| Drug General Information |
| Drug ID |
D01RCS
|
| Former ID |
DNC011927
|
| Drug Name |
TIOSPIRONE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Discontinued in Phase 3 |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C24H32N4O2S
|
| InChI |
InChI=1S/C24H32N4O2S/c29-21-17-24(9-3-4-10-24)18-22(30)28(21)12-6-5-11-26-13-15-27(16-14-26)23-19-7-1-2-8-20(19)31-25-23/h1-2,7-8H,3-6,9-18H2
|
| InChIKey |
ZFZPJDFBJFHYIV-UHFFFAOYSA-N
|
| CAS Number |
CAS 87691-91-6
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7980790, 8184326, 14759349, 43113700, 47359855, 47880054, 48179678, 48404436, 50065345, 57313784, 79503122, 85209441, 103211025, 103920962, 104308411, 129897246, 134349132, 135049552, 135651264, 137128378, 140448081, 179151362, 198968527, 224853459, 226457927, 241151827, 252450938
|
| Target and Pathway |
| Target(s) |
Alpha-1B adrenergic receptor |
Target Info |
Inhibitor |
[3]
|
|---|
| Alpha-1D adrenergic receptor |
Target Info |
Inhibitor |
[3]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[4]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[3]
|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[3]
|
| Alpha-1A adrenergic receptor |
Target Info |
Inhibitor |
[3]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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Adrenergic signaling in cardiomyocytes
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Vascular smooth muscle contraction
|
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Salivary secretionhsa04020:Calcium signaling pathway
|
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Salivary secretionhsa04024:cAMP signaling pathway
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Serotonergic synapsehsa04020:Calcium signaling pathway
|
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Gap junction
|
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Serotonergic synapse
|
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Inflammatory mediator regulation of TRP channelshsa04015:Rap1 signaling pathway
|
|
cAMP signaling pathway
|
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Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Alcoholismhsa04020:Calcium signaling pathway
|
|
AMPK signaling pathway
|
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Salivary secretion
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
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PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00002:Alpha adrenergic receptor signaling pathway
|
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Pathway Interaction Database
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LPA receptor mediated events
|
|
Reactome
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Adrenoceptors
|
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G alpha (q) signalling events
|
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G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
|
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G alpha (12/13) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
|
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G alpha (12/13) signalling events
|
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WikiPathways
|
Monoamine GPCRs
|
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Calcium Regulation in the Cardiac Cell
|
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GPCRs, Class A Rhodopsin-like
|
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Vitamin D Receptor Pathway
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signaling
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AMPK SignalingWP58:Monoamine GPCRs
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GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
|
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Endothelin Pathways
|
|
AMPK Signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 101). |
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| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000562) |
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| REF 3 | J Med Chem. 1996 Jan 5;39(1):143-8.3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. |
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| REF 4 | J Med Chem. 1991 Nov;34(11):3316-28.Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone. |
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