miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-30a-5p | ||||
miRNA Stemloop AC | MI0000088 | ||||
miRNA Stemloop ID | hsa-mir-30a | ||||
Sequence | uguaaacauccucgacuggaag | ||||
TTD Target(s) Regulated by This miRNA | Tyrosine-protein kinase ABL1 (ABL) | Successful Target | Target Info | [1] | |
Estrogen receptor beta (ESR2) | Successful Target | Target Info | [2] | ||
PI3-kinase delta (PIK3CD) | Successful Target | Target Info | [3] | ||
Tubulin beta-2 chain (TUBB2) | Successful Target | Target Info | [4] | ||
Ecto-5'-nucleotidase (CD73) | Clinical trial Target | Target Info | [5] | ||
Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [6] | ||
DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | Target Info | [7] | ||
Endoplasmic reticulum chaperone BiP (HSPA5) | Clinical trial Target | Target Info | [8] | ||
Brain-derived neurotrophic factor (BDNF) | Clinical trial Target | Target Info | [9] | ||
Interleukin 21 receptor (IL21R) | Clinical trial Target | Target Info | [10] | ||
Notch-1 receptor (NOTCH1) | Clinical trial Target | Target Info | [11] | ||
Integrin beta-3 (ITGB3) | Literature-reported Target | Target Info | [12] | ||
Lysyl oxidase (LOX) | Literature-reported Target | Target Info | [13] | ||
Beclin-1 (BECN1) | Literature-reported Target | Target Info | [14] | ||
Epithelial cadherin (CDH1) | Literature-reported Target | Target Info | [15] | ||
Metastasis adhesion protein (MTDH) | Literature-reported Target | Target Info | [5] | ||
Muscleblind-like protein 1 (MBNL2) | Literature-reported Target | Target Info | [16] | ||
S-phase kinase-associated protein 2 (SKP2) | Literature-reported Target | Target Info | [17] | ||
G1/S-specific cyclin-E2 (CCNE2) | Literature-reported Target | Target Info | [18] | ||
Runt-related transcription factor 2 (RUNX2) | Literature-reported Target | Target Info | [19] | ||
Protein(s) Regulated by This miRNA | Adapter protein CIKS | Regulated Protein | [20] | ||
B-cell CLL/lymphoma 9 protein | Regulated Protein | [21] | |||
B-cell lymphoma/leukemia 11A | Regulated Protein | [22] | |||
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like | Regulated Protein | [23] | |||
CD99 antigen | Regulated Protein | [24] | |||
Cell death regulator Aven | Regulated Protein | [25] | |||
Chromobox protein homolog 3 | Regulated Protein | [26] | |||
Cyclic AMP-dependent transcription factor ATF-1 | Regulated Protein | [27] | |||
Denticleless protein homolog | Regulated Protein | [28] | |||
E3 ubiquitin-protein ligase NEDD4-like | Regulated Protein | [17] | |||
Eyes absent homolog 2 | Regulated Protein | [30] | |||
Forkhead box protein D1 | Regulated Protein | [25] | |||
Forkhead box protein L2 | Regulated Protein | [31] | |||
Hepatocyte nuclear factor 4-gamma | Regulated Protein | [32] | |||
Krueppel-like factor 9 | Regulated Protein | [17] | |||
Methylcytosine dioxygenase TET1 | Regulated Protein | [33] | |||
Muscleblind-like protein 1 | Regulated Protein | [16] | |||
Muscleblind-like protein 3 | Regulated Protein | [16] | |||
Neural cell adhesion molecule 1 | Regulated Protein | [35] | |||
Neurogenic differentiation factor 1 | Regulated Protein | [4] | |||
Perilipin-2 | Regulated Protein | [37] | |||
Phosphatidylinositol 3-kinase regulatory subunit beta | Regulated Protein | [38] | |||
PR domain zinc finger protein 1 | Regulated Protein | [39] | |||
Proline-rich transmembrane protein 2 | Regulated Protein | [40] | |||
Ras-related protein Rab-38 | Regulated Protein | [17] | |||
Replication protein A 70 kDa DNA-binding subunit | Regulated Protein | [41] | |||
Septin-7 | Regulated Protein | [42] | |||
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | Regulated Protein | [18] | |||
Transcription factor SOX-4 | Regulated Protein | [44] | |||
Transcriptional regulator ERG | Regulated Protein | [45] | |||
Trinucleotide repeat-containing gene 6A protein | Regulated Protein | [46] | |||
Ubiquitin-protein ligase E3C | Regulated Protein | [47] | |||
Vimentin | Regulated Protein | [48] | |||
Zinc finger protein SNAI1 | Regulated Protein | [49] | |||
References | |||||
REF 1 | Decreased microRNA-30a levels are associated with enhanced ABL1 and BCR-ABL1 expression in chronic myeloid leukemia. Leuk Res. 2013 Mar;37(3):349-56. | ||||
REF 2 | Post-transcriptional regulation of human breast cancer cell proteome by unliganded estrogen receptor via microRNAs. Mol Cell Proteomics. 2014 Apr;13(4):1076-90. | ||||
REF 3 | miR-30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma. Cell Physiol Biochem. 2013;31(2-3):209-18. | ||||
REF 4 | miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models. Diabetologia. 2013 Apr;56(4):847-55. | ||||
REF 5 | Widespread changes in protein synthesis induced by microRNAs.Nature. 2008 Sep 4;455(7209):58-63. | ||||
REF 6 | Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids. J Am Soc Nephrol. 2014 Jan;25(1):92-104. | ||||
REF 7 | A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells. Cell Physiol Biochem. 2017;41(3):973-986. | ||||
REF 8 | Downregulation of the miR-30 family microRNAs contributes to endoplasmic reticulum stress in cardiac muscle and vascular smooth muscle cells. Int J Cardiol. 2014 Apr 15;173(1):65-73. | ||||
REF 9 | A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet. 2008 Oct 1;17(19):3030-42. | ||||
REF 10 | EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 May 2;31(9):2207-21. | ||||
REF 11 | Exploration of human miRNA target genes in neuronal differentiation. Nucleic Acids Symp Ser (Oxf). 2005;(49):341-2. | ||||
REF 12 | MiR-30a-5p Suppresses Tumor Metastasis of Human Colorectal Cancer by Targeting ITGB3. Cell Physiol Biochem. 2016;39(3):1165-76. | ||||
REF 13 | miR30a inhibits LOX expression and anaplastic thyroid cancer progression. Cancer Res. 2015 Jan 15;75(2):367-77. | ||||
REF 14 | Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy. 2009 Aug;5(6):816-23. | ||||
REF 15 | MicroRNA-30a promotes invasiveness and metastasis initro and inivo through epithelial-mesenchymal transition and results in poor survival of na... Exp Biol Med (Maywood). 2014 Jul;239(7):891-898. | ||||
REF 16 | miR-30-5p Regulates Muscle Differentiation and Alternative Splicing of Muscle-Related Genes by Targeting MBNL. Int J Mol Sci. 2016 Jan 29;17(2). pii: E182. | ||||
REF 17 | The miR-30 Family Inhibits Pulmonary Vascular Hyperpermeability in the Premetastatic Phase by Direct Targeting of Skp2. Clin Cancer Res. 2015 Jul 1;21(13):3071-80. | ||||
REF 18 | MiR-30a attenuates immunosuppressive functions of IL-1-elicited mesenchymal stem cells via targeting TAB3. FEBS Lett. 2015 Dec 21;589(24 Pt B):3899-907. | ||||
REF 19 | Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol. 2011 Jul 18;12(7):R64. | ||||
REF 20 | The miR-30a Negatively Regulates IL-17-Mediated Signal Transduction by Targeting Traf3ip2.J Interferon Cytokine Res. 2015 Nov;35(11):917-23. | ||||
REF 21 | miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/-catenin/BCL9 pathway.Cancer Res. 2014 Mar 15;74(6):1801-13. | ||||
REF 22 | BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification.Mol Cancer. 2013 Jun 12;12:61. | ||||
REF 23 | Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma. Mol Cancer. 2015 Oct 15;14:181. | ||||
REF 24 | MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor.Oncogene. 2013 Aug 15;32(33):3915-21. | ||||
REF 25 | MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells.BMC Genomics. 2013 Feb 28;14:139. | ||||
REF 26 | Heterochromatin protein HP1 promotes colorectal cancer progression and is regulated by miR-30a.Cancer Res. 2015 Nov 1;75(21):4593-604. | ||||
REF 27 | miR-30a radiosensitizes non-small cell lung cancer by targeting ATF1 that is involved in the phosphorylation of ATM.Oncol Rep. 2017 Apr;37(4):1980-1988. | ||||
REF 28 | MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL.Carcinogenesis. 2012 Apr;33(4):732-9. | ||||
REF 29 | The miR-30 Family Inhibits Pulmonary Vascular Hyperpermeability in the Premetastatic Phase by Direct Targeting of Skp2. Clin Cancer Res. 2015 Jul 1;21(13):3071-80. | ||||
REF 30 | miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2.Biochem Biophys Res Commun. 2014 Mar 7;445(2):314-9. | ||||
REF 31 | MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2. Oncol Lett. 2015 Feb;9(2):967-971. | ||||
REF 32 | miR-30-HNF4 and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach.Gut. 2016 Jun;65(6):914-24. | ||||
REF 33 | miR-30a as Potential Therapeutics by Targeting TET1 through Regulation of Drp-1 Promoter Hydroxymethylation in Idiopathic Pulmonary Fibrosis.Int J Mol Sci. 2017 Mar 15;18(3). pii: E633. | ||||
REF 34 | miR-30-5p Regulates Muscle Differentiation and Alternative Splicing of Muscle-Related Genes by Targeting MBNL. Int J Mol Sci. 2016 Jan 29;17(2). pii: E182. | ||||
REF 35 | MiR-30a-5p is induced by Wnt/-catenin pathway and promotes glioma cell invasion by repressing NCAM.Biochem Biophys Res Commun. 2015 Sep 25;465(3):374-80. | ||||
REF 36 | miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models. Diabetologia. 2013 Apr;56(4):847-55. | ||||
REF 37 | miR-148a and miR-30a limit HCV-dependent suppression of the lipid droplet protein, ADRP, in HCV infected cell models.J Med Virol. 2017 Apr;89(4):653-659. | ||||
REF 38 | MiR-30a-5p Overexpression May Overcome EGFR-Inhibitor Resistance through Regulating PI3K/AKT Signaling Pathway in Non-small Cell Lung Cancer Cell L... Front Genet. 2016 Nov 15;7:197. | ||||
REF 39 | PRDM1 is directly targeted by miR-30a-5p and modulates the Wnt/-catenin pathway in a Dkk1-dependent manner during glioma growth.Cancer Lett. 2013 May 1;331(2):211-9. | ||||
REF 40 | PRRT2 inhibits the proliferation of glioma cells by modulating unfolded protein response pathway.Biochem Biophys Res Commun. 2017 Apr 1;485(2):454-460. | ||||
REF 41 | miR-30a can inhibit DNA replication by targeting RPA1 thus slowing cancer cell proliferation.Biochem J. 2016 Jul 15;473(14):2131-9. | ||||
REF 42 | MiR-30a-5p antisense oligonucleotide suppresses glioma cell growth by targeting SEPT7.PLoS One. 2013;8(1):e55008. | ||||
REF 43 | MiR-30a attenuates immunosuppressive functions of IL-1-elicited mesenchymal stem cells via targeting TAB3. FEBS Lett. 2015 Dec 21;589(24 Pt B):3899-907. | ||||
REF 44 | Metformin inhibits epithelial-mesenchymal transition in prostate cancer cells: involvement of the tumor suppressor miR30a and its target gene SOX4.Biochem Biophys Res Commun. 2014 Sep 26;452(3):746-52. | ||||
REF 45 | miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT.Oncogene. 2014 May 8;33(19):2495-503. | ||||
REF 46 | Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets.Genome Res. 2009 Nov;19(11):2009-20. | ||||
REF 47 | MiR-30a-5p/UBE3C axis regulates breast cancer cell proliferation and migration. Biochem Biophys Res Commun. 2016 Mar 18. pii: S0006-291X(16)30381-3. | ||||
REF 48 | RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric cancer cells.J Cell Mol Med. 2014 Apr;18(4):610-23. | ||||
REF 49 | MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer.Int J Cancer. 2012 May 1;130(9):2044-53. |
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