Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T93278 Target Info
Target Name Mannose receptor (MRC1)
Synonyms Macrophage mannose receptor 1like protein 1; Macrophage mannose receptor 1-like protein 1; Macrophage mannose receptor 1; MRC1L1; MMR; Human mannose receptor; Ctype lectin domain family 13 member Dlike; Ctype lectin domain family 13 member D; CLEC13DL; CLEC13D; CD206; C-type lectin domain family 13 member D-like; C-type lectin domain family 13 member D
Target Type Literature-reported Target
Gene Name MRC1
Biochemical Class Fibronectin protein
UniProt ID
MRC1_HUMAN
Ligand General Information  Top
Ligand Name Methyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside Ligand Info
Canonical SMILES CC(=O)NC1C(C(C(OC1OC)CO)O)O
InChI 1S/C9H17NO6/c1-4(12)10-6-8(14)7(13)5(3-11)16-9(6)15-2/h5-9,11,13-14H,3H2,1-2H3,(H,10,12)/t5-,6-,7-,8-,9+/m1/s1
InChIKey ZEVOCXOZYFLVKN-OKNNCHMLSA-N
PubChem Compound ID 96523
Drug Binding Sites of Target  Top
PDB ID: 7L65      C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Methyl-GlcNAc
Method X-ray diffraction Resolution 1.35 Å Mutation No [1]
PDB Sequence
LCFKLYAKGK
649
HEKKTWFESR
659
DFCRALGGDL
669
ASINNKEEQQ
679
TIWRLITASG
689

SYHKLFWLGL
699
TYGSPSEGFT
709
WSDGSPVSYE
719
NWAYGEPNNY
729
QNVEYCGELK
739

GDPTMSWNDI
749
NCEHLNNWIC
759
QI
Residue
Distance (Å)
GLU725
2.541
ASN727
2.888
TYR729
3.796
GLU733
2.567
GLU737
4.842
Residue
Distance (Å)
ASN747
3.055
ASP748
2.923
ILE749
3.767
HIS753
4.373
PDB ID: 7L66      C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Methyl-GlcNAc
Method X-ray diffraction Resolution 1.75 Å Mutation No [1]
PDB Sequence
CPLCFKLYAK
647
GKHEKKTWFE
657
SRDFCRALGG
667
DLASINNKEE
677
QQTIWRLITA
687

SGSYHKLFWL
697
GLTYGSPSEG
707
FTWSDGSPVS
717
YENWAYGEPN
727
NYQNVEYCGE
737

LKGDPTMSWN
747
DINCEHLNNW
757
ICQI
Residue
Distance (Å)
GLU725
2.572
ASN727
2.935
TYR729
3.865
GLU733
2.526
Residue
Distance (Å)
ASN747
2.992
ASP748
2.906
ILE749
3.947
References  Top
REF 1 Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J Biol Chem. 2021 Jan-Jun;296:100368.

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