Drug General Information
Drug ID	D0P5PW
Former ID	DNC004570
Drug Name	4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533805]
Structure		Download 2D MOL 3D MOL
Formula	C15H14N2
Canonical SMILES	CC(C1=CC=CC2=CC=CC=C21)C3=CN=CN3
InChI	1S/C15H14N2/c1-11(15-9-16-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13/h2-11H,1H3,(H,16,17)
InChIKey	DZSQSLQSMKNVBV-UHFFFAOYSA-N
PubChem Compound ID	132111
Target and Pathway
Target(s)	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[533805]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[533805]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[533805]
	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[533805]
	Alpha-1B adrenergic receptor	Target Info	Inhibitor	[533805]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[533805]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	AMPK signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	Salivary secretionhsa04020:Calcium signaling pathway
NetPath Pathway	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database	LPA receptor mediated events
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (i) signalling events
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	AMPK SignalingWP58:Monoamine GPCRs
	Platelet Aggregation (Plug Formation)
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	GPCRs, OtherWP58:Monoamine GPCRs
	Vitamin D Receptor Pathway
References
Ref 533805	J Med Chem. 1994 Jul 22;37(15):2328-33.A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.
Ref 533805	J Med Chem. 1994 Jul 22;37(15):2328-33.A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.

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