Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D7QO
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| Former ID |
DIB013991
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| Drug Name |
Phenylephrine hydrochloride gel
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| Synonyms |
Incostop; Phenylephrine hydrochloride; Phenylephrine hydrochloride gel (fecal incontinence); VEN-308; Phenylephrine hydrochloride gel (fecal incontinence), SLA Pharma/Ventrus Biosciences; 10% phenylephrine HCl cream, Solvay/SLA Pharma; 20% phenylephrine HCl cream, Solvay/SLA Pharma
|
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| Indication | Fecal incontinence [ICD10:R15] | Approved | [1] | ||
| Company |
SLA Pharma UK Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(cc(O)ccc1)[C@@H](O)CNC.Cl
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| CAS Number |
CAS 61-76-7
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| Target and Pathway | |||||
| Target(s) | Alpha-1D adrenergic receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Salivary secretion | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019494) | ||||
| REF 2 | Effects of topically instilled bunazosin, an alpha1-adrenoceptor antagonist, on constrictions induced by phenylephrine and ET-1 in rabbit retinal arteries. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4041-8. | ||||
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