Drug Information
Drug General Information | |||||
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Drug ID |
D0BD0K
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Former ID |
DNC010196
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Drug Name |
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide
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Synonyms |
4-((4-aminophenyl)diazenyl)benzenesulfonamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [530399] | ||
Structure |
Download2D MOL |
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Formula |
C12H12N4O2S
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Canonical SMILES |
C1=CC(=CC=C1N)N=NC2=CC=C(C=C2)S(=O)(=O)N
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InChI |
1S/C12H12N4O2S/c13-9-1-3-10(4-2-9)15-16-11-5-7-12(8-6-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)
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InChIKey |
JSHXITVMUADQEA-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Carbonic anhydrase IX | Target Info | Inhibitor | [530399] | |
Carbonic anhydrase II | Target Info | Inhibitor | [530292] | ||
Carbonic anhydrase XII | Target Info | Inhibitor | [530399] | ||
Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
Reactome | Regulation of gene expression by Hypoxia-inducible Factor | ||||
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Erythrocytes take up oxygen and release carbon dioxide | |||||
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide | |||||
WikiPathways | Vitamin D Receptor Pathway | ||||
Reversible Hydration of Carbon Dioxide | |||||
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBase | |||||
References | |||||
Ref 530292 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. Epub 2009 Jul 22.Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. | ||||
Ref 530399 | Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. Epub 2009 Sep 6.Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XIIover the cytosolic isoforms I and II. |
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