Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T93278 | Target Info | |||
Target Name | Mannose receptor (MRC1) | ||||
Synonyms | Macrophage mannose receptor 1like protein 1; Macrophage mannose receptor 1-like protein 1; Macrophage mannose receptor 1; MRC1L1; MMR; Human mannose receptor; Ctype lectin domain family 13 member Dlike; Ctype lectin domain family 13 member D; CLEC13DL; CLEC13D; CD206; C-type lectin domain family 13 member D-like; C-type lectin domain family 13 member D | ||||
Target Type | Literature-reported Target | ||||
Gene Name | MRC1 | ||||
Biochemical Class | Fibronectin protein | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | Methyl alpha-D-mannopyranoside | Ligand Info | |||
Canonical SMILES | COC1C(C(C(C(O1)CO)O)O)O | ||||
InChI | 1S/C7H14O6/c1-12-7-6(11)5(10)4(9)3(2-8)13-7/h3-11H,2H2,1H3/t3-,4-,5+,6+,7+/m1/s1 | ||||
InChIKey | HOVAGTYPODGVJG-VEIUFWFVSA-N | ||||
PubChem Compound ID | 101798 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 7JUB C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside | ||||||
Method | X-ray diffraction | Resolution | 1.20 Å | Mutation | No | [1] |
PDB Sequence |
LCFKLYAKGK
649 HEKKTWFESR659 DFCRALGGDL669 ASINNKEEQQ679 TIWRLITASG689 SYHKLFWLGL 699 TYGSPSEGFT709 WSDGSPVSYE719 NWAYGEPNNY729 QNVEYCGELK739 GDPTMSWNDI 749 NCEHLNNWIC759 QI
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PDB ID: 7JUC C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside | ||||||
Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [1] |
PDB Sequence |
ACPEDWGAST
638 SLCFKLYAKG648 KHEKKTWFES658 RDFCRALGGD668 LASINNKEEQ678 QTIWRLITAS 688 GSYHKLFWLG698 LTYGSPSEGF708 TWSDGSPVSY718 ENWAYGEPNN728 YQNVEYCGEL 738 KGDPTMSWND748 INCEHLNNWI758 CQI
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PDB ID: 7JUD C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside | ||||||
Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [1] |
PDB Sequence |
LCFKLYAKGK
649 HEKKTWFESR659 DFCRALGGDL669 ASINNKEEQQ679 TIWRLITASG689 SYHKLFWLGL 699 TYGSPSEGFT709 WSDGSPVSYE719 NWAYGEPNNY729 QNVEYCGELK739 GDPTMSWNDI 749 NCEHLNNWIC759 QI
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References | Top | ||||
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REF 1 | Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J Biol Chem. 2021 Jan-Jun;296:100368. |
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