

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