Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0E5CI
|
||||
| Former ID |
DNC011435
|
||||
| Drug Name |
8-Piperazin-1-yl-imidazo[1,2-a]pyrazine
|
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| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H13N5
|
||||
| Canonical SMILES |
C1CN(CCN1)C2=NC=CN3C2=NC=C3
|
||||
| InChI |
1S/C10H13N5/c1-5-14(6-2-11-1)9-10-13-4-8-15(10)7-3-12-9/h3-4,7-8,11H,1-2,5-6H2
|
||||
| InChIKey |
NSHLOJVJEGEMSF-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Alpha-1D adrenergic receptor | Target Info | Inhibitor | [1] | |
| Alpha-1A adrenergic receptor | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Salivary secretionhsa04020:Calcium signaling pathway | |||||
| AMPK signaling pathway | |||||
| Salivary secretion | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors | |||||
| G alpha (12/13) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP58:Monoamine GPCRs | |||||
| Endothelin Pathways | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | J Med Chem. 1992 Oct 16;35(21):3845-57.Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. | ||||
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