Drug Information

Drug General Information
Drug ID
D0ZB3X
Former ID
DNC012444
Drug Name
RX-821002
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540723]
Structure
Download
2D MOL
Formula
C12H14N2O3
InChI
InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14)
InChIKey
HQGWKNGAKBPTBX-UHFFFAOYSA-N
PubChem Compound ID
108094
PubChem Substance ID
840954, 842020, 7536812, 7980550, 10234596, 11364712, 11367274, 11369836, 11378000, 11495622, 14749421, 44436992, 47572603, 48168573, 48393132, 49979496, 50104814, 57338437, 76822660, 85209706, 85788141, 90341601, 103169829, 103930440, 104380489, 124750201, 124881351, 128097672, 134224937, 134349649, 135066174, 135650954, 135651200, 136905176, 140884806, 141391967, 152253110, 162169298, 179236103, 228600997
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Inhibitor [533375]
Alpha-1A adrenergic receptor Target Info Inhibitor [533375]
Alpha-1B adrenergic receptor Target Info Inhibitor [533375]
Alpha-2A adrenergic receptor Target Info Inhibitor [533375]
Alpha-2B adrenergic receptor Target Info Inhibitor [533375]
Alpha-1D adrenergic receptor Target Info Inhibitor [533375]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
Salivary secretionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
GPCRs, Other
References
Ref 540723(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 526).
Ref 533375J Med Chem. 1986 Oct;29(10):2000-3.Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists.

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