miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-27a-3p | ||||
miRNA Stemloop AC | MI0000085 | ||||
miRNA Stemloop ID | hsa-mir-27a | ||||
Sequence | uucacaguggcuaaguuccgc | ||||
TTD Target(s) Regulated by This miRNA | Epidermal growth factor receptor (EGFR) | Successful Target | Target Info | [1] | |
HMG-CoA reductase (HMGCR) | Successful Target | Target Info | [2] | ||
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Successful Target | Target Info | [3] | ||
PI3-kinase gamma (PIK3CG) | Successful Target | Target Info | [4] | ||
Proto-oncogene c-Met (MET) | Successful Target | Target Info | [5] | ||
ATP-binding cassette transporter A1 (ABCA1) | Successful Target | Target Info | [6] | ||
Interferon-gamma (IFNG) | Successful Target | Target Info | [7] | ||
Low-density lipoprotein receptor (LDL-R) | Successful Target | Target Info | [8] | ||
Retinoic acid receptor RXR-alpha (RXRA) | Successful Target | Target Info | [9] | ||
Thyroid hormone receptor beta (THRB) | Successful Target | Target Info | [10] | ||
Dihydrothymine dehydrogenase (DPYD) | Successful Target | Target Info | [11] | ||
Glycogen synthase kinase-3 beta (GSK-3B) | Clinical trial Target | Target Info | [12] | ||
Matrix metalloproteinase-13 (MMP-13) | Clinical trial Target | Target Info | [13] | ||
Retinoic acid receptor alpha (RARA) | Clinical trial Target | Target Info | [9] | ||
Stress-activated protein kinase 2a (p38 alpha) | Clinical trial Target | Target Info | [14] | ||
Wee1-like protein kinase (WEE1) | Clinical trial Target | Target Info | [15] | ||
Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [16] | ||
Enhancer of zeste homolog 2 (EZH2) | Successful Target | Target Info | [17] | ||
G1/S-specific cyclin-D1 (CCND1) | Clinical trial Target | Target Info | [18] | ||
Nuclear factor erythroid 2-related factor 2 (Nrf2) | Successful Target | Target Info | [19] | ||
Hypoxia-inducible factor 1 alpha (HIF-1A) | Clinical trial Target | Target Info | [20] | ||
Tissue factor pathway inhibitor (TFPI) | Clinical trial Target | Target Info | [21] | ||
Insulin-like growth factor-I (IGF1) | Clinical trial Target | Target Info | [22] | ||
Transcription factor Sp1 (SP1) | Clinical trial Target | Target Info | [23] | ||
Forkhead box protein O1A (FOXO1) | Literature-reported Target | Target Info | [24] | ||
GATA-binding factor 3 (GATA3) | Literature-reported Target | Target Info | [25] | ||
Homeodomain interacting protein kinase 2 (HIPK2) | Literature-reported Target | Target Info | [26] | ||
Mannose receptor (MRC1) | Literature-reported Target | Target Info | [27] | ||
Cystine/glutamate transporter (SLC7A11) | Clinical trial Target | Target Info | [28] | ||
Dickkopf-related protein 2 (DKK2) | Literature-reported Target | Target Info | [29] | ||
F-box and WD-40 domain protein 7 (Fbxw7) | Literature-reported Target | Target Info | [30] | ||
Prohibitin (PHB) | Literature-reported Target | Target Info | [31] | ||
Yes-associated protein 1 (YAP1) | Literature-reported Target | Target Info | [32] | ||
Protein(s) Regulated by This miRNA | 14-3-3 protein zeta/delta | Regulated Protein | [33] | ||
5'-AMP-activated protein kinase catalytic subunit alpha-2 | Regulated Protein | [34] | |||
Adenomatous polyposis coli protein | Regulated Protein | [35] | |||
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Regulated Protein | [36] | |||
Calcium-binding protein 39-like | Regulated Protein | [36] | |||
Calponin-3 | Regulated Protein | [36] | |||
Cell division cycle protein 27 homolog | Regulated Protein | [37] | |||
Cyclin-Y-like protein 1 | Regulated Protein | [36] | |||
Cysteine-rich secretory protein 2 | Regulated Protein | [36] | |||
Dual specificity mitogen-activated protein kinase kinase 4 | Regulated Protein | [38] | |||
E3 ubiquitin-protein transferase RMND5A | Regulated Protein | [36] | |||
Endothelial transcription factor GATA-2 | Regulated Protein | [39] | |||
Follistatin-related protein 1 | Regulated Protein | [40] | |||
Homeobox protein Hox-A10 | Regulated Protein | [41] | |||
Interferon alpha/beta receptor 1 | Regulated Protein | [42] | |||
Lysosome-associated membrane glycoprotein 2 | Regulated Protein | [43] | |||
Methylosome protein 50 | Regulated Protein | [44] | |||
Mothers against decapentaplegic homolog 2 | Regulated Protein | [45] | |||
Mothers against decapentaplegic homolog 4 | Regulated Protein | [46] | |||
Mothers against decapentaplegic homolog 5 | Regulated Protein | [47] | |||
Myelin transcription factor 1 | Regulated Protein | [23] | |||
Paired box protein Pax-3 | Regulated Protein | [49] | |||
PH domain leucine-rich repeat-containing protein phosphatase 2 | Regulated Protein | [50] | |||
Phosphatidate phosphatase LPIN1 | Regulated Protein | [36] | |||
Poly(U)-specific endoribonuclease | Regulated Protein | [36] | |||
Prosaposin | Regulated Protein | [51] | |||
Protein BTG2 | Regulated Protein | [52] | |||
Protein BTG2 | Regulated Protein | [53] | |||
Protein sprouty homolog 2 | Regulated Protein | [54] | |||
Secreted frizzled-related protein 1 | Regulated Protein | [55] | |||
Secreted frizzled-related protein 1 | Regulated Protein | [56] | |||
Semaphorin-6A | Regulated Protein | [57] | |||
Semaphorin-7A | Regulated Protein | [7] | |||
Serine/threonine-protein kinase PINK1, mitochondrial | Regulated Protein | [59] | |||
Serine/threonine-protein kinase WNK1 | Regulated Protein | [36] | |||
Serine/threonine-protein phosphatase CPPED1 | Regulated Protein | [36] | |||
Sialoadhesin | Regulated Protein | [60] | |||
Sister chromatid cohesion protein PDS5 homolog B | Regulated Protein | [61] | |||
Sodium- and chloride-dependent creatine transporter 1 | Regulated Protein | [62] | |||
TBC1 domain family member 9 | Regulated Protein | [63] | |||
Transcription factor Sp3 | Regulated Protein | [23] | |||
Transcription factor Sp4 | Regulated Protein | [23] | |||
Zinc finger and BTB domain-containing protein 10 | Regulated Protein | [23] | |||
Zinc finger protein PLAG1 | Regulated Protein | [64] | |||
Zinc finger protein RFP | Regulated Protein | [60] | |||
References | |||||
REF 1 | Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression. Cell Death Dis. 2013 Apr 4;4:e574. | ||||
REF 2 | Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. MBio. 2015 Dec 8;6(6):e01500-15. | ||||
REF 3 | Hypoxia mediates mutual repression between microRNA-27a and PPAR in the pulmonary vasculature. PLoS One. 2013 Nov 14;8(11):e79503. | ||||
REF 4 | MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K. PLoS One. 2013 Sep 25;8(9):e75251. | ||||
REF 5 | Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8573-8. | ||||
REF 6 | MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages. Atherosclerosis. 2014 May;234(1):54-64. | ||||
REF 7 | Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function. Mol Cell. 2014 Apr 10;54(1):67-79. | ||||
REF 8 | Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell. 2013 Jan 17;152(1-2):82-96. | ||||
REF 9 | MicroRNA-27a Contributes to Rhabdomyosarcoma Cell Proliferation by Suppressing RARA and RXRA. PLoS One. 2015 Apr 27;10(4):e0125171. | ||||
REF 10 | MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes. Mol Cell Biol. 2011 Feb;31(4):744-55. | ||||
REF 11 | microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Mol Cancer Ther. 2014 Mar;13(3):742-51. | ||||
REF 12 | Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3-involved Wnt/-catenin pathway. Oncotarget. 2017 Feb 28;8(9):14708-14718. | ||||
REF 13 | Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord. 2009 Nov 30;10:148. | ||||
REF 14 | Regulation of Insulin Resistance by Multiple MiRNAs via Targeting the GLUT4 Signalling Pathway. Cell Physiol Biochem. 2016;38(5):2063-78. | ||||
REF 15 | Prediction of Associations between microRNAs and Gene Expression in Glioma Biology. PLoS One. 2011 Feb 16;6(2):e14681. | ||||
REF 16 | Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell. 2010 Jun 11;38(5):689-99. | ||||
REF 17 | Analysis of EZH2: micro-RNA network in low and high grade astrocytic tumors. Brain Tumor Pathol. 2016 Apr;33(2):117-28. | ||||
REF 18 | Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells. J Exp Clin Cancer Res. 2011 May 13;30:55. | ||||
REF 19 | Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells. PLoS One. 2012;7(12):e51111. | ||||
REF 20 | HIF-1 Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a. PLoS One. 2015 Aug 20;10(8):e0132746. | ||||
REF 21 | The role of microRNA-27a/b and microRNA-494 in estrogen-mediated downregulation of tissue factor pathway inhibitor . J Thromb Haemost. 2016 Jun;14(6):1226-37. | ||||
REF 22 | A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs. Oncogene. 2011 Dec 8;30(49):4910-20. | ||||
REF 23 | The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res. 2007 Nov 15;67(22):11001-11. | ||||
REF 24 | Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem. 2009 Aug 28;284(35):23204-16. | ||||
REF 25 | miR-23 7 4 clusters control effector T cell differentiation and function. J Exp Med. 2016 Feb 8;213(2):235-49. | ||||
REF 26 | MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells. Gynecol Oncol. 2010 Oct;119(1):125-30. | ||||
REF 27 | MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages. J Biol Chem. 2016 Jan 1;291(1):149-59. | ||||
REF 28 | Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11. Clin Cancer Res. 2014 Apr 1;20(7):1990-2000. | ||||
REF 29 | The transcription factor ccaat/enhancer binding protein (C/EBP) and miR-27a regulate the expression of porcine Dickkopf2 (DKK2). Sci Rep. 2015 Dec 11;5:17972. | ||||
REF 30 | Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41. | ||||
REF 31 | MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. Cancer Lett. 2009 Jan 18;273(2):233-42. | ||||
REF 32 | MicroRNA-27a-3p regulates epithelial to mesenchymal transition via targeting YAP1 in oral squamous cell carcinoma cells. Oncol Rep. 2016 Sep;36(3):1475-82. | ||||
REF 33 | MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3.PLoS One. 2012;7(12):e50895. | ||||
REF 34 | miR-27a-mediated antiproliferative effects of metformin on the breast cancer cell line MCF-7.Oncol Rep. 2016 Dec;36(6):3691-3699. | ||||
REF 35 | miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition.Cancer Genet. 2011 Sep;204(9):486-91. | ||||
REF 36 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 37 | MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.Med Sci Monit. 2015 May 6;21:1297-303. | ||||
REF 38 | MicroRNA-27a promotes proliferation, migration and invasion by targeting MAP2K4 in human osteosarcoma cells.Cell Physiol Biochem. 2014;33(2):402-12. | ||||
REF 39 | SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.J Biol Chem. 2013 Feb 22;288(8):5381-8. | ||||
REF 40 | MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis.Mol Cells. 2016 Aug 31;39(8):611-8. | ||||
REF 41 | Genetic variations in miR-27a gene decrease mature miR-27a level and reduce gastric cancer susceptibility.Oncogene. 2014 Jan 9;33(2):193-202. | ||||
REF 42 | The TGF--inducible miR-23a cluster attenuates IFN- levels and antigen-specific cytotoxicity in human CD8 T cells. J Leukoc Biol. 2014 Oct;96(4):633-45. | ||||
REF 43 | MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion.Mol Neurobiol. 2017 May;54(4):2595-2610. | ||||
REF 44 | MicroRNA-27a regulates basal transcription by targeting the p44 subunit of general transcription factor IIH.Proc Natl Acad Sci U S A. 2011 May 24;108(21):8686-91. | ||||
REF 45 | MIR-27a regulates the TGF- signaling pathway by targeting SMAD2 and SMAD4 in lung cancer.Mol Carcinog. 2017 Aug;56(8):1992-1998. | ||||
REF 46 | MicroRNA-27a-3p Is a Negative Regulator of Lung Fibrosis by Targeting Myofibroblast Differentiation.Am J Respir Cell Mol Biol. 2016 Jun;54(6):843-52. | ||||
REF 47 | miR-23a and miR-27a promote human granulosa cell apoptosis by targeting SMAD5.Biol Reprod. 2015 Oct;93(4):98. | ||||
REF 48 | The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res. 2007 Nov 15;67(22):11001-11. | ||||
REF 49 | Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression.Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13383-7. | ||||
REF 50 | MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2.J Exp Clin Cancer Res. 2017 Mar 21;36(1):45. | ||||
REF 51 | The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin.J Biol Chem. 2014 Aug 8;289(32):21888-95. | ||||
REF 52 | miR 7a suppresses the clonogenic growth and migration of human glioblastoma multiforme cells by targeting BTG2.Int J Oncol. 2015 Apr;46(4):1601-8. | ||||
REF 53 | MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2.Oncotarget. 2016 Aug 9;7(32):51943-51954. | ||||
REF 54 | miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2.Cancer Lett. 2010 Dec 8;298(2):150-8. | ||||
REF 55 | In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/-catenin signaling pathway.Oncotarget. 2017 Feb 28;8(9):15507-15519. | ||||
REF 56 | MiRNA-27a promotes the proliferation and invasion of human gastric cancer MGC803 cells by targeting SFRP1 via Wnt/-catenin signaling pathway. Am J Cancer Res. 2017 Mar 1;7(3):405-416. | ||||
REF 57 | MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A.Blood. 2012 Feb 9;119(6):1607-16. | ||||
REF 58 | Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function. Mol Cell. 2014 Apr 10;54(1):67-79. | ||||
REF 59 | miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).Mol Neurodegener. 2016 Jul 26;11(1):55. | ||||
REF 60 | Type I IFN-Inducible Downregulation of MicroRNA-27a Feedback Inhibits Antiviral Innate Response by Upregulating Siglec1/TRIM27.J Immunol. 2016 Feb 1;196(3):1317-26. | ||||
REF 61 | Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer. PLoS One. 2013;8(2):e56592. | ||||
REF 62 | Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer.Cell Death Dis. 2016 Feb 25;7:e2120. | ||||
REF 63 | Role of miR-27a, miR-181a and miR-20b in gastric cancer hypoxia-induced chemoresistance. Cancer Biol Ther. 2016 Apr 2;17(4):400-6. | ||||
REF 64 | MiR-424 and miR-27a increase TRAIL sensitivity of acute myeloid leukemia by targeting PLAG1.Oncotarget. 2016 May 3;7(18):25276-90. |
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