Drug Information

Drug General Information
Drug ID
D0BC6Q
Former ID
DNC003842
Drug Name
AGN-193080
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546437]
Structure
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2D MOL

3D MOL
Formula
C12H16N4O
Canonical SMILES
CC1=C(C=CC2=C1NCCO2)NC3=NCCN3
InChI
1S/C12H16N4O/c1-8-9(16-12-14-4-5-15-12)2-3-10-11(8)13-6-7-17-10/h2-3,13H,4-7H2,1H3,(H2,14,15,16)
InChIKey
OSJZLDGTMVBIRV-UHFFFAOYSA-N
PubChem Compound ID
9837551
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Inhibitor [551280]
Alpha-1D adrenergic receptor Target Info Inhibitor [551280]
Alpha-1A adrenergic receptor Target Info Inhibitor [551280]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
GPCRs, OtherWP58:Monoamine GPCRs
Endothelin Pathways
AMPK Signaling
References
Ref 546437Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008130)
Ref 551280Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995).

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