| Drug General Information |
| Drug ID |
D08OJU
|
| Former ID |
DIB009432
|
| Drug Name |
SOU-001
|
| Synonyms |
AA-10020; DRP-001
|
| Indication |
Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32]
|
Discontinued in Phase 2 |
[1]
|
|---|
| Company |
Arachnova Therapeutics Ltd
|
| Target and Pathway |
| Target(s) |
Alpha-1B adrenergic receptor |
Target Info |
Modulator |
[2]
|
|---|
| Alpha-1A adrenergic receptor |
Target Info |
Modulator |
[2]
|
| Alpha-1D adrenergic receptor |
Target Info |
Modulator |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Adrenergic signaling in cardiomyocytes
|
|
Vascular smooth muscle contraction
|
|
Salivary secretionhsa04020:Calcium signaling pathway
|
|
AMPK signaling pathway
|
|
Salivary secretion
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
|
Pathway Interaction Database
|
LPA receptor mediated events
|
|
Reactome
|
Adrenoceptors
|
|
G alpha (q) signalling events
|
|
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
|
|
G alpha (12/13) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
GPCRs, Class A Rhodopsin-like
|
|
Vitamin D Receptor Pathway
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
AMPK SignalingWP58:Monoamine GPCRs
|
|
Endothelin Pathways
|
|
GPCRs, Other
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014478) |
|---|
| REF 2 | Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004 Aug;3(8):673-83. |
|---|
