Drug Information

Drug General Information
Drug ID
D09MWJ
Former ID
DAP000370
Drug Name
Alfuzosin
Synonyms
Alfusosine; Alfuzosina; Alfuzosine; Alfuzosinum; Alphuzosine; Alfuzosina [Spanish]; Alfuzosine [French]; Alfuzosinum [Latin]; SL 77499; Alfuzosin (INN); Alfuzosin [INN:BAN]; SL 77-499; Uroxatral (TN); Xatral (TN); N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide; N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide; N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide
Drug Type
Small molecular drug
Indication Benign prostatic hyperplasia [ICD9: 600; ICD10:N40] Approved [536610], [542116]
Therapeutic Class
Antihypertensive Agents
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C19H27N5O4
InChI
InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)
InChIKey
WNMJYKCGWZFFKR-UHFFFAOYSA-N
CAS Number
CAS 81403-80-7
PubChem Compound ID
2092
PubChem Substance ID
7348779, 7978547, 8151421, 11371965, 11374754, 11466350, 11467470, 11484165, 11485980, 11488321, 11490878, 11493022, 14805133, 26612860, 26680540, 26719847, 26749009, 26749010, 29221272, 46386655, 46508512, 47509539, 47656603, 47730752, 47879632, 48029201, 48328565, 49681674, 49699344, 49971151, 50107503, 50107504, 50315525, 51091463, 56464294, 57321133, 81092780, 85209969, 85788468, 85789670, 90341616, 92124875, 92308116, 92308400, 103194715, 103941451, 104299580, 117887447, 124637420, 124658863
ChEBI ID
ChEBI:51141
SuperDrug ATC ID
G04CA01
SuperDrug CAS ID
cas=081403807
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Antagonist [535396]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536610Alpha blockers for the treatment of benign prostatic hyperplasia. Rev Urol. 2007 Fall;9(4):181-90.
Ref 542116(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7109).
Ref 535396Alfuzosin: a review of the therapeutic use of the prolonged-release formulation given once daily in the management of benign prostatic hyperplasia. Drugs. 2002;62(4):633-53.

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