Drug General Information
Drug ID	D07QCC
Former ID	DNC003925
Drug Name	SK&F-106686
Synonyms	SK-106686
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533638]
Structure		Download 2D MOL 3D MOL
Formula	C14H16ClNS
Canonical SMILES	CCC1=C2CN(CCC3=C(C=CC(=C32)S1)Cl)C
InChI	1S/C14H16ClNS/c1-3-12-10-8-16(2)7-6-9-11(15)4-5-13(17-12)14(9)10/h4-5H,3,6-8H2,1-2H3
InChIKey	BAAUEDJUTZLMAN-UHFFFAOYSA-N
PubChem Compound ID	10946567
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[533638]
	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[533638]
	Alpha-1B adrenergic receptor	Target Info	Inhibitor	[533638]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04020:Calcium signaling pathway
	AMPK signaling pathway
	Salivary secretion
NetPath Pathway	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database	LPA receptor mediated events
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Endothelin Pathways
	AMPK SignalingWP58:Monoamine GPCRs
	Vitamin D Receptor Pathway
	AMPK Signaling
References
Ref 533638	J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Ref 533638	J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

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