| Drug General Information |
| Drug ID |
D06UBB
|
| Former ID |
DNC003956
|
| Drug Name |
SK&F-86466
|
| Synonyms |
SK-86466
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H14ClN
|
| Canonical SMILES |
CN1CCC2=C(CC1)C(=CC=C2)Cl
|
| InChI |
1S/C11H14ClN/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13/h2-4H,5-8H2,1H3
|
| InChIKey |
RSRUDTPYRBLHEO-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-1A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha-1D adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
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cGMP-PKG signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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AMPK signaling pathway
|
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Adrenergic signaling in cardiomyocytes
|
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Vascular smooth muscle contraction
|
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Salivary secretionhsa04020:Calcium signaling pathway
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Salivary secretion
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NetPath Pathway
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IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
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PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
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Pathway Interaction Database
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LPA receptor mediated events
|
|
Reactome
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Adrenoceptors
|
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G alpha (q) signalling events
|
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G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
|
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G alpha (12/13) signalling events
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WikiPathways
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Monoamine GPCRs
|
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Calcium Regulation in the Cardiac Cell
|
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GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Endothelin Pathways
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GPCR ligand binding
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GPCR downstream signaling
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AMPK SignalingWP58:Monoamine GPCRs
|
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GPCRs, OtherWP58:Monoamine GPCRs
|
|
Vitamin D Receptor Pathway
|
|
AMPK Signaling
|
| References |
| REF 1 | J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. |
|---|
