| Drug General Information |
| Drug ID |
D06HHJ
|
| Former ID |
DNC004340
|
| Drug Name |
(2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H8BrN3
|
| Canonical SMILES |
C1=CC=C(C(=C1)NC2=NC=CN2)Br
|
| InChI |
1S/C9H8BrN3/c10-7-3-1-2-4-8(7)13-9-11-5-6-12-9/h1-6H,(H2,11,12,13)
|
| InChIKey |
KHNAVCNEASQADL-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-1D adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha-2C adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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Adrenergic signaling in cardiomyocytes
|
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Vascular smooth muscle contraction
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Salivary secretionhsa04022:cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
|
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AMPK signaling pathway
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Salivary secretion
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NetPath Pathway
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
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Pathway Interaction Database
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LPA receptor mediated events
|
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Reactome
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Adrenoceptors
|
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G alpha (q) signalling events
|
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G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
|
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Adrenaline signalling through Alpha-2 adrenergic receptor
|
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Adrenaline,noradrenaline inhibits insulin secretion
|
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G alpha (i) signalling events
|
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G alpha (z) signalling events
|
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Surfactant metabolismR-HSA-390696:Adrenoceptors
|
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G alpha (12/13) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
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Calcium Regulation in the Cardiac Cell
|
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GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
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Platelet Aggregation (Plug Formation)
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Integration of energy metabolism
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GPCR downstream signalingWP58:Monoamine GPCRs
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Endothelin Pathways
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AMPK SignalingWP58:Monoamine GPCRs
|
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Vitamin D Receptor Pathway
|
|
AMPK Signaling
|
| References |
| REF 1 | J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. |
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