Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U3HP
|
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| Former ID |
DNC003770
|
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| Drug Name |
ABANOQUIL
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H29N3O7S
|
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| Canonical SMILES |
COC1=C(C=C2CN(CCC2=C1)C3=NC4=CC(=C(C=C4C(=C3)N)OC)OC)OC
|
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| InChI |
1S/C22H25N3O4/c1-26-18-7-13-5-6-25(12-14(13)8-19(18)27-2)22-10-16(23)15-9-20(28-3)21(29-4)11-17(15)24-22/h7-11H,5-6,12H2,1-4H3,(H2,23,24)
|
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| InChIKey |
ANZIISNSHPKVRV-UHFFFAOYSA-N
|
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| CAS Number |
CAS 90402-40-7
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Alpha-1A adrenergic receptor | Target Info | Inhibitor | [2] | |
| Alpha-1D adrenergic receptor | Target Info | Inhibitor | [2] | ||
| Alpha-1B adrenergic receptor | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| AMPK signaling pathway | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Salivary secretionhsa04020:Calcium signaling pathway | |||||
| Salivary secretion | |||||
| NetPath Pathway | IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway | ||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway | ||||
| Pathway Interaction Database | LPA receptor mediated events | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors | |||||
| G alpha (12/13) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Endothelin Pathways | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| AMPK SignalingWP58:Monoamine GPCRs | |||||
| GPCRs, OtherWP58:Monoamine GPCRs | |||||
| Vitamin D Receptor Pathway | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000128) | ||||
| REF 2 | J Med Chem. 1995 Sep 1;38(18):3415-44.Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. | ||||
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