| Drug General Information |
| Drug ID |
D0E9VU
|
| Former ID |
DNC012645
|
| Drug Name |
LEVONORDEFRIN
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H13NO3
|
| InChI |
InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
|
| InChIKey |
GEFQWZLICWMTKF-CDUCUWFYSA-N
|
| CAS Number |
CAS 829-74-3
|
| PubChem Compound ID |
|
| PubChem Substance ID |
13932, 7849447, 8149401, 10255593, 11111073, 11112447, 11335490, 11360729, 11364536, 11367098, 11369660, 11371540, 11373602, 11377822, 11461701, 11484746, 11488871, 11490296, 11491847, 11495456, 15947283, 24277784, 26611796, 26679431, 46238888, 47216686, 47365101, 47885314, 48110365, 48334396, 48334397, 48479897, 49699157, 50065272, 50100443, 50100444, 57350546, 57654107, 79290449, 92124111, 92307503, 99301403, 99443259, 103190505, 103938162, 113454748, 121363335, 124550756, 124637940, 124882389
|
| Target and Pathway |
| Target(s) |
Alpha-1D adrenergic receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Alpha-1B adrenergic receptor |
Target Info |
Inhibitor |
[2]
|
| Alpha-1A adrenergic receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Adrenergic signaling in cardiomyocytes
|
|
Vascular smooth muscle contraction
|
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Salivary secretionhsa04020:Calcium signaling pathway
|
|
AMPK signaling pathway
|
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Salivary secretion
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
|
Pathway Interaction Database
|
LPA receptor mediated events
|
|
Reactome
|
Adrenoceptors
|
|
G alpha (q) signalling events
|
|
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
|
|
G alpha (12/13) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
GPCRs, Class A Rhodopsin-like
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR ligand binding
|
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GPCR downstream signaling
|
|
GPCRs, OtherWP58:Monoamine GPCRs
|
|
Vitamin D Receptor Pathway
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AMPK SignalingWP58:Monoamine GPCRs
|
|
Endothelin Pathways
|
|
AMPK Signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 508). |
|---|
| REF 2 | J Med Chem. 1996 Jul 19;39(15):3001-13.Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine. |
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