miRNA General Information
miRNA Mature ID hsa-miR-18a-5p
miRNA Stemloop AC MI0000072
miRNA Stemloop ID hsa-mir-18a
Sequence uaaggugcaucuagugcagauag
TTD Target(s) Regulated by This miRNA Estrogen receptor (ESR) Successful Target Target Info [1]
Glucocorticoid receptor (NR3C1) Successful Target Target Info [2]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [3]
Osteoclast differentiation factor (ODF) Successful Target Target Info [4]
Thyroid hormone receptor alpha (THRA) Successful Target Target Info [4]
ATM serine/threonine kinase (ATM) Clinical trial Target Target Info [5]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [6]
DNA [cytosine-5]-methyltransferase 1 (DNMT1) Clinical trial Target Target Info [7]
Apoptosis mediating surface antigen FAS (FAS) Clinical trial Target Target Info [6]
Myosin light kinase (MYLK) Clinical trial Target Target Info [8]
TGF-beta receptor type II (TGFBR2) Clinical trial Target Target Info [9]
Connective tissue growth factor (CTGF) Clinical trial Target Target Info [4]
Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Target Info [5]
Immunoglobulin gamma Fc receptor IIB (FCGR2B) Clinical trial Target Target Info [10]
Thrombospondin-1 (THBS1) Clinical trial Target Target Info [11]
Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Target Info [12]
MST-1 protein kinase (STK4) Literature-reported Target Target Info [13]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [14]
Pregnane X receptor (NR1I2) Literature-reported Target Target Info [15]
Zinc finger protein A20 (TNFAIP3) Literature-reported Target Target Info [16]
Enhancer of filamentation 1 (NEDD9) Literature-reported Target Target Info [17]
Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Target Info [18]
Protein(s) Regulated by This miRNA Bcl-2-like protein 10 Regulated Protein [19]
cAMP-responsive element-binding protein-like 2 Regulated Protein [8]
Cyclin-dependent kinase 19 Regulated Protein [17]
Cyclin-L1 Regulated Protein [4]
Cysteine/serine-rich nuclear protein 3 Regulated Protein [4]
E3 SUMO-protein ligase PIAS3 Regulated Protein [23]
Exophilin-5 Regulated Protein [8]
Heat shock factor protein 2 Regulated Protein [24]
Insulin-like growth factor 2 mRNA-binding protein 2 Regulated Protein [4]
Interferon regulatory factor 2 Regulated Protein [25]
Mothers against decapentaplegic homolog 2 Regulated Protein [26]
Mothers against decapentaplegic homolog 4 Regulated Protein [27]
Myocyte-specific enhancer factor 2D Regulated Protein [28]
Neogenin Regulated Protein [29]
PH domain leucine-rich repeat-containing protein phosphatase 1 Regulated Protein [30]
Runt-related transcription factor 1 Regulated Protein [31]
Syndecan-4 Regulated Protein [32]
TATA box-binding protein-like protein 1 Regulated Protein [33]
TSC22 domain family protein 3 Regulated Protein [2]
References
REF 1 The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol. 2007 May;21(5):1132-47.
REF 2 MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain. Endocrinology. 2009 May;150(5):2220-8.
REF 3 Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia. Leukemia. 2014 Mar;28(3):554-65.
REF 4 Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 2006 Apr 20;25(17):2537-45.
REF 5 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41.
REF 6 Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences. Genes Cancer. 2014 Apr;5(1-2):56-63.
REF 7 Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med. 2013 Feb 15;187(4):397-405.
REF 8 MiR-17-92 cluster promotes hepatocarcinogenesis. Carcinogenesis. 2015 Oct;36(10):1213-22.
REF 9 miR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF- Receptor II. Mol Ther. 2017 Mar 1;25(3):728-738.
REF 10 The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop. Blood. 2013 Dec 19;122(26):4220-9.
REF 11 Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet. 2005 Dec 15;14(24):3813-21.
REF 12 The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15732-7.
REF 13 MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo. Oncogenesis. 2014 Apr 21;3:e99.
REF 14 miR-19 is a key oncogenic component of mir-17-92. Genes Dev. 2009 Dec 15;23(24):2839-49.
REF 15 Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine. Mol Pharmacol. 2017 Jul;92(1):48-56.
REF 16 Relevance of microRNA-18a and microRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation. Liver Transpl. 2016 May;22(5):665-76.
REF 17 Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. Mol Carcinog. 2013 Jun;52(6):459-74.
REF 18 Targeting of TGF signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma. RNA. 2013 Feb;19(2):177-90.
REF 19 Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions.J Allergy Clin Immunol. 2014 Apr;133(4):1065-74.
REF 20 MiR-17-92 cluster promotes hepatocarcinogenesis. Carcinogenesis. 2015 Oct;36(10):1213-22.
REF 21 Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. Mol Carcinog. 2013 Jun;52(6):459-74.
REF 22 Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 2006 Apr 20;25(17):2537-45.
REF 23 MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis.Br J Cancer. 2013 Feb 19;108(3):653-61.
REF 24 miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis.Development. 2010 Oct;137(19):3177-84.
REF 25 MicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients.J Gastroenterol Hepatol. 2016 Jan;31(1):155-63.
REF 26 Variations of microRNAs in human placentas and plasma from preeclamptic pregnancy.Hypertension. 2014 Jun;63(6):1276-84.
REF 27 The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res. 2010 Oct 15;70(20):8233-46.
REF 28 Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krpel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin.J Neurosci Res. 2015 Dec;93(12):1891-902.
REF 29 MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin.Exp Cell Res. 2014 May 15;324(1):54-64.
REF 30 The miRNA-17 2 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation.Leukemia. 2012 May;26(5):1064-72.
REF 31 MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5.Cell Signal. 2015 Jan;27(1):156-67.
REF 32 miR-18a-5p MicroRNA Increases Vascular Smooth Muscle Cell Differentiation by Downregulating Syndecan4.Korean Circ J. 2014 Jul;44(4):255-63.
REF 33 Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.Mol Med Rep. 2015 Nov;12(5):7643-8.
REF 34 MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain. Endocrinology. 2009 May;150(5):2220-8.

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