miRNA General Information
miRNA Mature ID hsa-miR-28-5p
miRNA Stemloop AC MI0000086
miRNA Stemloop ID hsa-mir-28
Sequence aaggagcucacagucuauugag
TTD Target(s) Regulated by This miRNA Thrombopoietin receptor (MPL) Successful Target Target Info [1]
Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target Target Info [1]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [2]
Insulin-like growth factor-I (IGF1) Clinical trial Target Target Info [3]
Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Target Info [4]
Protein(s) Regulated by This miRNA BAG family molecular chaperone regulator 1 Regulated Protein [5]
Interleukin-34 Regulated Protein [6]
Mitotic spindle assembly checkpoint protein MAD2A Regulated Protein [5]
NEDD4-binding protein 1 Regulated Protein [1]
Protein TEX261 Regulated Protein [1]
Ras-related protein Rap-1b Regulated Protein [5]
Ras-related protein Rap-1b Regulated Protein [8]
Signal transducer and activator of transcription 5B Regulated Protein [2]
Transcription factor E2F6 Regulated Protein [1]
Ubiquitin thioesterase OTUB1 Regulated Protein [1]
References
REF 1 miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood. 2010 Jul 22;116(3):437-45.
REF 2 Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene. 2015 Mar 5;34(10):1323-32.
REF 3 Down-regulated miR-28-5p in human hepatocellular carcinoma correlated with tumor proliferation and migration by targeting insulin-like growth factor-1 (IGF-1). Mol Cell Biochem. 2015 Oct;408(1-2):283-93.
REF 4 Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene. 2010 Apr 15;29(15):2302-8.
REF 5 MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas.Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8185-90.
REF 6 miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis.Hepatology. 2016 May;63(5):1560-75.
REF 7 miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood. 2010 Jul 22;116(3):437-45.
REF 8 miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B.Oncotarget. 2016 Nov 8;7(45):73888-73902.
REF 9 Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene. 2015 Mar 5;34(10):1323-32.

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