miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-200a-3p | ||||
miRNA Stemloop AC | MI0000737 | ||||
miRNA Stemloop ID | hsa-mir-200a | ||||
Sequence | uaacacugucugguaacgaugu | ||||
TTD Target(s) Regulated by This miRNA | Epidermal growth factor receptor (EGFR) | Successful Target | Target Info | [1] | |
Cyclin-dependent kinase 6 (CDK6) | Successful Target | Target Info | [2] | ||
Signal transducer and activator of transcription 3 (STAT3) | Successful Target | Target Info | [3] | ||
Thyroid hormone receptor beta (THRB) | Successful Target | Target Info | [4] | ||
Beta-catenin (CTNNB1) | Successful Target | Target Info | [5] | ||
Stress-activated protein kinase 2a (p38 alpha) | Clinical trial Target | Target Info | [6] | ||
Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [7] | ||
DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | Target Info | [8] | ||
Enhancer of zeste homolog 2 (EZH2) | Successful Target | Target Info | [8] | ||
Hepatocyte growth factor (HGF) | Clinical trial Target | Target Info | [9] | ||
Transforming growth factor beta 2 (TGFB2) | Clinical trial Target | Target Info | [10] | ||
Gap junction alpha-1 protein (GJA1) | Clinical trial Target | Target Info | [11] | ||
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [12] | ||
High mobility group protein B1 (HMGB1) | Literature-reported Target | Target Info | [13] | ||
Transferrin receptor protein 1 (TFRC) | Clinical trial Target | Target Info | [14] | ||
Amphiregulin (AREG) | Literature-reported Target | Target Info | [15] | ||
DEK protein (DEK) | Literature-reported Target | Target Info | [16] | ||
Yes-associated protein 1 (YAP1) | Literature-reported Target | Target Info | [17] | ||
Zinc finger E-box-binding homeobox 2 (ZEB2) | Literature-reported Target | Target Info | [18] | ||
G1/S-specific cyclin-E2 (CCNE2) | Literature-reported Target | Target Info | [19] | ||
Mothers against decapentaplegic homolog 3 (SMAD3) | Preclinical Target | Target Info | [20] | ||
Protein(s) Regulated by This miRNA | 26S proteasome non-ATPase regulatory subunit 2 | Regulated Protein | [21] | ||
C-Jun-amino-terminal kinase-interacting protein 4 | Regulated Protein | [22] | |||
Engulfment and cell motility protein 2 | Regulated Protein | [23] | |||
Erbin | Regulated Protein | [23] | |||
Ganglioside-induced differentiation-associated protein 1 | Regulated Protein | [24] | |||
Gem-associated protein 2 | Regulated Protein | [25] | |||
Hepatocyte nuclear factor 3-beta | Regulated Protein | [26] | |||
Hereditary hemochromatosis protein | Regulated Protein | [27] | |||
Homeobox protein DLX-5 | Regulated Protein | [28] | |||
Homeobox protein Hox-B5 | Regulated Protein | [23] | |||
Kelch-like protein 20 | Regulated Protein | [23] | |||
Krueppel-like factor 11 | Regulated Protein | [23] | |||
Metastasis-associated in colon cancer protein 1 | Regulated Protein | [29] | |||
Mitochondrial fission factor | Regulated Protein | [30] | |||
Mothers against decapentaplegic homolog 2 | Regulated Protein | [20] | |||
Motor neuron and pancreas homeobox protein 1 | Regulated Protein | [32] | |||
Myosin-10 | Regulated Protein | [33] | |||
Programmed cell death protein 4 | Regulated Protein | [4] | |||
Protein VAC14 homolog | Regulated Protein | [23] | |||
Protocadherin-8 | Regulated Protein | [21] | |||
Ras and Rab interactor 2 | Regulated Protein | [23] | |||
Ras association domain-containing protein 2 | Regulated Protein | [23] | |||
Ras GTPase-activating protein-binding protein 2 | Regulated Protein | [21] | |||
Ras-related protein Rab-30 | Regulated Protein | [21] | |||
Receptor-type tyrosine-protein phosphatase delta | Regulated Protein | [23] | |||
Rho GTPase-activating protein 7 | Regulated Protein | [27] | |||
Septin-7 | Regulated Protein | [23] | |||
Serum response factor | Regulated Protein | [35] | |||
SHC-transforming protein 1 | Regulated Protein | [23] | |||
Trafficking protein particle complex subunit 2B | Regulated Protein | [36] | |||
Transcription factor 7-like 1 | Regulated Protein | [23] | |||
Transcription factor A, mitochondrial | Regulated Protein | [37] | |||
Transcriptional regulator ATRX | Regulated Protein | [27] | |||
Ubiquitin carboxyl-terminal hydrolase BAP1 | Regulated Protein | [23] | |||
Ubiquitin-associated and SH3 domain-containing protein B | Regulated Protein | [38] | |||
WD repeat-containing protein 37 | Regulated Protein | [23] | |||
Wiskott-Aldrich syndrome protein family member 3 | Regulated Protein | [39] | |||
Zinc finger E-box-binding homeobox 1 | Regulated Protein | [18] | |||
Zinc finger protein ZFPM2 | Regulated Protein | [23] | |||
References | |||||
REF 1 | XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. J Hematol Oncol. 2017 Jan 5;10(1):6. | ||||
REF 2 | microRNA-200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6. Oncol Rep. 2013 Nov;30(5):2203-10. | ||||
REF 3 | MicroRNA-29a promotes apoptosis of monocytes by targeting STAT3 during sepsis. Genet Mol Res. 2015 Oct 29;14(4):13746-53. | ||||
REF 4 | MicroRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB. Br J Haematol. 2017 Jan;176(1):50-64. | ||||
REF 5 | Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol Cell Biol. 2009 Nov;29(21):5923-40. | ||||
REF 6 | miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med. 2011 Nov 20;17(12):1627-35. | ||||
REF 7 | A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways. PLoS One. 2012;7(11):e48474. | ||||
REF 8 | DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression. Cancer Lett. 2015 Apr 10;359(2):198-205. | ||||
REF 9 | MiRNA-200a expression is inverse correlation with hepatocyte growth factor expression in stromal fibroblasts and its high expression predicts a good prognosis in patients with non-small cell lung cancer. Oncotarget. 2016 Jul 26;7(30):48432-48442. | ||||
REF 10 | Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a. J Exp Clin Cancer Res. 2016 Jun 6;35(1):90. | ||||
REF 11 | Identification of miR-200a as a novel suppressor of connexin 43 in breast cancer cells. Biosci Rep. 2015 Aug 17;35(5). pii: e00251. | ||||
REF 12 | MiR-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line HEC-1B by targeting the tumor suppressor PTEN. Mol Biol Rep. 2014;41(4):1977-84. | ||||
REF 13 | A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes. Nucleic Acids Res. 2013 Feb 1;41(4):2239-54. | ||||
REF 14 | miR-320 targets transferrin receptor 1 (CD71) and inhibits cell proliferation. Exp Hematol. 2009 Feb;37(2):245-55. | ||||
REF 15 | ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest. 2014 Jun;124(6):2696-708. | ||||
REF 16 | MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene. Transl Oncol. 2016 Feb;9(1):25-31. | ||||
REF 17 | MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer. Clin Cancer Res. 2013 Mar 15;19(6):1389-99. | ||||
REF 18 | The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 2008 May;10(5):593-601. | ||||
REF 19 | MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2. Graefes Arch Clin Exp Ophthalmol. 2012 Apr;250(4):523-31. | ||||
REF 20 | Smad3 regulates E-cadherin via miRNA-200 pathway. Oncogene. 2012 Jun 21;31(25):3051-9. | ||||
REF 21 | Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 2006 Apr 20;25(17):2537-45. | ||||
REF 22 | MicroRNA-200a-3p suppresses tumor proliferation and induces apoptosis by targeting SPAG9 in renal cell carcinoma.Biochem Biophys Res Commun. 2016 Feb 12;470(3):620-626. | ||||
REF 23 | Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.Cell. 2009 Dec 11;139(6):1096-108. | ||||
REF 24 | A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo. J Invest Dermatol. 2011 Jan;131(1):20-9. | ||||
REF 25 | The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008 Apr 1;22(7):894-907. | ||||
REF 26 | MicroRNA-200a inhibits cell growth and metastasis by targeting Foxa2 in hepatocellular carcinoma.J Cancer. 2017 Feb 25;8(4):617-625. | ||||
REF 27 | The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.Int J Oncol. 2013 Aug;43(2):548-60. | ||||
REF 28 | MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5.J Biol Chem. 2009 Jul 17;284(29):19272-9. | ||||
REF 29 | miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma.Oncol Rep. 2015 Feb;33(2):713-20. | ||||
REF 30 | microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor.BMB Rep. 2017 Apr;50(4):214-219. | ||||
REF 31 | Smad3 regulates E-cadherin via miRNA-200 pathway. Oncogene. 2012 Jun 21;31(25):3051-9. | ||||
REF 32 | Identification of microRNAs regulating Hlxb9 gene expression during the induction of insulin-producing cells.Cell Biol Int. 2016 May;40(5):515-23. | ||||
REF 33 | miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo.Oncogene. 2015 Apr 2;34(14):1790-8. | ||||
REF 34 | MicroRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB. Br J Haematol. 2017 Jan;176(1):50-64. | ||||
REF 35 | Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation.Glia. 2012 Dec;60(12):1906-14. | ||||
REF 36 | MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha.Gastroenterology. 2008 Nov;135(5):1624-1635.e24. | ||||
REF 37 | microRNA-200a inhibits cell proliferation by targeting mitochondrial transcription factor A in breast cancer.DNA Cell Biol. 2014 May;33(5):291-300. | ||||
REF 38 | Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11121-6. | ||||
REF 39 | The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion.J Biol Chem. 2009 Nov 27;284(48):33019-29. | ||||
REF 40 | The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 2008 May;10(5):593-601. |
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