| Drug General Information |
| Drug ID |
D0Z6TM
|
| Former ID |
DNC007170
|
| Drug Name |
4-azidobenzenesulfonamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C6H6N4O2S
|
| Canonical SMILES |
C1=CC(=CC=C1N=[N+]=[N-])S(=O)(=O)N
|
| InChI |
1S/C6H6N4O2S/c7-10-9-5-1-3-6(4-2-5)13(8,11)12/h1-4H,(H2,8,11,12)
|
| InChIKey |
UZEFHQIOSJWWSB-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase II |
Target Info |
Inhibitor |
[2]
|
|---|
| Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase I |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
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Nitrogen metabolism
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Proximal tubule bicarbonate reclamation
|
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Collecting duct acid secretion
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Gastric acid secretion
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Pancreatic secretion
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Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
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NetPath Pathway
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IL4 Signaling Pathway
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EGFR1 Signaling Pathway
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Pathway Interaction Database
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HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
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PathWhiz Pathway
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Gastric Acid Production
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Reactome
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Erythrocytes take up carbon dioxide and release oxygen
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Erythrocytes take up oxygen and release carbon dioxide
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Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
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Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
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Reversible hydration of carbon dioxide
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WikiPathways
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Reversible Hydration of Carbon Dioxide
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
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Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2009 Apr 15;19(8):2273-6. Epub 2009 Feb 26.Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. Epub 2008 Jul 10.Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. |
|---|
