Drug General Information
Drug ID
D0J5RN
Former ID
DNCL003087
Drug Name
Armodafinil
Drug Type
Small molecular drug
Indication Pediatric cancer [ICD9: 140-229; ICD10:C00-C96] Approved [551871]
Company
Cephalon
Structure
Download
2D MOL

3D MOL

Formula
C15H15NO2S
Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
InChI
1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1
InChIKey
YFGHCGITMMYXAQ-LJQANCHMSA-N
CAS Number
CAS 112111-43-0
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
N06BA07
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Agonist [544068], [550911]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 544068Mechanisms of modafinil: A review of current research. Neuropsychiatr Dis Treat. 2007 June; 3(3): 349-364.
Ref 550911US patent application no. 2014,0349,964, Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder.

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