Drug General Information
Drug ID	D0H3CW
Former ID	DNC003954
Drug Name	SK&F-105854
Synonyms	SK-105854
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[468241]
Structure		Download 2D MOL 3D MOL
Formula	C12H11BrClNO
InChI	InChI=1S/C12H11BrClNO/c1-15-5-4-7-9(14)2-3-10-11(7)8(6-15)12(13)16-10/h2-3H,4-6H2,1H3
InChIKey	NYGANYRUZQPPGP-UHFFFAOYSA-N
PubChem Compound ID	9839317
PubChem Substance ID	14800486, 24137894, 44937403, 80889221, 85209304, 103352066, 103939468, 128771761, 134341159, 135651047, 234789846
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[533638]
	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[527393]
	Alpha-1B adrenergic receptor	Target Info	Inhibitor	[533638]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04020:Calcium signaling pathway
	AMPK signaling pathway
	Salivary secretion
NetPath Pathway	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database	LPA receptor mediated events
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Endothelin Pathways
	AMPK SignalingWP58:Monoamine GPCRs
	Vitamin D Receptor Pathway
	AMPK Signaling
References
Ref 468241	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 518).
Ref 527393	Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64.Pharmacophore identification of alpha(1A)-adrenoceptor antagonists.
Ref 533638	J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

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