Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Target Poor or Non Binders
Target Regulators
References
Drug Binding Sites of Target  Top
Ligand Name: Alpha-D-Mannose Ligand Info
Structure Description C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Man-alpha1-6Man PDB:7JUG
Method X-ray diffraction Resolution 1.40 Å Mutation No [2]
PDB Sequence
ACPEDWGASS
636
RTSLCFKLYA
646
KGKHEKKTWF
656
ESRDFCRALG
666
GDLASINNKE
676

EQQTIWRLIT
686
ASGSYHKLFW
696
LGLTYGSPSE
706
GFTWSDGSPV
716
SYENWAYGEP
726

NNYQNVEYCG
736
ELKGDPTMSW
746
NDINCEHLNN
756
WICQI
Residue
Distance (Å)
GLU725
2.545
ASN727
2.813
TYR729
4.139
GLU733
2.613
Residue
Distance (Å)
ASN747
3.048
ASP748
2.970
ILE749
3.543
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: Methyl alpha-D-mannopyranoside Ligand Info
Structure Description C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside PDB:7JUB
Method X-ray diffraction Resolution 1.20 Å Mutation No [2]
PDB Sequence
LCFKLYAKGK
649
HEKKTWFESR
659
DFCRALGGDL
669
ASINNKEEQQ
679
TIWRLITASG
689

SYHKLFWLGL
699
TYGSPSEGFT
709
WSDGSPVSYE
719
NWAYGEPNNY
729
QNVEYCGELK
739

GDPTMSWNDI
749
NCEHLNNWIC
759
QI
Residue
Distance (Å)
GLU725
2.563
ASN727
2.877
TYR729
3.717
GLU733
2.561
Residue
Distance (Å)
GLU737
4.290
ASN747
2.988
ASP748
2.868
ILE749
3.503
Click to View More Binding Site Information of This Target and Ligand Pair
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Human Similarity Proteins
Human Pathway Affiliation
There is no similarity protein (E value < 0.005) for this target
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Phagosome hsa04145 Affiliated Target
  Class: Cellular Processes => Transport and catabolism Pathway Hierarchy

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