Drug Information
Drug General Information | |||||
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Drug ID |
D0U0QI
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Former ID |
DIB006006
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Drug Name |
GYKI-16084
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Synonyms |
Uroflux; IDR-16084; (+)-(R)-2-[3-(Benzo-1,4-dioxan-2-ylmethylamino)propyl]pyridazin-3(2H)-one hydrochloride
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Drug Type |
Small molecular drug
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Indication | Prostate disease [ICD10:N42.9] | Discontinued in Phase 2 | [546866] | ||
Structure |
Download2D MOL |
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Formula |
C16H19N3O3
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Canonical SMILES |
C1C(OC2=CC=CC=C2O1)CNCCCN3C(=O)C=CC=N3
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InChI |
1S/C16H19N3O3/c20-16-7-3-9-18-19(16)10-4-8-17-11-13-12-21-14-5-1-2-6-15(14)22-13/h1-3,5-7,9,13,17H,4,8,10-12H2/t13-/m1/s1
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InChIKey |
FJNRJBQUOQLUNQ-CYBMUJFWSA-N
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CAS Number |
CAS 185739-21-3
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Alpha-2C adrenergic receptor | Target Info | Antagonist | [528199] | |
Alpha-1D adrenergic receptor | Target Info | Antagonist | [528199] | ||
NetPath Pathway | IL2 Signaling Pathway | ||||
Reactome | Adrenoceptors | ||||
Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
Adrenaline,noradrenaline inhibits insulin secretion | |||||
G alpha (i) signalling events | |||||
G alpha (z) signalling events | |||||
Surfactant metabolismR-HSA-390696:Adrenoceptors | |||||
G alpha (q) signalling events | |||||
G alpha (12/13) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Platelet Aggregation (Plug Formation) | |||||
Integration of energy metabolism | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP58:Monoamine GPCRs | |||||
Calcium Regulation in the Cardiac Cell | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References |
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