miRNA General Information
miRNA Mature ID hsa-miR-34b-5p
miRNA Stemloop AC MI0000742
miRNA Stemloop ID hsa-mir-34b
Sequence uaggcagugucauuagcugauug
TTD Target(s) Regulated by This miRNA Cyclin-dependent kinase 4 (CDK4) Successful Target Target Info [1]
Cyclin-dependent kinase 6 (CDK6) Successful Target Target Info [1]
Proto-oncogene c-Met (MET) Successful Target Target Info [1]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [2]
Programmed cell death 1 ligand 1 (PD-L1) Successful Target Target Info [3]
Vascular endothelial growth factor A (VEGFA) Successful Target Target Info [4]
Beta-catenin (CTNNB1) Successful Target Target Info [5]
TGF-beta receptor type II (TGFBR2) Clinical trial Target Target Info [6]
Proto-oncogene c-Myc (MYC) Literature-reported Target Target Info [7]
Hepatocyte nuclear factor 4-alpha (HNF4A) Literature-reported Target Target Info [8]
Cyclic AMP-responsive element-binding protein (CREB1) Literature-reported Target Target Info [9]
N-myc proto-oncogene protein (MYCN) Literature-reported Target Target Info [10]
G1/S-specific cyclin-E2 (CCNE2) Literature-reported Target Target Info [1]
Protein(s) Regulated by This miRNA Axin-2 Regulated Protein [5]
References
REF 1 The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010 Feb;17(2):193-9.
REF 2 Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer. 2008 Sep 21;8:266.
REF 3 Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c. Br J Cancer. 2014 Apr 15;110(8):2072-80.
REF 4 The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 2008 Mar 5;3(3):e1719.
REF 5 MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle. 2012 Apr 1;11(7):1273-81.
REF 6 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.Genes Dev. 2011 Oct 15;25(20):2173-86.
REF 7 Prediction and preliminary validation of oncogene regulation by miRNAs. BMC Mol Biol. 2007 Sep 18;8:79.
REF 8 In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4 expression. Drug Metab Dispos. 2012 Apr;40(4):726-33.
REF 9 miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Res. 2009 Mar 15;69(6):2471-8.
REF 10 A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells. Oncotarget. 2016 Nov 29;7(48):79372-79387.
REF 11 MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle. 2012 Apr 1;11(7):1273-81.

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