Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T53381
|
||||
Former ID |
TTDS00030
|
||||
Target Name |
Alpha-1D adrenergic receptor
|
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Gene Name |
ADRA1D
|
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Synonyms |
Alpha 1D-adrenoceptor; Alpha 1D-adrenoreceptor; Alpha adrenergic receptor 1a; Alpha-1A adrenergic receptor; ADRA1D
|
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Target Type |
Successful
|
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Disease | Benign prostatic hyperplasia [ICD9: 600; ICD10: N40] | ||||
Congestive heart failure [ICD9: 428; ICD10: I50] | |||||
Diabetes [ICD9: 253.5, 588.1; ICD10: E23.2, N25.1] | |||||
Erectile dysfunction [ICD9: 302.72, 607.84; ICD10: F52.2, N48.4] | |||||
Fecal incontinence [ICD10: R15] | |||||
Glaucoma [ICD9: 365; ICD10: H40-H42] | |||||
Hypertension [ICD9: 401; ICD10: I10-I16] | |||||
Heart arrhythmia [ICD10: I47-I49] | |||||
Pediatric cancer [ICD9: 140-229; ICD10: C00-C96] | |||||
Prostate disease [ICD10: N42.9] | |||||
Peripheral vascular disease [ICD9: 443.9; ICD10: I73.9] | |||||
Prostate hyperplasia [ICD10: N40] | |||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Urinary incontinence [ICD9: 788.3; ICD10: N39.3, N39.4, R32] | |||||
Unspecified [ICD code not available] | |||||
Function |
This alpha-adrenergic receptor mediatesits effect through the influx of extracellular calcium.
|
||||
BioChemical Class |
GPCR rhodopsin
|
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Target Validation |
T53381
|
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UniProt ID | |||||
Sequence |
MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE AVSLGVPHEVAEGATCQAYELADYSNLRETDI |
||||
Drugs and Mode of Action | |||||
Drug(s) | Alfuzosin | Drug Info | Approved | Benign prostatic hyperplasia | [536610], [542116] |
Armodafinil | Drug Info | Approved | Pediatric cancer | [551871] | |
Bunazosin | Drug Info | Approved | Glaucoma | [551871] | |
Doxazosin | Drug Info | Approved | Hypertension | [536610], [542180] | |
Moxisylyte | Drug Info | Approved | Erectile dysfunction | [551871] | |
Phenylephrine hydrochloride gel | Drug Info | Approved | Fecal incontinence | [547809] | |
Terazosin | Drug Info | Approved | Benign prostatic hyperplasia | [538289], [542324] | |
Trimazosin | Drug Info | Approved | Congestive heart failure | [551871] | |
MEDETOMIDINE | Drug Info | Phase 2 | Pain | [529347] | |
DL-017 | Drug Info | Phase 1 | Hypertension | [526190] | |
INDORAMIN | Drug Info | Withdrawn from market | Hypertension | [468125], [551871] | |
Sunepitron | Drug Info | Discontinued in Phase 3 | Discovery agent | [545699] | |
TIOSPIRONE | Drug Info | Discontinued in Phase 3 | Discovery agent | [538617], [544679] | |
Dabuzalgron | Drug Info | Discontinued in Phase 2 | Urinary incontinence | [540407], [547205] | |
Deriglidole | Drug Info | Discontinued in Phase 2 | Diabetes | [544511] | |
FCE-22716 | Drug Info | Discontinued in Phase 2 | Hypertension | [533340] | |
FIDUXOSIN HYDROCHLORIDE | Drug Info | Discontinued in Phase 2 | Prostate disease | [547070] | |
GYKI-16084 | Drug Info | Discontinued in Phase 2 | Prostate disease | [546866] | |
JTH-601 | Drug Info | Discontinued in Phase 2 | Prostate disease | [546856] | |
MAZAPERTINE | Drug Info | Discontinued in Phase 2 | Discovery agent | [545274] | |
NS-49 | Drug Info | Discontinued in Phase 2 | Urinary incontinence | [468041], [545984] | |
OPC-28326 | Drug Info | Discontinued in Phase 2 | Peripheral vascular disease | [546957] | |
REC-15-2739 | Drug Info | Discontinued in Phase 2 | Prostate disease | [545508] | |
SL-25.1039 | Drug Info | Discontinued in Phase 2 | Urinary incontinence | [547287] | |
SL-89.0591 | Drug Info | Discontinued in Phase 2 | Prostate disease | [545536] | |
SOU-001 | Drug Info | Discontinued in Phase 2 | Urinary incontinence | [547251] | |
SUN-9221 | Drug Info | Discontinued in Phase 1 | Hypertension | [546178] | |
ABANOQUIL | Drug Info | Terminated | Discovery agent | [544556] | |
AGN-193080 | Drug Info | Terminated | Discovery agent | [546437] | |
BMY-7378 | Drug Info | Terminated | Discovery agent | [543289], [544847] | |
CR-2991 | Drug Info | Terminated | Hypertension | [547727] | |
NIGULDIPINE | Drug Info | Terminated | Discovery agent | [468083], [545183] | |
Siramesine | Drug Info | Terminated | Discovery agent | [545008] | |
SK&F-104078 | Drug Info | Terminated | Discovery agent | [544626] | |
SK&F-104856 | Drug Info | Terminated | Discovery agent | [544924] | |
SL-91.0893 | Drug Info | Terminated | Prostate hyperplasia | [546240] | |
SNAP-5089 | Drug Info | Terminated | Heart arrhythmia | [468115], [546179] | |
WB-4101 | Drug Info | Terminated | Discovery agent | [468117], [545656] | |
Sunepitron | Drug Info | Investigative | Unspecified | [528210] | |
Inhibitor | (+/-)-nantenine | Drug Info | [530558] | ||
(2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine | Drug Info | [534315] | |||
(2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine | Drug Info | [534315] | |||
1',2',3',6'-Tetrahydro-[2,4']bipyridinyl | Drug Info | [533509] | |||
1-(2-Chloro-phenyl)-piperazine | Drug Info | [528039] | |||
1-(2-Methoxy-phenyl)-piperazine | Drug Info | [528039] | |||
1-(3-Fluoro-pyridin-2-yl)-4-methyl-piperazine | Drug Info | [533509] | |||
1-(pyridin-2-yl)piperazine | Drug Info | [533509] | |||
2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline | Drug Info | [526618] | |||
4-((E)-1-Naphthalen-1-yl-propenyl)-1H-imidazole | Drug Info | [534160] | |||
4-((Z)-1-Naphthalen-1-yl-propenyl)-1H-imidazole | Drug Info | [534160] | |||
4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | Drug Info | [533805] | |||
4-(1-Naphthalen-1-yl-propyl)-1H-imidazole | Drug Info | [534160] | |||
4-(1-Naphthalen-1-yl-vinyl)-1H-imidazole | Drug Info | [534160] | |||
4-(2,3-Dihydro-1H-phenalen-1-yl)-1H-imidazole | Drug Info | [534160] | |||
4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline | Drug Info | [526618] | |||
4-(3-Hydroxy-piperidin-3-yl)-benzene-1,2-diol | Drug Info | [526729] | |||
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one | Drug Info | [531079] | |||
4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one | Drug Info | [528062] | |||
4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one | Drug Info | [528062] | |||
4-(4-chlorobenzyl)phthalazin-1(2H)-one | Drug Info | [528062] | |||
4-(4-Isopropyl-morpholin-2-yl)-benzene-1,2-diol | Drug Info | [526729] | |||
4-(4-Methyl-indan-1-yl)-1H-imidazole | Drug Info | [534467] | |||
4-Benzo[b]thiophen-4-yl-1H-imidazole | Drug Info | [525720] | |||
4-benzyl-2-methylphthalazin-1(2H)-one | Drug Info | [528062] | |||
4-Morpholin-2-yl-benzene-1,2-diol | Drug Info | [526729] | |||
5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine | Drug Info | [526778] | |||
6-hydroxy-3-(3',5'-dihydroxyphenyl)coumarin | Drug Info | [527848] | |||
8-Piperazin-1-yl-imidazo[1,2-a]pyrazine | Drug Info | [526778] | |||
ABANOQUIL | Drug Info | [533682] | |||
AGN-192172 | Drug Info | [551280] | |||
AGN-193080 | Drug Info | [551280] | |||
BMY-7378 | Drug Info | [527512] | |||
CORYNANTHEINE | Drug Info | [533638] | |||
FLUANISONE | Drug Info | [533378] | |||
Imidazolidin-2-ylidene-o-tolyl-amine | Drug Info | [551280] | |||
Imidazolidin-2-ylidene-quinoxalin-6-yl-amine | Drug Info | [551280] | |||
INDORAMIN | Drug Info | [533682] | |||
ISOCLOZAPINE | Drug Info | [534532] | |||
LEVONORDEFRIN | Drug Info | [534160] | |||
MAZAPERTINE | Drug Info | [533800] | |||
MEDETOMIDINE | Drug Info | [533805] | |||
N-(5-Bromo-quinoxalin-6-yl)-guanidine | Drug Info | [551280] | |||
NIGULDIPINE | Drug Info | [533638] | |||
OCTOCLOTHEPIN | Drug Info | [531171] | |||
RWJ-38063 | Drug Info | [525785] | |||
RWJ-68157 | Drug Info | [525785] | |||
RWJ-69736 | Drug Info | [525785] | |||
RX-821002 | Drug Info | [533375] | |||
Siramesine | Drug Info | [533739] | |||
SK&F-104078 | Drug Info | [533638] | |||
SK&F-104856 | Drug Info | [533638] | |||
SK&F-105854 | Drug Info | [533638] | |||
SK&F-106686 | Drug Info | [533638] | |||
SK&F-86466 | Drug Info | [533638] | |||
SNAP-5089 | Drug Info | [533638] | |||
SNAP-8719 | Drug Info | [527512] | |||
Sunepitron | Drug Info | [528210] | |||
TIOSPIRONE | Drug Info | [534093] | |||
UH-301 | Drug Info | [534363] | |||
WB-4101 | Drug Info | [533682] | |||
Agonist | 4-Methoxyamphetamine | Drug Info | [551380] | ||
Armodafinil | Drug Info | [544068], [550911] | |||
Dabuzalgron | Drug Info | [540407] | |||
SL-25.1039 | Drug Info | [550220] | |||
Antagonist | Alfuzosin | Drug Info | [535396] | ||
CR-2991 | Drug Info | [550128] | |||
Doxazosin | Drug Info | [536929] | |||
FIDUXOSIN HYDROCHLORIDE | Drug Info | [526250] | |||
GYKI-16084 | Drug Info | [528199] | |||
JTH-601 | Drug Info | [525752] | |||
OPC-28326 | Drug Info | [525613] | |||
Terazosin | Drug Info | [535079], [535647] | |||
Modulator | Bunazosin | Drug Info | [527544], [551871] | ||
Deriglidole | Drug Info | [534576] | |||
DL-017 | Drug Info | [526190] | |||
FCE-22716 | Drug Info | [533340] | |||
Moxisylyte | Drug Info | [534246], [551871] | |||
NS-49 | Drug Info | [525556] | |||
Phenylephrine hydrochloride gel | Drug Info | [527269] | |||
REC-15-2739 | Drug Info | [534138] | |||
SL-89.0591 | Drug Info | [525538] | |||
SL-91.0893 | Drug Info | [551953] | |||
SOU-001 | Drug Info | [527154] | |||
SUN-9221 | Drug Info | [525435] | |||
Trimazosin | Drug Info | [533525], [551871] | |||
Pathways | |||||
KEGG Pathway | Calcium signaling pathway | ||||
cGMP-PKG signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Adrenergic signaling in cardiomyocytes | |||||
Vascular smooth muscle contraction | |||||
Salivary secretion | |||||
NetPath Pathway | IL2 Signaling Pathway | ||||
Reactome | Adrenoceptors | ||||
G alpha (q) signalling events | |||||
G alpha (12/13) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
Calcium Regulation in the Cardiac Cell | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References | |||||
Ref 468041 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 481). | ||||
Ref 468083 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 487). | ||||
Ref 468115 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 498). | ||||
Ref 468117 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 499). | ||||
Ref 468125 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 501). | ||||
Ref 526190 | Antihypertensive action and blockade of alpha1-adrenoceptors by DL-017, a quinazoline derivative. J Cardiovasc Pharmacol. 2001 Dec;38(6):893-9. | ||||
Ref 528210 | J Med Chem. 2006 Jun 1;49(11):3116-35.An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. | ||||
Ref 529347 | Sedative and cardiopulmonary effects of medetomidine hydrochloride and xylazine hydrochloride and their reversal with atipamezole hydrochloride in calves. Am J Vet Res. 2008 Mar;69(3):319-29. | ||||
Ref 533340 | Mechanism of the antihypertensive effect of FCE 22716, a new ergoline derivative, in the spontaneously hypertensive rat. Pharmacology. 1989;38(2):78-92. | ||||
Ref 536610 | Alpha blockers for the treatment of benign prostatic hyperplasia. Rev Urol. 2007 Fall;9(4):181-90. | ||||
Ref 538289 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074823. | ||||
Ref 538617 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 101). | ||||
Ref 540407 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3469). | ||||
Ref 542116 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7109). | ||||
Ref 542180 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7170). | ||||
Ref 542324 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7302). | ||||
Ref 543289 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 9). | ||||
Ref 544511 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000010) | ||||
Ref 544556 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000128) | ||||
Ref 544626 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000354) | ||||
Ref 544679 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000562) | ||||
Ref 544847 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001317) | ||||
Ref 544924 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001560) | ||||
Ref 545008 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001859) | ||||
Ref 545183 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002398) | ||||
Ref 545274 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002662) | ||||
Ref 545508 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003537) | ||||
Ref 545536 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003628) | ||||
Ref 545656 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004048) | ||||
Ref 545699 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004255) | ||||
Ref 545984 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005693) | ||||
Ref 546178 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006767) | ||||
Ref 546179 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006771) | ||||
Ref 546240 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007056) | ||||
Ref 546437 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008130) | ||||
Ref 546856 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010685) | ||||
Ref 546866 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010746) | ||||
Ref 546957 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011559) | ||||
Ref 547070 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012814) | ||||
Ref 547205 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013967) | ||||
Ref 547251 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014478) | ||||
Ref 547287 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014859) | ||||
Ref 547727 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018844) | ||||
Ref 525435 | Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo). 1999 Feb;47(2):246-56. | ||||
Ref 525538 | Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity. Eur J Pharmacol. 1999 May 28;373(1):51-62. | ||||
Ref 525556 | Pharmacokinetics of NS-49, a phenethylamine class alpha 1A-adrenoceptor agonist. 3rd communication: metabolism in rats, rabbits, dogs and monkeys, and effects on hepatic drug-metabolizing enzyme activities in rats after repeated administration. Arzneimittelforschung. 1999 Jul;49(7):612-7. | ||||
Ref 525613 | Mechanisms of action of OPC-28326, a selective hindlimb vasodilator. J Pharmacol Exp Ther. 1999 Nov;291(2):604-11. | ||||
Ref 525720 | J Med Chem. 2000 Mar 9;43(5):765-8.alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor. | ||||
Ref 525752 | Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs. Eur J Pharmacol. 2000 Apr 7;394(1):123-30. | ||||
Ref 525785 | Bioorg Med Chem Lett. 2000 May 15;10(10):1093-6.Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists. | ||||
Ref 526190 | Antihypertensive action and blockade of alpha1-adrenoceptors by DL-017, a quinazoline derivative. J Cardiovasc Pharmacol. 2001 Dec;38(6):893-9. | ||||
Ref 526250 | Effect of fiduxosin, an antagonist selective for alpha(1A)- and alpha(1D)-adrenoceptors, on intraurethral and arterial pressure responses in conscious dogs. J Pharmacol Exp Ther. 2002 Feb;300(2):487-94. | ||||
Ref 526618 | Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62.4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists. | ||||
Ref 526729 | J Med Chem. 1992 Mar 20;35(6):1009-18.Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors. | ||||
Ref 526778 | J Med Chem. 1992 Oct 16;35(21):3845-57.Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. | ||||
Ref 527154 | Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004 Aug;3(8):673-83. | ||||
Ref 527269 | Effects of topically instilled bunazosin, an alpha1-adrenoceptor antagonist, on constrictions induced by phenylephrine and ET-1 in rabbit retinal arteries. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4041-8. | ||||
Ref 527512 | J Med Chem. 2005 Apr 21;48(8):3076-9.Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists. | ||||
Ref 527544 | Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage. Cardiovasc Drug Rev. 2005 Spring;23(1):43-56. | ||||
Ref 527848 | Bioorg Med Chem Lett. 2006 Jan 15;16(2):257-61. Epub 2005 Nov 3.Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids. | ||||
Ref 528039 | J Med Chem. 1991 Jun;34(6):1850-4.Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. | ||||
Ref 528062 | Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. Epub 2006 Mar 2.Vasorelaxant activity of phthalazinones and related compounds. | ||||
Ref 528199 | A novel approach to the treatment of benign prostatic hyperplasia. BJU Int. 2006 Jun;97(6):1252-5. | ||||
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