miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-214-3p | ||||
miRNA Stemloop AC | MI0000290 | ||||
miRNA Stemloop ID | hsa-mir-214 | ||||
Sequence | acagcaggcacagacaggcagu | ||||
TTD Target(s) Regulated by This miRNA | Fibroblast growth factor receptor 1 (FGFR1) | Successful Target | Target Info | [1] | |
Cyclin-dependent kinase 6 (CDK6) | Successful Target | Target Info | [2] | ||
Programmed cell death 1 ligand 1 (PD-L1) | Successful Target | Target Info | [3] | ||
Beta-catenin (CTNNB1) | Successful Target | Target Info | [4] | ||
Extracellular signal-regulated kinase 2 (ERK2) | Clinical trial Target | Target Info | [5] | ||
Stress-activated protein kinase 2a (p38 alpha) | Clinical trial Target | Target Info | [5] | ||
Stress-activated protein kinase JNK1 (JNK1) | Clinical trial Target | Target Info | [6] | ||
Apoptosis inhibitor survivin (BIRC5) | Clinical trial Target | Target Info | [7] | ||
Apoptosis regulator Bcl-W (BCL-W) | Clinical trial Target | Target Info | [8] | ||
Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [9] | ||
Enhancer of zeste homolog 2 (EZH2) | Successful Target | Target Info | [10] | ||
Serine/threonine-protein kinase pim-1 (PIM1) | Clinical trial Target | Target Info | [11] | ||
GTPase NRas (NRAS) | Clinical trial Target | Target Info | [12] | ||
Lactotransferrin (LTF) | Clinical trial Target | Target Info | [13] | ||
Mitochondrial matrix protein P1 (HSPD1) | Clinical trial Target | Target Info | [6] | ||
Semaphorin-4D (SEMA4D) | Clinical trial Target | Target Info | [14] | ||
T-cell-specific protein RANTES (CCL5) | Clinical trial Target | Target Info | [15] | ||
Glutathione reductase (GR) | Patented-recorded Target | Target Info | [16] | ||
Cytochrome P450 reductase (P450) | Discontinued Target | Target Info | [16] | ||
ERK activator kinase 5 (MAP2K5) | Literature-reported Target | Target Info | [6] | ||
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [17] | ||
Activating transcription factor 4 (ATF-4) | Literature-reported Target | Target Info | [18] | ||
ADP-ribosylation factor-like protein 2 (ARL2) | Literature-reported Target | Target Info | [6] | ||
Gankyrin (PSMD10) | Literature-reported Target | Target Info | [19] | ||
GTPase activating protein (RASA1) | Literature-reported Target | Target Info | [6] | ||
Hepatoma-derived growth factor (HDGF) | Literature-reported Target | Target Info | [20] | ||
Protein(s) Regulated by This miRNA | Actin-binding LIM protein 3 | Regulated Protein | [11] | ||
Alpha-protein kinase 2 | Regulated Protein | [22] | |||
Apoptosis regulator BAX | Regulated Protein | [23] | |||
Bcl-2-like protein 11 | Regulated Protein | [24] | |||
Calpain-5 | Regulated Protein | [11] | |||
Carboxypeptidase D | Regulated Protein | [25] | |||
Cell adhesion molecule 1 | Regulated Protein | [26] | |||
Cytoplasmic polyadenylation element-binding protein 4 | Regulated Protein | [11] | |||
Death-associated protein kinase 1 | Regulated Protein | [27] | |||
Dedicator of cytokinesis protein 9 | Regulated Protein | [11] | |||
Dual specificity mitogen-activated protein kinase kinase 3 | Regulated Protein | [6] | |||
Histone chaperone ASF1B | Regulated Protein | [19] | |||
Inhibitor of growth protein 4 | Regulated Protein | [30] | |||
Kinesin-like protein KIF1B | Regulated Protein | [11] | |||
Leucine zipper putative tumor suppressor 1 | Regulated Protein | [31] | |||
Myocyte-specific enhancer factor 2C | Regulated Protein | [32] | |||
N-acetylgalactosaminyltransferase 7 | Regulated Protein | [33] | |||
Pappalysin-1 | Regulated Protein | [22] | |||
Plexin-B1 | Regulated Protein | [34] | |||
POU domain, class 4, transcription factor 2 | Regulated Protein | [35] | |||
Protein jagged-1 | Regulated Protein | [36] | |||
Protein quaking | Regulated Protein | [37] | |||
Ras-related protein Rab-15 | Regulated Protein | [38] | |||
Ras-related protein Rab-5B | Regulated Protein | [11] | |||
Rho GTPase-activating protein 10 | Regulated Protein | [11] | |||
SLIT-ROBO Rho GTPase-activating protein 1 | Regulated Protein | [39] | |||
SLIT-ROBO Rho GTPase-activating protein 2 | Regulated Protein | [39] | |||
SUMO-conjugating enzyme UBC9 | Regulated Protein | [40] | |||
Suppressor of fused homolog | Regulated Protein | [41] | |||
Twinfilin-1 | Regulated Protein | [11] | |||
Twist-related protein 1 | Regulated Protein | [42] | |||
X-box-binding protein 1 | Regulated Protein | [43] | |||
Zinc finger transcription factor Trps1 | Regulated Protein | [11] | |||
References | |||||
REF 1 | Downregulation of microRNA-214 and overexpression of FGFR-1 contribute to hepatocellular carcinoma metastasis. Biochem Biophys Res Commun. 2013 Sep 13;439(1):47-53. | ||||
REF 2 | Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41. | ||||
REF 3 | Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c. Br J Cancer. 2014 Apr 15;110(8):2072-80. | ||||
REF 4 | MiR-214 targets -catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. PLoS One. 2012;7(9):e44206. | ||||
REF 5 | miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence. Br J Cancer. 2012 Oct 9;107(8):1361-73. | ||||
REF 6 | MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells. IUBMB Life. 2009 Nov;61(11):1075-82. | ||||
REF 7 | Induction of growth arrest by miR-542-3p that targets survivin. FEBS Lett. 2010 Sep 24;584(18):4048-52. | ||||
REF 8 | MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells. FEBS Lett. 2013 Mar 1;587(5):488-95. | ||||
REF 9 | miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. EMBO J. 2011 Feb 2;30(3):524-32. | ||||
REF 10 | Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol Cell. 2009 Oct 9;36(1):61-74. | ||||
REF 11 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 12 | MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesis. Oncotarget. 2014 Apr 30;5(8):2161-75. | ||||
REF 13 | miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal carcinoma. Tumour Biol. 2013 Jun;34(3):1793-800. | ||||
REF 14 | MiR-214 suppressed ovarian cancer and negatively regulated semaphorin 4D. Tumour Biol. 2016 Jun;37(6):8239-48. | ||||
REF 15 | MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov. 2012 Dec;2(12):1100-8. | ||||
REF 16 | MiR-214 promotes the alcohol-induced oxidative stress via down-regulation of glutathione reductase and cytochrome P450 oxidoreductase in liver cells. Alcohol Clin Exp Res. 2014 Jan;38(1):68-77. | ||||
REF 17 | Prediction of mammalian microRNA targets. Cell. 2003 Dec 26;115(7):787-98. | ||||
REF 18 | miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2013 Jan;19(1):93-100. | ||||
REF 19 | Restoration of microRNA-214 expression reduces growth of myeloma cells through positive regulation of P53 and inhibition of DNA replication. Haematologica. 2013 Apr;98(4):640-8. | ||||
REF 20 | MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatol. 2012 Sep;57(3):584-91. | ||||
REF 21 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 22 | miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression. Genes Chromosomes Cancer. 2013 Oct;52(10):895-911. | ||||
REF 23 | Isoflurane increases neuronal cell death vulnerability by downregulating miR-214.PLoS One. 2013;8(2):e55276. | ||||
REF 24 | Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma.PLoS One. 2014 Jan 21;9(1):e86149. | ||||
REF 25 | microRNA-214 Governs Lung Cancer Growth and Metastasis by Targeting Carboxypeptidase-D. DNA Cell Biol. 2016 Nov;35(11):715-721. | ||||
REF 26 | miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling.Genes Cells. 2013 Mar;18(3):195-202. | ||||
REF 27 | MicroRNA expression profiles in umbilical cord blood cell lineages. Stem Cells Dev. 2010 Jan;19(1):17-26. | ||||
REF 28 | MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells. IUBMB Life. 2009 Nov;61(11):1075-82. | ||||
REF 29 | Restoration of microRNA-214 expression reduces growth of myeloma cells through positive regulation of P53 and inhibition of DNA replication. Haematologica. 2013 Apr;98(4):640-8. | ||||
REF 30 | Dysregulation of miR-15a and miR-214 in human pancreatic cancer. J Hematol Oncol. 2010 Nov 24;3:46. | ||||
REF 31 | miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1.Biochem Biophys Res Commun. 2014 Jun 27;449(2):190-5. | ||||
REF 32 | Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy.Sci Rep. 2016 Oct 31;6:36146. | ||||
REF 33 | MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl--D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7.J Biol Chem. 2012 Apr 20;287(17):14301-9. | ||||
REF 34 | Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells.Int J Biochem Cell Biol. 2011 Apr;43(4):632-41. | ||||
REF 35 | Cell-specific regulation of the pro-survival Brn-3b transcription factor by microRNAs.Mol Cell Neurosci. 2010 Dec;45(4):317-23. | ||||
REF 36 | Modeling SNP mediated differential targeting of homologous 3'UTR by microRNA. RNA Biol. 2012 Mar;9(3):351-60. | ||||
REF 37 | MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release.Cardiovasc Res. 2012 Mar 15;93(4):655-65. | ||||
REF 38 | ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers.PLoS One. 2013 Dec 27;8(12):e81922. | ||||
REF 39 | MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection.Brain Res. 2011 Apr 6;1383:62-70. | ||||
REF 40 | microRNA-214-mediated UBC9 expression in glioma. BMB Rep. 2012 Nov;45(11):641-6. | ||||
REF 41 | microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu).Oncotarget. 2015 Nov 17;6(36):38705-18. | ||||
REF 42 | Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist.FEBS J. 2012 Jul;279(13):2393-8. | ||||
REF 43 | ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer.PLoS One. 2012;7(2):e31518. |
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