Drug Information

Drug General Information
Drug ID
D02TQC
Former ID
DNC003849
Drug Name
N-(5-Bromo-quinoxalin-6-yl)-guanidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551280]
Structure
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2D MOL

3D MOL
Formula
C9H8BrN5
Canonical SMILES
C1=CC2=NC=CN=C2C(=C1N=C(N)N)Br
InChI
1S/C9H8BrN5/c10-7-5(15-9(11)12)1-2-6-8(7)14-4-3-13-6/h1-4H,(H4,11,12,15)
InChIKey
WBGSURPVIDDDHF-UHFFFAOYSA-N
PubChem Compound ID
14928441
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [551280]
Alpha-1D adrenergic receptor Target Info Inhibitor [551280]
Alpha-1B adrenergic receptor Target Info Inhibitor [551280]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
GPCRs, OtherWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
AMPK Signaling
References
Ref 551280Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995).
Ref 551280Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995).

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