| Drug General Information |
| Drug ID |
D0L9WN
|
| Former ID |
DNC012349
|
| Drug Name |
4-(4-Methyl-indan-1-yl)-1H-imidazole
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H14N2
|
| Canonical SMILES |
CC1=CC=CC2=C1CCC2C3=CN=CN3
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| InChI |
1S/C13H14N2/c1-9-3-2-4-11-10(9)5-6-12(11)13-7-14-8-15-13/h2-4,7-8,12H,5-6H2,1H3,(H,14,15)
|
| InChIKey |
XXQLSAWUSXSJTK-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-1D adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-2C adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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Calcium signaling pathway
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cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interaction
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Adrenergic signaling in cardiomyocytes
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Vascular smooth muscle contraction
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Salivary secretionhsa04022:cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
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Salivary secretionhsa04020:Calcium signaling pathway
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AMPK signaling pathway
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NetPath Pathway
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IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Pathway Interaction Database
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LPA receptor mediated events
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Reactome
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Adrenoceptors
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G alpha (q) signalling events
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G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
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Adrenaline signalling through Alpha-2 adrenergic receptor
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G alpha (i) signalling events
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
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Adrenaline,noradrenaline inhibits insulin secretion
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G alpha (z) signalling events
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Surfactant metabolismR-HSA-390696:Adrenoceptors
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Surfactant metabolism
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WikiPathways
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Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
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Platelet Aggregation (Plug Formation)
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GPCR downstream signalingWP58:Monoamine GPCRs
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Integration of energy metabolism
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Vitamin D Receptor Pathway
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AMPK SignalingWP58:Monoamine GPCRs
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Endothelin Pathways
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| References |
| REF 1 | J Med Chem. 1997 Sep 12;40(19):3014-24.Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket". |
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