Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T15739 Target Info
Target Name Cellular tumor antigen p53 (TP53)
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Target Type Clinical trial Target
Gene Name TP53
UniProt ID
P04637
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-300 miRNA Info
miRNA Mature AC
MIMAT0004903
Sequence uauacaagggcagacucucucu
miRNA Species Homo sapiens
Regulation Mechanism Overexpression of miR-300 with mimi repressed p53 expression and miR-300 knockdown by AS dramatically enhanced p53 expression indicating that endogenous miR-300 regulates p53 abundance. [3]
Evidence Score (E-score) 3 +
1 Immunoprecipitation; Luciferase Reporter Assay; qRT-PCR; Western Blot [1]
2 Luciferase Reporter Assay; qRT-PCR; Western Blot [2]
3 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Bromodomain-containing protein 7 (BRD7) Target Info
BRD7_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-34a-5p miRNA Info
miRNA Mature AC
MIMAT0000255
Sequence uggcagugucuuagcugguugu
miRNA Species Homo sapiens
Regulation Mechanism Members of miR-34 family, including miR-34a, b and c, were reported as direct targets of p53 protein. [5]
Evidence Score (E-score) 3 +
1 Immunoblot; Luciferase Reporter Assay; Microarray; Northern Blot; qRT-PCR [4]
2 Immunohistochemistry; Immunocytochemistry [5]
3 qRT-PCR; Western Blot [6]
Representative Target(s) Regulated by This miRNA Amphiregulin (AREG) Target Info
AREG_HUMAN
Androgen receptor (AR) Target Info
ANDR_HUMAN
miRNA Mature ID hsa-miR-106b-5p miRNA Info
miRNA Mature AC
MIMAT0000680
Sequence uaaagugcugacagugcagau
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [7]
2 qRT-PCR [8]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
miRNA Mature ID hsa-miR-125a-5p miRNA Info
miRNA Mature AC
MIMAT0000443
Sequence ucccugagacccuuuaaccuguga
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-125a-5p by mature miRNA precursor transfection resulted in the decreased protein level of target TP53. [9]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Northern Blot; qRT-PCR; Western Blot [9]
2 qRT-PCR; Western Blot [10]
Representative Target(s) Regulated by This miRNA Apoptosis regulator BAK (BAK) Target Info
BAK_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-150-5p miRNA Info
miRNA Mature AC
MIMAT0000451
Sequence ucucccaacccuuguaccagug
miRNA Species Homo sapiens
Regulation Mechanism miR-150 directly targets the p53 gene by interaction with the 3'UTR. [11]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [11]
2 Luciferase Reporter Assay; Western Blot [12]
Representative Target(s) Regulated by This miRNA Apoptosis inhibitor survivin (BIRC5) Target Info
BIRC5_HUMAN
Beta-arrestin-2 (ARRB2) Target Info
ARRB2_HUMAN
miRNA Mature ID hsa-miR-155-3p miRNA Info
miRNA Mature AC
MIMAT0004658
Sequence cuccuacauauuagcauuaaca
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [13]
2 Luciferase Reporter Assay; Western Blot [14]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Erbb2 tyrosine kinase receptor (HER2) Target Info
ERBB2_HUMAN
miRNA Mature ID hsa-miR-15a-5p miRNA Info
miRNA Mature AC
MIMAT0000068
Sequence uagcagcacauaaugguuugug
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 HITS-CLIP [15]
2 Immunoblot; Luciferase Reporter Assay [16]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-18a-5p miRNA Info
miRNA Mature AC
MIMAT0000072
Sequence uaaggugcaucuagugcagauag
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 qRT-PCR [8]
2 RT-PCR [17]
Representative Target(s) Regulated by This miRNA Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-214-3p miRNA Info
miRNA Mature AC
MIMAT0000271
Sequence acagcaggcacagacaggcagu
miRNA Species Homo sapiens
Regulation Mechanism miR-214 directly interacts with the 3' UTR of p53. [19]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [18]
2 Reporter Assay [19]
Representative Target(s) Regulated by This miRNA Activating transcription factor 4 (ATF-4) Target Info
ATF4_HUMAN
ADP-ribosylation factor-like protein 2 (ARL2) Target Info
ARL2_HUMAN
miRNA Mature ID hsa-miR-214-5p miRNA Info
miRNA Mature AC
MIMAT0004564
Sequence ugccugucuacacuugcugugc
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [20]
2 qRT-PCR; Western Blot [21]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Cyclin-dependent kinase 3 (CDK3) Target Info
CDK3_HUMAN
miRNA Mature ID hsa-miR-221-3p miRNA Info
miRNA Mature AC
MIMAT0000278
Sequence agcuacauugucugcuggguuuc
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [22]
2 Western Blot [23]
Representative Target(s) Regulated by This miRNA Bcl-2-binding component 3 (BBC3) Target Info
BBC3_HUMAN
Beclin-1 (BECN1) Target Info
BECN1_HUMAN
miRNA Mature ID hsa-miR-27a-3p miRNA Info
miRNA Mature AC
MIMAT0000084
Sequence uucacaguggcuaaguuccgc
miRNA Species Homo sapiens
Regulation Mechanism miR-27a is binding directly to the p53 30-UTR. [25]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [24]
2 qRT-PCR [25]
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter A1 (ABCA1) Target Info
ABCA1_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-30d-5p miRNA Info
miRNA Mature AC
MIMAT0000245
Sequence uguaaacauccccgacuggaag
miRNA Species Homo sapiens
Regulation Mechanism miR-30 directly target the 3'UTR of TP53 to downregulate p53 protein levels and reduce the expression of genes that are transcriptionally activated by p53. [27]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; qRT-PCR; Western Blot [26]
2 Luciferase Reporter Assay; Western Blot [27]
Representative Target(s) Regulated by This miRNA Autophagy-related 2B (ATG2B) Target Info
ATG2B_HUMAN
Beclin-1 (BECN1) Target Info
BECN1_HUMAN
miRNA Mature ID hsa-miR-377-3p miRNA Info
miRNA Mature AC
MIMAT0000730
Sequence aucacacaaaggcaacuuuugu
miRNA Species Homo sapiens
Regulation Mechanism miR-377 downregulated p53, expression by directly targeting the 3'-untranslated region of TP53. [28]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [28]
2 Luciferase Reporter Assay; Western Blot; RT-PCR [28]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
DNA [cytosine-5]-methyltransferase 1 (DNMT1) Target Info
DNMT1_HUMAN
miRNA Mature ID hsa-miR-638 miRNA Info
miRNA Mature AC
MIMAT0003308
Sequence agggaucgcgggcggguggcggccu
miRNA Species Homo sapiens
Regulation Mechanism Inhibition of endogenous miR-638 resulted in a significant upregulation p53 protein levels. [29]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [29]
2 qRT-PCR [30]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Cyclin-dependent kinase 2 (CDK2) Target Info
CDK2_HUMAN
miRNA Mature ID hsa-miR-151a-5p miRNA Info
miRNA Mature AC
MIMAT0004697
Sequence ucgaggagcucacagucuagu
miRNA Species Homo sapiens
Regulation Mechanism miR-151-5p could target 3'-untranslated region (3'UTR) of p53 mRNA and downregulate p53 level in SC-M1 cells. [31]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay; Western Blot [31]
2 Luciferase Reporter Assay; Western Blot [32]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Thrombopoietin receptor (MPL) Target Info
TPOR_HUMAN
miRNA Mature ID hsa-miR-605-5p miRNA Info
miRNA Mature AC
MIMAT0003273
Sequence uaaaucccauggugccuucuccu
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 qRT-PCR [33]
2 Reporter Assay [19]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Gankyrin (PSMD10) Target Info
PSD10_HUMAN
miRNA Mature ID hsa-miR-106a-5p miRNA Info
miRNA Mature AC
MIMAT0000103
Sequence aaaagugcuuacagugcagguag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR [8]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
miRNA Mature ID hsa-miR-10b-5p miRNA Info
miRNA Mature AC
MIMAT0000254
Sequence uacccuguagaaccgaauuugug
miRNA Species Homo sapiens
Regulation Mechanism miRNA-10b is a target gene of TP53 to regulate invasiveness of U87-2M1 glioma cells. [34]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [34]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Cyclic AMP-responsive element-binding protein (CREB1) Target Info
CREB1_HUMAN
miRNA Mature ID hsa-miR-17-5p miRNA Info
miRNA Mature AC
MIMAT0000070
Sequence caaagugcuuacagugcagguag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR [8]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
miRNA Mature ID hsa-miR-200a-3p miRNA Info
miRNA Mature AC
MIMAT0000682
Sequence uaacacugucugguaacgaugu
miRNA Species Homo sapiens
Regulation Mechanism miR-200a caused a significant down- regulation of p53 protein levels in cells with a WT 3'UTR. [35]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [35]
Representative Target(s) Regulated by This miRNA Amphiregulin (AREG) Target Info
AREG_HUMAN
Beta-catenin (CTNNB1) Target Info
CTNB1_HUMAN
miRNA Mature ID hsa-miR-20a-5p miRNA Info
miRNA Mature AC
MIMAT0000075
Sequence uaaagugcuuauagugcagguag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR [8]
Representative Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Target Info
A4_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-222-3p miRNA Info
miRNA Mature AC
MIMAT0000279
Sequence agcuacaucuggcuacugggu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Western Blot [23]
Representative Target(s) Regulated by This miRNA AN1-type zinc finger protein 5 (ZFAND5) Target Info
ZFAN5_HUMAN
ATP-binding cassette transporter G2 (ABCG2) Target Info
ABCG2_HUMAN
miRNA Mature ID hsa-miR-25-3p miRNA Info
miRNA Mature AC
MIMAT0000081
Sequence cauugcacuugucucggucuga
miRNA Species Homo sapiens
Regulation Mechanism miR-25 directly target the 3'UTR of TP53 to downregulate p53 protein levels and reduce the expression of genes that are transcriptionally activated by p53. [27]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [27]
Representative Target(s) Regulated by This miRNA CDK inhibitor 1C p57Kip2 (CDKN1C) Target Info
CDN1C_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-26a-1-3p miRNA Info
miRNA Mature AC
MIMAT0004499
Sequence ccuauucuugguuacuugcacg
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR; Western Blot [36]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Caspase-3 (CASP3) Target Info
CASP3_HUMAN
miRNA Mature ID hsa-miR-28-5p miRNA Info
miRNA Mature AC
MIMAT0000085
Sequence aaggagcucacagucuauugag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [37]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Extracellular signal-regulated kinase 2 (ERK2) Target Info
MK01_HUMAN
miRNA Mature ID hsa-miR-30a-5p miRNA Info
miRNA Mature AC
MIMAT0000087
Sequence uguaaacauccucgacuggaag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [26]
Representative Target(s) Regulated by This miRNA Beclin-1 (BECN1) Target Info
BECN1_HUMAN
Brain-derived neurotrophic factor (BDNF) Target Info
BDNF_HUMAN
miRNA Mature ID hsa-miR-30b-5p miRNA Info
miRNA Mature AC
MIMAT0000420
Sequence uguaaacauccuacacucagcu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [26]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Beclin-1 (BECN1) Target Info
BECN1_HUMAN
miRNA Mature ID hsa-miR-30e-5p miRNA Info
miRNA Mature AC
MIMAT0000692
Sequence uguaaacauccuugacuggaag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [26]
Representative Target(s) Regulated by This miRNA Caspase-3 (CASP3) Target Info
CASP3_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-491-5p miRNA Info
miRNA Mature AC
MIMAT0002807
Sequence aguggggaacccuuccaugagg
miRNA Species Homo sapiens
Regulation Mechanism Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited endogenous Bcl-XL TP53 gene expressions. [38]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [38]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-xL (BCL-xL) Target Info
B2CL1_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-504-5p miRNA Info
miRNA Mature AC
MIMAT0002875
Sequence agacccuggucugcacucuauc
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Reporter Assay; Western Blot [25]
Representative Target(s) Regulated by This miRNA Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
Bcl-2-binding component 3 (BBC3) Target Info
BBC3_HUMAN
miRNA Mature ID hsa-miR-663a miRNA Info
miRNA Mature AC
MIMAT0003326
Sequence aggcggggcgccgcgggaccgc
miRNA Species Homo sapiens
Regulation Mechanism ZNF224 increased miR-663a transcription by binding to miR-663a promoter, which in turn bound to 3'UTR of p53 and p21 to decrease their expression. [39]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [39]
Representative Target(s) Regulated by This miRNA C-X-C chemokine receptor type 4 (CXCR4) Target Info
CXCR4_HUMAN
CCAAT/enhancer binding protein beta (CEBPB) Target Info
CEBPB_HUMAN
miRNA Mature ID hsa-miR-92a-1-5p miRNA Info
miRNA Mature AC
MIMAT0004507
Sequence agguugggaucgguugcaaugcu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR [8]
Representative Target(s) Regulated by This miRNA Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-1228-3p miRNA Info
miRNA Mature AC
MIMAT0005583
Sequence ucacaccugccucgcccccc
miRNA Species Homo sapiens
Regulation Mechanism Ectopic expression of miR-1228 decreased the amount of p53 mRNA and protein. [40]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Immunohistochemistry; Western Blot [40]
Representative Target(s) Regulated by This miRNA BMP-2-inducible protein kinase (BMP2K) Target Info
BMP2K_HUMAN
Casein kinase II alpha prime (CSNK2A2) Target Info
CSK22_HUMAN
miRNA Mature ID hsa-miR-125b-1-3p miRNA Info
miRNA Mature AC
MIMAT0004592
Sequence acggguuaggcucuugggagcu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [41]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
ERK activator kinase 7 (MAP2K7) Target Info
MP2K7_HUMAN
miRNA Mature ID hsa-miR-150-3p miRNA Info
miRNA Mature AC
MIMAT0004610
Sequence cugguacaggccugggggacag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR; Western Blot [42]
Representative Target(s) Regulated by This miRNA Beta-catenin (CTNNB1) Target Info
CTNB1_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-485-5p miRNA Info
miRNA Mature AC
MIMAT0002175
Sequence agaggcuggccgugaugaauuc
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR [25]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Frizzled-7 receptor (FZD7) Target Info
FZD7_HUMAN
miRNA Mature ID hsa-miR-518c-3p miRNA Info
miRNA Mature AC
MIMAT0002848
Sequence caaagcgcuucucuuuagagugu
miRNA Species Homo sapiens
Regulation Mechanism Overexpression of miR-518c-3p downregulated the expression of 5'UTR plus coding sequence (CDS) constructs, suggesting that their effect on p53 is partly 3'UTR independent. [29]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [29]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) Target Info
DHB1_HUMAN
miRNA Mature ID hsa-miR-608 miRNA Info
miRNA Mature AC
MIMAT0003276
Sequence aggggugguguugggacagcuccgu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR [25]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-xL (BCL-xL) Target Info
B2CL1_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-612 miRNA Info
miRNA Mature AC
MIMAT0003280
Sequence gcugggcagggcuucugagcuccuu
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [43]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
RAC-beta serine/threonine-protein kinase (AKT2) Target Info
AKT2_HUMAN
miRNA Mature ID hsa-miR-92a-2-5p miRNA Info
miRNA Mature AC
MIMAT0004508
Sequence ggguggggauuuguugcauuac
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 qRT-PCR [8]
Representative Target(s) Regulated by This miRNA Apoptosis mediating surface antigen FAS (FAS) Target Info
TNR6_HUMAN
Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-1285-3p miRNA Info
miRNA Mature AC
MIMAT0005876
Sequence ucugggcaacaaagugagaccu
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-1285-3p by mature miRNA mimics tranfection resulted in the decreased protein level of target TP53. [9]
Evidence Score (E-score) 1 +
1 Western Blot; qRT-PCR; Luciferase Reporter Assay [9]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
miRNA Mature ID hsa-miR-28-3p miRNA Info
miRNA Mature AC
MIMAT0004502
Sequence cacuagauugugagcuccugga
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [37]
Representative Target(s) Regulated by This miRNA Cellular tumor antigen p53 (TP53) Target Info
P53_HUMAN
References  Top
REF 1 The up-regulation of miR-300 in gastric cancer and its effects on cells malignancy. Int J Clin Exp Med. 2015 May 15;8(5):6773-83.
REF 2 miR-300 promotes proliferation and EMT-mediated colorectal cancer migration and invasion by targeting p53. Oncol Rep. 2016 Dec;36(6):3225-3232.
REF 3 MiR-300 regulate the malignancy of breast cancer by targeting p53. Int J Clin Exp Med. 2015 May 15;8(5):6957-66.
REF 4 miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS One. 2015 Jul 15;10(7):e0132767.
REF 5 Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis. Med Oncol. 2013 Mar;30(1):413.
REF 6 Aptamer-Dendrimer Bioconjugates for Targeted Delivery of miR-34a Expressing Plasmid and Antitumor Effects in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Sep 25;10(9):e0139136.
REF 7 miR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis. Stem Cell Res Ther. 2019 Sep 23;10(1):282.
REF 8 Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences. Genes Cancer. 2014 Apr;5(1-2):56-63.
REF 9 MicroRNA 125a and its regulation of the p53 tumor suppressor gene. FEBS Lett. 2009 Nov 19;583(22):3725-30.
REF 10 HasiR 25a and 125b are induced by treatment with cisplatin in nasopharyngeal carcinoma and inhibit apoptosis in a p53ependent manner by targeting p53 mRNA. Mol Med Rep. 2015 Sep;12(3):3569-3574.
REF 11 miR-150, p53 protein and relevant miRNAs consist of a regulatory network in NSCLC tumorigenesis. Oncol Rep. 2013 Jul;30(1):492-8.
REF 12 miR-150 promotes the proliferation of lung cancer cells by targeting P53. FEBS Lett. 2013 Aug 2;587(15):2346-51.
REF 13 Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers. Clin Cancer Res. 2017 Jun 1;23(11):2891-2904.
REF 14 Sponges against miR-19 and miR-155 reactivate the p53-Socs1 axis in hematopoietic cancers. Cytokine. 2016 Jun;82:80-6.
REF 15 Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. Genes Dev. 2013 Jul 15;27(14):1624-32.
REF 16 Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA. 2011 Jan 5;305(1):59-67.
REF 17 Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-alpha in female hepatocellular carcinoma. Int J Cancer. 2015 Feb 15;136(4):761-70.
REF 18 MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog. J Biol Chem. 2012 Oct 12;287(42):34970-8.
REF 19 miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. EMBO J. 2011 Feb 2;30(3):524-32.
REF 20 A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. Sci Rep. 2014 Sep 18;4:6413.
REF 21 Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of miR-214 and regulation of p53 and Bcl-2/Bax. Oncol Rep. 2015 Jun;33(6):3061-8.
REF 22 p53/mdm2 feedback loop sustains miR-221 expression and dictates the response to anticancer treatments in hepatocellular carcinoma. Mol Cancer Res. 2014 Feb;12(2):203-16.
REF 23 miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. J Oral Pathol Med. 2011 Aug;40(7):560-6.
REF 24 The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nat Commun. 2015 Dec 21;6:10077.
REF 25 Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell. 2010 Jun 11;38(5):689-99.
REF 26 Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids. J Am Soc Nephrol. 2014 Jan;25(1):92-104.
REF 27 Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene. 2011 Feb 17;30(7):843-53.
REF 28 MicroRNA-377 predicts poor clinical outcome of gastric cancer and induces tumorigenesis by targeting multiple tumor-suppressor genes. Oncol Rep. 2015 Jul;34(1):203-10.
REF 29 Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. Cell Rep. 2014 Aug 7;8(3):714-22.
REF 30 Comparison of N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase activities for evaluation of microangiopathy in diabetes mellitus. Metabolism. 1987 Mar;36(3):277-80.
REF 31 Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget. 2016 Jun 21;7(25):38036-38051.
REF 32 Identification of new p53 target microRNAs by bioinformatics and functional analysis. BMC Cancer. 2013 Nov 21;13:552.
REF 33 A functional variant in miR-605 modifies the age of onset in Li-Fraumeni syndrome. Cancer Genet. 2015 Jan-Feb;208(1-2):47-51.
REF 34 MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. Cell Death Dis. 2012 Oct 4;3:e398.
REF 35 A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways. PLoS One. 2012;7(11):e48474.
REF 36 The Antitumor Effect of Metformin Is Mediated by miR-26a in Breast Cancer. Int J Mol Sci. 2016 Aug 10;17(8). pii: E1298.
REF 37 Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene. 2015 Mar 5;34(10):1323-32.
REF 38 MicroRNA miR-491-5p targeting both TP53 and Bcl-XL induces cell apoptosis in SW1990 pancreatic cancer cells through mitochondria mediated pathway. Molecules. 2012 Dec 11;17(12):14733-47.
REF 39 ZNF224, Krpel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a. Oncotarget. 2016 May 24;7(21):31177-90.
REF 40 miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop. Br J Cancer. 2015 Jan 20;112(2):365-74.
REF 41 Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress. RNA Biol. 2016 Nov;13(11):1152-1165.
REF 42 Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth. PLoS One. 2016 Apr 15;11(4):e0153689.
REF 43 MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3' untranslated region. Biochem Biophys Res Commun. 2010 May 28;396(2):435-9.

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