Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D03ITI
|
||||
Former ID |
DNC006590
|
||||
Drug Name |
Sunepitron
|
||||
Synonyms |
Sunepitron hydrochloride; SUNEPITRON HYDROCHLORIDE; (7S,9aS)-7-(2,5-Dioxopyrrolidin-1-ylmethyl)-2-(2-pyrimidinyl)octahydro-1H-pyrido[1,2-a]pyrazine hydrochloride; (7S,9aS)-1-[2-(2-Pyrimidinyl)perhydropyrido[1,2-a]pyrazin-7-ylmethyl]pyrrolidine-2,5-dione hydrochloride; Sunepitron hydrochloride < Prop INNM; USAN >; CP-93393 (free base); CP-93393-1; 131831-03-3
|
||||
Drug Type |
Small molecular drug
|
||||
Structure |
Download2D MOL |
||||
Formula |
C17H24ClN5O2
|
||||
Canonical SMILES |
C1CC2CN(CCN2CC1CN3C(=O)CCC3=O)C4=NC=CC=N4
|
||||
InChI |
1S/C17H23N5O2/c23-15-4-5-16(24)22(15)11-13-2-3-14-12-21(9-8-20(14)10-13)17-18-6-1-7-19-17/h1,6-7,13-14H,2-5,8-12H2
|
||||
InChIKey |
UXWBIYCPUVWKHP-UHFFFAOYSA-N
|
||||
CAS Number |
CAS 148408-65-5
|
||||
PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Alpha-1B adrenergic receptor | Target Info | Inhibitor | [528210] | |
5-hydroxytryptamine 1A receptor | Target Info | Inhibitor | [528210] | ||
Alpha-1A adrenergic receptor | Target Info | Inhibitor | [528210] | ||
Alpha-1D adrenergic receptor | Target Info | Inhibitor | [528210] | ||
KEGG Pathway | Calcium signaling pathway | ||||
cGMP-PKG signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Adrenergic signaling in cardiomyocytes | |||||
Vascular smooth muscle contraction | |||||
Salivary secretionhsa04024:cAMP signaling pathway | |||||
Serotonergic synapsehsa04020:Calcium signaling pathway | |||||
AMPK signaling pathway | |||||
Salivary secretionhsa04020:Calcium signaling pathway | |||||
Salivary secretion | |||||
NetPath Pathway | IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway | ||||
Pathway Interaction Database | LPA receptor mediated events | ||||
WikiPathways | Monoamine GPCRs | ||||
Calcium Regulation in the Cardiac Cell | |||||
GPCRs, Class A Rhodopsin-like | |||||
Vitamin D Receptor Pathway | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
AMPK SignalingWP722:Serotonin HTR1 Group and FOS Pathway | |||||
SIDS Susceptibility Pathways | |||||
GPCR downstream signalingWP58:Monoamine GPCRs | |||||
Endothelin Pathways | |||||
AMPK SignalingWP58:Monoamine GPCRs | |||||
GPCRs, Other | |||||
References | |||||
Ref 528210 | J Med Chem. 2006 Jun 1;49(11):3116-35.An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. | ||||
Ref 545699 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004255) |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.