Drug General Information
Drug ID	D00YGP
Former ID	DNC012913
Drug Name	6-hydroxy-3-(3',5'-dihydroxyphenyl)coumarin
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527848]
Structure		Download 2D MOL 3D MOL
Formula	C15H10O5
Canonical SMILES	C1=CC2=C(C=C1O)C=C(C(=O)O2)C3=CC(=CC(=C3)O)O
InChI	1S/C15H10O5/c16-10-1-2-14-9(5-10)6-13(15(19)20-14)8-3-11(17)7-12(18)4-8/h1-7,16-18H
InChIKey	DKFCOAXLNVHDTF-UHFFFAOYSA-N
PubChem Compound ID	11536337
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[527848]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
NetPath Pathway	IL2 Signaling Pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 527848	Bioorg Med Chem Lett. 2006 Jan 15;16(2):257-61. Epub 2005 Nov 3.Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids.
Ref 527848	Bioorg Med Chem Lett. 2006 Jan 15;16(2):257-61. Epub 2005 Nov 3.Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids.

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