Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T93278 Target Info
Target Name Mannose receptor (MRC1)
Synonyms Macrophage mannose receptor 1like protein 1; Macrophage mannose receptor 1-like protein 1; Macrophage mannose receptor 1; MRC1L1; MMR; Human mannose receptor; Ctype lectin domain family 13 member Dlike; Ctype lectin domain family 13 member D; CLEC13DL; CLEC13D; CD206; C-type lectin domain family 13 member D-like; C-type lectin domain family 13 member D
Target Type Literature-reported Target
Gene Name MRC1
Biochemical Class Fibronectin protein
UniProt ID
MRC1_HUMAN
Ligand General Information  Top
Ligand Name Alpha-D-Mannose Ligand Info
Canonical SMILES C(C1C(C(C(C(O1)O)O)O)O)O
InChI 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKey WQZGKKKJIJFFOK-PQMKYFCFSA-N
PubChem Compound ID 185698
Drug Binding Sites of Target  Top
PDB ID: 7JUG      C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Man-alpha1-6Man
Method X-ray diffraction Resolution 1.40 Å Mutation No [1]
PDB Sequence
ACPEDWGASS
636
RTSLCFKLYA
646
KGKHEKKTWF
656
ESRDFCRALG
666
GDLASINNKE
676

EQQTIWRLIT
686
ASGSYHKLFW
696
LGLTYGSPSE
706
GFTWSDGSPV
716
SYENWAYGEP
726

NNYQNVEYCG
736
ELKGDPTMSW
746
NDINCEHLNN
756
WICQI
Residue
Distance (Å)
GLU725
2.545
ASN727
2.813
TYR729
4.139
GLU733
2.613
Residue
Distance (Å)
ASN747
3.048
ASP748
2.970
ILE749
3.543
PDB ID: 7JUH      C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Man-alpha1-6Man
Method X-ray diffraction Resolution 1.40 Å Mutation No [1]
PDB Sequence
SLCFKLYAKG
648
KHEKKTWFES
658
RDFCRALGGD
668
LASINNKEEQ
678
QTIWRLITAS
688

GSYHKLFWLG
698
LTYGSPSEGF
708
TWSDGSPVSY
718
ENWAYGEPNN
728
YQNVEYCGEL
738

KGDPTMSWND
748
INCEHLNNWI
758
CQI
Residue
Distance (Å)
GLU725
2.536
ASN727
3.006
TYR729
4.225
GLU733
2.565
Residue
Distance (Å)
ASN747
3.068
ASP748
2.979
ILE749
4.251
HIS753
4.558
References  Top
REF 1 Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J Biol Chem. 2021 Jan-Jun;296:100368.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.