Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93278 | Target Info | |||
| Target Name | Mannose receptor (MRC1) | ||||
| Synonyms | Macrophage mannose receptor 1like protein 1; Macrophage mannose receptor 1-like protein 1; Macrophage mannose receptor 1; MRC1L1; MMR; Human mannose receptor; Ctype lectin domain family 13 member Dlike; Ctype lectin domain family 13 member D; CLEC13DL; CLEC13D; CD206; C-type lectin domain family 13 member D-like; C-type lectin domain family 13 member D | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MRC1 | ||||
| Biochemical Class | Fibronectin protein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Alpha-D-Mannose | Ligand Info | |||||
| Structure Description | C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Man-alpha1-6Man | PDB:7JUG | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [1] |
| PDB Sequence |
ACPEDWGASS
636 RTSLCFKLYA646 KGKHEKKTWF656 ESRDFCRALG666 GDLASINNKE676 EQQTIWRLIT 686 ASGSYHKLFW696 LGLTYGSPSE706 GFTWSDGSPV716 SYENWAYGEP726 NNYQNVEYCG 736 ELKGDPTMSW746 NDINCEHLNN756 WICQI
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Methyl alpha-D-mannopyranoside | Ligand Info | |||||
| Structure Description | C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside | PDB:7JUB | ||||
| Method | X-ray diffraction | Resolution | 1.20 Å | Mutation | No | [1] |
| PDB Sequence |
LCFKLYAKGK
649 HEKKTWFESR659 DFCRALGGDL669 ASINNKEEQQ679 TIWRLITASG689 SYHKLFWLGL 699 TYGSPSEGFT709 WSDGSPVSYE719 NWAYGEPNNY729 QNVEYCGELK739 GDPTMSWNDI 749 NCEHLNNWIC759 QI
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Methyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside | Ligand Info | |||||
| Structure Description | C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Methyl-GlcNAc | PDB:7L65 | ||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [1] |
| PDB Sequence |
LCFKLYAKGK
649 HEKKTWFESR659 DFCRALGGDL669 ASINNKEEQQ679 TIWRLITASG689 SYHKLFWLGL 699 TYGSPSEGFT709 WSDGSPVSYE719 NWAYGEPNNY729 QNVEYCGELK739 GDPTMSWNDI 749 NCEHLNNWIC759 QI
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Click to Show 3D Structure of This Binding Site
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
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| REF 1 | Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J Biol Chem. 2021 Jan-Jun;296:100368. | ||||
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