Drug Information

Drug General Information
Drug ID
D0S1GH
Former ID
DNC012808
Drug Name
4-Morpholin-2-yl-benzene-1,2-diol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526729]
Structure
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2D MOL

3D MOL
Formula
C10H13NO3
Canonical SMILES
C1COC(CN1)C2=CC(=C(C=C2)O)O
InChI
1S/C10H13NO3/c12-8-2-1-7(5-9(8)13)10-6-11-3-4-14-10/h1-2,5,10-13H,3-4,6H2
InChIKey
GYJRRQRGZZEHEB-UHFFFAOYSA-N
PubChem Compound ID
3042920
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [526729]
Alpha-1B adrenergic receptor Target Info Inhibitor [526729]
Alpha-1D adrenergic receptor Target Info Inhibitor [526729]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
GPCRs, Other
References
Ref 526729J Med Chem. 1992 Mar 20;35(6):1009-18.Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.
Ref 526729J Med Chem. 1992 Mar 20;35(6):1009-18.Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.

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