Drug Information
Drug General Information | |||||
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Drug ID |
D09PWX
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Former ID |
DNC004667
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Drug Name |
Carzenide
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Synonyms |
Para-Carboxybenzenesulfonamide (Weak Carbonic Anhydrase Inhibitor)
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529948] | ||
Structure |
Download2D MOL |
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Formula |
C7H7NO4S
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Canonical SMILES |
C1=CC(=CC=C1C(=O)O)S(=O)(=O)N
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InChI |
1S/C7H7NO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)(H2,8,11,12)
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InChIKey |
UCAGLBKTLXCODC-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Carbonic anhydrase XIV | Target Info | Inhibitor | [527654] | |
Carbonic anhydrase IX | Target Info | Inhibitor | [529948] | ||
Carbonic anhydrase VI | Target Info | Inhibitor | [529948] | ||
Carbonic anhydrase XII | Target Info | Inhibitor | [527407] | ||
Carbonic anhydrase II | Target Info | Inhibitor | [527786] | ||
Carbonic anhydrase | Target Info | Inhibitor | [529948] | ||
Carbonic anhydrase I | Target Info | Inhibitor | [530046] | ||
KEGG Pathway | Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism | ||||
Proximal tubule bicarbonate reclamation | |||||
Collecting duct acid secretion | |||||
Gastric acid secretion | |||||
Pancreatic secretion | |||||
Bile secretionhsa00910:Nitrogen metabolism | |||||
Pathway Interaction Database | HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network | ||||
PathWhiz Pathway | Gastric Acid Production | ||||
Reactome | Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | ||||
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Erythrocytes take up oxygen and release carbon dioxide | |||||
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Reversible hydration of carbon dioxide | |||||
WikiPathways | Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway | ||||
Reversible Hydration of Carbon Dioxide | |||||
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
References | |||||
Ref 527407 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. | ||||
Ref 527654 | Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. | ||||
Ref 527786 | Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33. Epub 2005 Oct 6.Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. | ||||
Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
Ref 530046 | Nat Chem Biol. 2009 May;5(5):341-3. Epub 2009 Mar 29.Ligand-directed tosyl chemistry for protein labeling in vivo. |
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