Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T20401 | ||||
Target Name | Carbonic anhydrase II | ||||
Target Type | Successful |
||||
Drug Potency against Target | MAFENIDE | Drug Info | Ki = 170 nM | [530765] | |
4,6-Dinitro salicylic acid | Drug Info | Ki = 5450 nM | [529721] | ||
2-methoxyestradiol 3,17-O,O-bis-sulfamate | Drug Info | IC50 = 379 nM | [529303] | ||
EMATE | Drug Info | IC50 = 42 nM | [528582] | ||
4-(2-Phenylacetamidomethyl)benzenesulfonamide | Drug Info | Ki = 54 nM | [530219] | ||
(2,2-dimethyl-1,3-dioxolan-4-yl)methyl sulfamate | Drug Info | Ki = 1020 nM | [528233] | ||
CATECHIN | Drug Info | Ki = 1840 nM | [531068] | ||
Octane-1,8-diyl disulfamate | Drug Info | Ki = 14.6 nM | [530359] | ||
Decyl sulfamate | Drug Info | Ki = 0.7 nM | [530359] | ||
4-(4-Fluorophenoxy)-3-pyridinesulfonamide | Drug Info | Ki = 94.4 nM | [530766] | ||
4-Ethoxy-3-pyridinesulfonamide | Drug Info | Ki = 76.7 nM | [530766] | ||
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide | Drug Info | Ki = 140 nM | [530766] | ||
4-(Quinolinoxy)-3-pyridinesulfonamide | Drug Info | Ki = 105 nM | [530766] | ||
5-Amino-[1,3,4]thiadiazole-2-thiol | Drug Info | Ki = 9200 nM | [527519] | ||
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide | Drug Info | Ki = 84.5 nM | [530766] | ||
2-methoxyestradiol-17-O-sulfamate | Drug Info | IC50 = 526 nM | [529303] | ||
2-methoxyestrrone-3-O-sulfamate | Drug Info | IC50 = 376 nM | [529303] | ||
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide | Drug Info | Ki = 16 nM | [529381] | ||
4-isothiocyanatobenzenesulfonamide | Drug Info | Ki = 185 nM | [527233] | ||
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide | Drug Info | Ki = 87 nM | [527338] | ||
5-amino-1,3,4-thiadiazole-2-sulfonamide | Drug Info | Ki = 7400 nM | [531112] | ||
Azide | Drug Info | Ki = 1.5 nM | [527231] | ||
Phenyl Boronic acid | Drug Info | Ki = 23.1 nM | [527231] | ||
Phenoxyarsonous acid | Drug Info | Ki = 49.2 nM | [527231] | ||
2,6-di-t-butylphenol | Drug Info | Ki = 510 nM | [529973] | ||
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide | Drug Info | Ki = 106 nM | [530292] | ||
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide | Drug Info | Ki = 77 nM | [530978] | ||
MMI270 | Drug Info | Ki = 8600 nM | [528653] | ||
2,4-Disulfamyltrifluoromethylaniline | Drug Info | Ki = 63 nM | [530466] | ||
SULFAMIDE | Drug Info | Ki = 1.13 nM | [527231] | ||
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide | Drug Info | Ki = 33 nM | [530466] | ||
3-phenylprop-1-enylboronic acid | Drug Info | Ki = 18100 nM | [530086] | ||
Di(2,6-dimethylphenol) | Drug Info | Ki = 4050 nM | [529973] | ||
PHENYLDIFLUOROMETHANESULFONAMIDE | Drug Info | Ki = 156 nM | [527782] | ||
Di(2,6-diisopropylphenol) | Drug Info | Ki = 1870 nM | [529973] | ||
PHENYLSULFAMIDE | Drug Info | Ki = 8020 nM | [528233] | ||
4-phenoxyphenylboronic acid | Drug Info | Ki = 11500 nM | [530086] | ||
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide | Drug Info | Ki = 46 nM | [530466] | ||
Phenethylboronic acid | Drug Info | Ki = 17900 nM | [530086] | ||
5-Chlorosalicylic Acid | Drug Info | Ki = 1270 nM | [529721] | ||
3-Nitro-benzenesulfonamide | Drug Info | IC50 = 410 nM | [527253] | ||
SULFAMATE | Drug Info | Ki = 0.39 nM | [527231] | ||
PARAOXON | Drug Info | IC50 = 59 nM | [531156] | ||
PHENOL | Drug Info | Ki = 5500 nM | [531068] | ||
N-hydroxysulfamide | Drug Info | Ki = 566 nM | [530922] | ||
4-bromophenylboronic acid | Drug Info | Ki = 7000 nM | [530086] | ||
GUAIACOL | Drug Info | Ki = 2940 nM | [529973] | ||
1-pentenyl-4-(aminosulfonyl)benzoate | Drug Info | Ki = 7.7 nM | [527786] | ||
2-acetamido-5-sulfonamidoindane | Drug Info | Ki = 1 nM | [528160] | ||
BENZOLAMIDE | Drug Info | Ki = 9 nM | [530466] | ||
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide | Drug Info | Ki = 701.8 nM | [530416] | ||
BUTYLATEDHYDROXYTOLUENE | Drug Info | Ki = 630 nM | [529973] | ||
4-Hydrazino-3-pyridinesulfonamide | Drug Info | Ki = 85.6 nM | [530766] | ||
P-TOLUENESULFONAMIDE | Drug Info | Ki = 320 nM | [530466] | ||
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide | Drug Info | Ki = 8800 nM | [527519] | ||
3-(4-sulfamoylphenyl)propanoic acid | Drug Info | Ki = 495 nM | [530466] | ||
4-Amino-3-bromo-benzenesulfonamide | Drug Info | Ki = 40 nM | [530466] | ||
2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide | Drug Info | Ki = 230 nM | [527743] | ||
2-Amino-benzenesulfonamide | Drug Info | Ki = 295 nM | [530466] | ||
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide | Drug Info | Ki = 80.4 nM | [530766] | ||
IODIDE | Drug Info | Ki = 26 nM | [527231] | ||
NITRATE | Drug Info | Ki = 35 nM | [527231] | ||
P-tolylboronic acid | Drug Info | Ki = 10800 nM | [530086] | ||
N-(pentafluorophenyl)sulfamide | Drug Info | Ki = 32 nM | [527520] | ||
2-Acetylamino-indan-5-sulfonic acid hydrate | Drug Info | Ki = 65 nM | [527262] | ||
Biphenyl-4-ylboronic acid | Drug Info | Ki = 4500 nM | [530086] | ||
1-pentafluorophenylamido-5-sulfonamidoindane | Drug Info | Ki = 490 nM | [528160] | ||
1-valproylamido-5-sulfonamidoindane | Drug Info | Ki = 1.2 nM | [528160] | ||
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info | Ki = 950 nM | [529794] | ||
2-ethylamido-5-sulfonamidoindane | Drug Info | Ki = 10 nM | [528160] | ||
4-butylphenylboronic acid | Drug Info | Ki = 8700 nM | [530086] | ||
1-cyclohexylamido-5-sulfonamidoindane | Drug Info | Ki = 32 nM | [528160] | ||
4-((benzylideneamino)methyl)benzenesulfonamide | Drug Info | Ki = 38.5 nM | [530416] | ||
4-(2-Propynylthio)pyridine-3-sulfonamide | Drug Info | Ki = 108 nM | [530766] | ||
N-(4-cyanophenyl)sulfamide | Drug Info | Ki = 16 nM | [527520] | ||
3-Fluoro-4-hydrazino-benzenesulfonamide | Drug Info | Ki = 51 nM | [527482] | ||
4-Hydrazino-benzenesulfonamide | Drug Info | Ki = 300 nM | [529948] | ||
(4-bromophenyl)difluoromethanesulfonamide | Drug Info | Ki = 98 nM | [527782] | ||
Sulfamic acid 3-sulfamoyloxy-phenyl ester | Drug Info | Ki = 9.4 nM | [527391] | ||
SACCHARIN | Drug Info | Ki = 5959 nM | [531031] | ||
PHENYLMETHANESULFONAMIDE | Drug Info | Ki = 645 nM | [527782] | ||
Sulfamic acid 12-sulfamoyloxy-dodecyl ester | Drug Info | Ki = 84.2 nM | [527391] | ||
2-Sulfamoyl-benzoic acid methyl ester | Drug Info | Ki = 420 nM | [527482] | ||
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide | Drug Info | Ki = 58 nM | [530219] | ||
2-(benzylideneamino)ethanesulfonamide | Drug Info | Ki = 160 nM | [530416] | ||
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid | Drug Info | Ki = 13400 nM | [530514] | ||
2-Amino-indan-5-sulfonic acid | Drug Info | Ki = 84 nM | [527262] | ||
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide | Drug Info | Ki = 53 nM | [530219] | ||
4-Benzythiopyridine-3-sulfonamide | Drug Info | Ki = 9.9 nM | [530766] | ||
2-(N''-Acetyl-hydrazino)-benzenesulfonamide | Drug Info | Ki = 264 nM | [527482] | ||
N-(4-Sulfamoyl-phenyl)-isobutyramide | Drug Info | Ki = 258 nM | [527743] | ||
3-Chloro-4-hydrazino-benzenesulfonamide | Drug Info | Ki = 76 nM | [527482] | ||
3-bromophenyl-difluoromethanesulfonamide | Drug Info | Ki = 565 nM | [527782] | ||
Sulfamic acid 6-sulfamoyloxy-hexyl ester | Drug Info | Ki = 8.3 nM | [527391] | ||
4-methyl-2-oxo-2H-chromen-7-yl sulfamate | Drug Info | Ki = 25 nM | [527782] | ||
4-(Allylamino)-3-pyridinesulfonamide | Drug Info | Ki = 133 nM | [530766] | ||
Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester | Drug Info | Ki = 643 nM | [527391] | ||
Allyl 4-(aminosulfonyl)benzoate | Drug Info | Ki = 8.6 nM | [527786] | ||
4-(2-Hydroxy-ethyl)-benzenesulfonamide | Drug Info | Ki = 125 nM | [531031] | ||
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester | Drug Info | Ki = 563 nM | [527391] | ||
2-nonylamido-5-sulfonamidoindane | Drug Info | Ki = 128 nM | [528160] | ||
4-(2-Phenylacetamidoethyl)benzenesulfonamide | Drug Info | Ki = 67 nM | [530219] | ||
4-(Cyanomethylthio)pyridine-3-sulfonamide | Drug Info | Ki = 91.1 nM | [530766] | ||
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide | Drug Info | Ki = 74 nM | [530219] | ||
4-[2-(2-Thienyl)acetamido]benzenesulfonamide | Drug Info | Ki = 50 nM | [530219] | ||
2,3-dihydro-1H-indene-5-sulfonamide | Drug Info | Ki = 52 nM | [527262] | ||
4-(benzylideneamino)benzenesulfonamide | Drug Info | Ki = 21.4 nM | [530416] | ||
Methyl 4-(4-hydroxybenzylideneamino)benzoate | Drug Info | Ki = 141.5 nM | [530416] | ||
4-(4-hydroxybenzylideneamino)benzoic acid | Drug Info | Ki = 200.5 nM | [530416] | ||
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info | Ki = 870 nM | [529794] | ||
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide | Drug Info | Ki = 4800 nM | [528653] | ||
3-((4-aminophenyl)diazenyl)benzenesulfonamide | Drug Info | Ki = 88 nM | [530292] | ||
2-(4-hydroxybenzylideneamino)ethanesulfonamide | Drug Info | Ki = 236 nM | [530416] | ||
N-[4-(trifluoromethyl)phenyl]sulfamide | Drug Info | Ki = 7000 nM | [527520] | ||
Quinoline-8-sulfonamide | Drug Info | Ki = 125 nM | [529884] | ||
4-nitrophenylsulfamide | Drug Info | Ki = 1740 nM | [528233] | ||
4-(benzylideneamino)benzoic acid | Drug Info | Ki = 123.2 nM | [530416] | ||
N-1,3,4-thiadiazol-2-ylsulfamide | Drug Info | Ki = 970 nM | [529794] | ||
INDISULAM | Drug Info | Ki = 15 nM | [530978] | ||
4-Benzenesulfonylamino-benzenesulfonamide | Drug Info | Ki = 49 nM | [527743] | ||
4-Amino-3-fluoro-benzenesulfonamide | Drug Info | Ki = 60 nM | [531031] | ||
4-amino-6-chlorobenzene-1,3-disulfonamide | Drug Info | Ki = 75 nM | [531031] | ||
2,6-di-tert-butyl-4-methoxyphenol | Drug Info | Ki = 420 nM | [529973] | ||
Ethinamate | Drug Info | IC50 = 0.6~2.5 g/ml | [536068] | ||
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide | Drug Info | Ki = 100 nM | [529884] | ||
4-Amino-3-iodo-benzenesulfonamide | Drug Info | Ki = 70 nM | [530466] | ||
4-(4-tert-butylbenzylideneamino)benzoic acid | Drug Info | Ki = 184.5 nM | [530416] | ||
1,4-phenylene disulfamate | Drug Info | Ki = 643 nM | [529884] | ||
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide | Drug Info | Ki = 106 nM | [530292] | ||
Methyl-phosphonic acid | Drug Info | Ki = 98 nM | [527462] | ||
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide | Drug Info | Ki = 920 nM | [529794] | ||
COUMATE | Drug Info | Ki = 21 nM | [529605] | ||
6-hydroxybenzo[d][1,3]oxathiol-2-one | Drug Info | IC50 = 1770 nM | [529555] | ||
SALICYLATE | Drug Info | Ki = 7100 nM | [529562] | ||
N-(1-benzofuran-3-ylmethyl)sulfamide | Drug Info | IC50 = 7100 nM | [530089] | ||
2-(4-tert-butylbenzylideneamino)ethanesulfonamide | Drug Info | Ki = 8.6 nM | [530416] | ||
Methyl 4-(4-tert-butylbenzylideneamino)benzoate | Drug Info | Ki = 158.4 nM | [530416] | ||
PHENYLSULFAMATE | Drug Info | Ki = 36 nM | [528233] | ||
4-(N-Methyl-hydrazino)-benzenesulfonamide | Drug Info | Ki = 300 nM | [527407] | ||
4-methoxyphenylboronic acid | Drug Info | Ki = 7900 nM | [530086] | ||
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide | Drug Info | Ki = 5 nM | |||
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide | Drug Info | Ki = 31 nM | [530132] | ||
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide | Drug Info | Ki = 80 nM | [530978] | ||
4-Nitro-benzenesulfonamide | Drug Info | IC50 = 400 nM | [527253] | ||
NSC-654077 | Drug Info | Ki = 4975 nM | [529381] | ||
4-nitrophenyl phosphate | Drug Info | IC50 = 63 nM | [531156] | ||
6-Nitro-benzothiazole-2-sulfonic acid amide | Drug Info | IC50 = 250 nM | [527253] | ||
SPARFOSIC ACID | Drug Info | Ki = 7800 nM | [527462] | ||
Phenyl-phosphonic acid | Drug Info | Ki = 99 nM | [527462] | ||
Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester | Drug Info | IC50 = 280 nM | [527479] | ||
Sulfamic acid chroman-2-ylmethyl ester | Drug Info | IC50 = 130 nM | [527479] | ||
4-(2-Amino-ethyl)-benzenesulfonamide | Drug Info | Ki = 160 nM | [527645] | ||
Decane-1,10-diyl disulfamate | Drug Info | Ki = 24.5 nM | [530359] | ||
CHLORIDE | Drug Info | Ki = 200 nM | [527231] | ||
Curcumin | Drug Info | Ki = 380 nM | [531068] | ||
PARABEN | Drug Info | Ki = 870 nM | [530751] | ||
Syringic Acid | Drug Info | Ki = 3190 nM | [530751] | ||
P-Coumaric Acid | Drug Info | Ki = 980 nM | [530751] | ||
Octyl sulfamate | Drug Info | Ki = 2.7 nM | [530359] | ||
4-methoxyphenylsulfamide | Drug Info | Ki = 18800 nM | [528233] | ||
3-hydroxy-2-methoxybenzaldehyde | Drug Info | Ki = 1250 nM | [529973] | ||
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide | Drug Info | Ki = 27 nM | [528406] | ||
Di(2,6-di-t-butylphenol) | Drug Info | Ki = 290 nM | [529973] | ||
6-Amino-benzothiazole-2-sulfonic acid amide | Drug Info | Ki = 9 nM | [525539] | ||
SODIUM PERFLUOROHEXANESULFONAMIDE | Drug Info | IC50 = 122 nM | [530602] | ||
4-azidobenzenesulfonamide | Drug Info | Ki = 47 nM | [529609] | ||
Sodium trithiocarbonate | Drug Info | Ki = 8800 nM | [530003] | ||
4-ethynyl benzene sulfonamide | Drug Info | Ki = 5.1 nM | [529344] | ||
N-propynyl amidebenzenesulphonide | Drug Info | Ki = 47 nM | [528491] | ||
4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide | Drug Info | Ki = 665 nM | [530292] | ||
PRONTOCIL | Drug Info | Ki = 13000 nM | [530292] | ||
FERULIC ACID | Drug Info | Ki = 2400 nM | [530751] | ||
3-Amino-benzenesulfonamide | Drug Info | Ki = 240 nM | [527415] | ||
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide | Drug Info | Ki = 1130 nM | [529794] | ||
4-(hydroxymethyl)benzenesulfonamide | Drug Info | Ki = 80 nM | [530466] | ||
4-Amino-3-chloro-benzenesulfonamide | Drug Info | Ki = 110 nM | [530466] | ||
6-methyl-2-oxo-2H-chromene-3-carboxylic acid | Drug Info | Ki = 9100 nM | [530514] | ||
RESORCINOL | Drug Info | Ki = 7700 nM | [529562] | ||
CATECHOL | Drug Info | Ki = 9900 nM | [530751] | ||
4-CYANOPHENOL | Drug Info | Ki = 108 nM | [529562] | ||
Beta-naphthylboronic acid | Drug Info | Ki = 6000 nM | [530086] | ||
4-Thiocyanato-benzenesulfonamide | Drug Info | IC50 = 3600 nM | [527253] | ||
6-Hydroxy-benzothiazole-2-sulfonic acid amide | Drug Info | Ki = 30 nM | [529948] | ||
2-hydrazinylbenzenesulfonamide | Drug Info | Ki = 125 nM | [537461] | ||
Carzenide | Drug Info | Ki = 151 nM | [527786] | ||
4-nitrophenyl-difluoromethanesulfonamide | Drug Info | Ki = 113 nM | [527782] | ||
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info | Ki = 900 nM | [529794] | ||
2-oxo-2H-thiochromene-3-carboxylic acid | Drug Info | Ki = 7800 nM | [530514] | ||
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide | Drug Info | Ki = 61 nM | [530219] | ||
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide | Drug Info | Ki = 69 nM | [530219] | ||
4-(2-Phenylacetamido)benzenesulfonamide | Drug Info | Ki = 107 nM | [530219] | ||
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide | Drug Info | Ki = 395 nM | [530219] | ||
Aminobenzolamide derivative | Drug Info | Ki = 0.9 nM | [527261] | ||
ELLAGIC ACID | Drug Info | Ki = 2180 nM | [530751] | ||
4-(Carbamolymethylthio)pyridine-3-sulfonamide | Drug Info | Ki = 131 nM | [530766] | ||
GALLICACID | Drug Info | Ki = 2250 nM | [530751] | ||
Pentanoic acid (4-sulfamoyl-phenyl)-amide | Drug Info | Ki = 214 nM | [527743] | ||
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide | Drug Info | Ki = 7.5 nM | [527262] | ||
ACETYLSULFANILAMIDE | Drug Info | Ki = 246 nM | [527743] | ||
4-methylphenyl-difluoromethanesulfonamide | Drug Info | Ki = 348 nM | [527782] | ||
4-(Methylhydrazino)-3-pyridinesulfonamide | Drug Info | Ki = 87.2 nM | [530766] | ||
2-cyclohexylamido-5-sulfonamidoindane | Drug Info | Ki = 118 nM | [528160] | ||
2-butylamido-5-sulfonamidoindane | Drug Info | Ki = 7.5 nM | [528160] | ||
2-propylamido-5-sulfonamidoindane | Drug Info | Ki = 46 nM | [528160] | ||
2-valproylamido-5-sulfonamidoindane | Drug Info | Ki = 0.9 nM | [528160] | ||
1-(3,4-dichlorophenyl)-3-hydroxyurea | Drug Info | Ki = 310 nM | [528240] | ||
Prop-2-ynyl 4-sulfamoylbenzoate | Drug Info | Ki = 45 nM | [528491] | ||
1-acetamido-5-sulfonamidoindane | Drug Info | Ki = 186 nM | [528160] | ||
4-Methanesulfonylamino-benzenesulfonamide | Drug Info | Ki = 64 nM | [527743] | ||
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide | Drug Info | Ki = 4700 nM | [528653] | ||
2-Hydrazinocarbonyl-benzenesulfonamide | Drug Info | Ki = 338 nM | [527482] | ||
COUMARIN | Drug Info | Ki = 9200 nM | [531259] | ||
4-(4-Cyanophenoxy)-3-pyridinesulfonamide | Drug Info | Ki = 94.5 nM | [530766] | ||
Sulfamic acid 7-sulfamoyloxy-heptyl ester | Drug Info | Ki = 8 nM | [527391] | ||
(2-bromophenyl)difluoromethanesulfonamide | Drug Info | Ki = 112 nM | [527782] | ||
4-Methylthiopyridine-3-sulfonamide | Drug Info | Ki = 40.1 nM | [530766] | ||
N-(4-Sulfamoyl-phenyl)-butyramide | Drug Info | Ki = 227 nM | [527743] | ||
Sulfamic acid 4-sulfamoyloxy-butyl ester | Drug Info | Ki = 15 nM | [527391] | ||
2-pentafluorophenylamido-5-sulfonamidoindane | Drug Info | Ki = 6.7 nM | [528160] | ||
6-(aminomethyl)-2H-chromen-2-one | Drug Info | Ki = 18500 nM | [530514] | ||
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide | Drug Info | Ki = 6100 nM | [528653] | ||
2-(benzyloxyamino)-N-hydroxyhexanamide | Drug Info | Ki = 7800 nM | [528653] | ||
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide | Drug Info | Ki = 75 nM | [527743] | ||
4-Methoxy-3-pyridinesulfonamide | Drug Info | Ki = 93.8 nM | [530766] | ||
N-(4-Sulfamoyl-phenyl)-benzamide | Drug Info | Ki = 37 nM | [527743] | ||
Pentane-1,5-diamine | Drug Info | Ki = 11000 nM | [530998] | ||
2,4-dichloro-5-sulfamoylbenzoic acid | Drug Info | IC50 = 18000 nM | [530578] | ||
Sodium 2,3,5,6-tetrafluorobenzoate | Drug Info | Ki = 6000 nM | [530027] | ||
2-Hydroxycinnamic acid | Drug Info | Ki = 9200 nM | [531068] | ||
6-(hydroxymethyl)-2H-chromen-2-one | Drug Info | Ki = 19200 nM | [530514] | ||
3-(3-Phenyl-ureido)-benzenesulfonamide | Drug Info | Ki = 150 nM | [527743] | ||
N-(4-Sulfamoyl-phenyl)-propionamide | Drug Info | Ki = 232 nM | [527743] | ||
Benzothiazole-2-sulfonic acid amide | Drug Info | Ki = 30 nM | [527408] | ||
N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide | Drug Info | IC50 = 3700 nM | [530089] | ||
N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide | Drug Info | IC50 = 8400 nM | [530089] | ||
4-Methylamino-benzenesulfonamide | Drug Info | Ki = 240 nM | [527407] | ||
4,4'-thiodipyridine-3-sulfonamide | Drug Info | Ki = 65 nM | [530766] | ||
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one | Drug Info | Ki = 14600 nM | [530979] | ||
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide | Drug Info | Ki = 133 nM | [527743] | ||
References | |||||
Ref 530765 | J Med Chem. 2010 Apr 8;53(7):2913-26.Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. | ||||
Ref 529721 | Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. Epub 2008 Sep 13.In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. | ||||
Ref 529303 | J Med Chem. 2008 Mar 13;51(5):1295-308. Epub 2008 Feb 9.Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. | ||||
Ref 528582 | J Med Chem. 2006 Dec 28;49(26):7683-96.2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 528233 | J Med Chem. 2006 Jun 15;49(12):3496-500.Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. | ||||
Ref 531068 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. | ||||
Ref 530359 | J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. | ||||
Ref 530359 | J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527519 | Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 529303 | J Med Chem. 2008 Mar 13;51(5):1295-308. Epub 2008 Feb 9.Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. | ||||
Ref 529303 | J Med Chem. 2008 Mar 13;51(5):1295-308. Epub 2008 Feb 9.Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. | ||||
Ref 529381 | J Med Chem. 2008 Jun 12;51(11):3051-6. Epub 2008 Mar 19.Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. | ||||
Ref 527233 | J Med Chem. 2004 Oct 7;47(21):5224-9.Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. | ||||
Ref 527338 | Bioorg Med Chem Lett. 2005 Jan 17;15(2):367-72.Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX. | ||||
Ref 531112 | Eur J Med Chem. 2010 Nov;45(11):4769-73. Epub 2010 Jul 24.Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 529973 | Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. | ||||
Ref 530292 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. Epub 2009 Jul 22.Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. | ||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
Ref 528653 | Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 529973 | Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 529973 | Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. | ||||
Ref 528233 | J Med Chem. 2006 Jun 15;49(12):3496-500.Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 529721 | Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. Epub 2008 Sep 13.In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. | ||||
Ref 527253 | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 531156 | Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases. | ||||
Ref 531068 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. | ||||
Ref 530922 | Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. Epub 2010 Apr 28.Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 529973 | Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. | ||||
Ref 527786 | Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33. Epub 2005 Oct 6.Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 529973 | Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 527519 | Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 527520 | Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527520 | Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors. | ||||
Ref 527482 | J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties. | ||||
Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 531031 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 527482 | J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527482 | J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 527482 | J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 527786 | Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33. Epub 2005 Oct 6.Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. | ||||
Ref 531031 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 528653 | Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates. | ||||
Ref 530292 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. Epub 2009 Jul 22.Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 527520 | Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors. | ||||
Ref 529884 | Bioorg Med Chem. 2009 Jan 15;17(2):553-7. Epub 2008 Dec 6.Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. | ||||
Ref 528233 | J Med Chem. 2006 Jun 15;49(12):3496-500.Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 531031 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. | ||||
Ref 531031 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. | ||||
Ref 529973 | Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. | ||||
Ref 536068 | The magic bullets and tuberculosis drug targets. Annu Rev Pharmacol Toxicol. 2005;45:529-64. | ||||
Ref 529884 | Bioorg Med Chem. 2009 Jan 15;17(2):553-7. Epub 2008 Dec 6.Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 529884 | Bioorg Med Chem. 2009 Jan 15;17(2):553-7. Epub 2008 Dec 6.Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. | ||||
Ref 530292 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. Epub 2009 Jul 22.Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. | ||||
Ref 527462 | Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 529605 | Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. Epub 2008 Jul 5.Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. | ||||
Ref 529555 | Bioorg Med Chem Lett. 2008 Jul 15;18(14):3938-41. Epub 2008 Jun 12.Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?. | ||||
Ref 529562 | Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. | ||||
Ref 530089 | J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 530416 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. | ||||
Ref 528233 | J Med Chem. 2006 Jun 15;49(12):3496-500.Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. | ||||
Ref 527407 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 530132 | J Med Chem. 2009 Jul 9;52(13):4063-7.Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. | ||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
Ref 527253 | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. | ||||
Ref 529381 | J Med Chem. 2008 Jun 12;51(11):3051-6. Epub 2008 Mar 19.Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. | ||||
Ref 531156 | Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases. | ||||
Ref 527253 | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. | ||||
Ref 527462 | Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. | ||||
Ref 527462 | Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. | ||||
Ref 527479 | J Med Chem. 2005 Mar 24;48(6):1941-7.Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. | ||||
Ref 527479 | J Med Chem. 2005 Mar 24;48(6):1941-7.Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. | ||||
Ref 527645 | J Med Chem. 2005 Jul 28;48(15):4834-41.Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. | ||||
Ref 530359 | J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. | ||||
Ref 527231 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. | ||||
Ref 531068 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 530359 | J Med Chem. 2009 Oct 8;52(19):5990-8.Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. | ||||
Ref 528233 | J Med Chem. 2006 Jun 15;49(12):3496-500.Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. | ||||
Ref 529973 | Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. | ||||
Ref 528406 | J Med Chem. 2006 Sep 7;49(18):5544-51.Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. | ||||
Ref 529973 | Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. | ||||
Ref 525539 | J Med Chem. 1999 Jul 15;42(14):2641-50.Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?. | ||||
Ref 530602 | Eur J Med Chem. 2010 Mar;45(3):1225-9. Epub 2009 Dec 5.Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase. | ||||
Ref 529609 | Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. Epub 2008 Jul 10.Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. | ||||
Ref 530003 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7. Epub 2009 Feb 26.Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. | ||||
Ref 529344 | J Med Chem. 2008 Mar 27;51(6):1945-53. Epub 2008 Feb 29.Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. | ||||
Ref 528491 | J Med Chem. 2006 Nov 2;49(22):6539-48.A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". | ||||
Ref 530292 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. Epub 2009 Jul 22.Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. | ||||
Ref 530292 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. Epub 2009 Jul 22.Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 527415 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 529562 | Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 529562 | Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. Epub 2008 Jun 13.Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. | ||||
Ref 530086 | Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. | ||||
Ref 527253 | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. | ||||
Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
Ref 527786 | Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33. Epub 2005 Oct 6.Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 529794 | Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 530219 | Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. Epub 2009 Jun 9.Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. | ||||
Ref 527261 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530751 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 528240 | Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. Epub 2006 Jun 12.N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. | ||||
Ref 528491 | J Med Chem. 2006 Nov 2;49(22):6539-48.A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 528653 | Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates. | ||||
Ref 527482 | J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties. | ||||
Ref 531259 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 527782 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. Epub 2005 Oct 3.Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 527391 | Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. | ||||
Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 528653 | Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates. | ||||
Ref 528653 | Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 530998 | J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. | ||||
Ref 530578 | Bioorg Med Chem. 2010 Jan 15;18(2):930-8. Epub 2009 Nov 20.Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex. | ||||
Ref 530027 | Bioorg Med Chem. 2009 Apr 1;17(7):2654-7. Epub 2009 Mar 5.Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates. | ||||
Ref 531068 | Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. Epub 2010 Jul 13.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. | ||||
Ref 530514 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. | ||||
Ref 527408 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6.Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. | ||||
Ref 530089 | J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. | ||||
Ref 530089 | J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. | ||||
Ref 527407 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. | ||||
Ref 530766 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. | ||||
Ref 530979 | Bioorg Med Chem. 2010 Jun 15;18(12):4468-74. Epub 2010 May 28.A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. | ||||
Ref 527743 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. |
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