Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S0AF
|
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| Former ID |
DIB001233
|
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| Drug Name |
Bunazosin
|
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| Synonyms |
Andante; E 015; DE-070; Detantol-R; E-1015; E-643
|
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| Drug Type |
Small molecular drug
|
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| Indication | Glaucoma [ICD9: 365; ICD10:H40-H42] | Approved | [1] | ||
| Company |
Eisai Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H28ClN5O3
|
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| Canonical SMILES |
c1(nc(c2c(n1)cc(c(c2)OC)OC)N)N1CCN(C(=O)CCC)CCC1
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Alpha-1D adrenergic receptor | Target Info | Modulator | [2], [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Salivary secretion | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 2 | Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage. Cardiovasc Drug Rev. 2005 Spring;23(1):43-56. | ||||
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