| Drug General Information |
| Drug ID |
D0S2II
|
| Former ID |
DNC008205
|
| Drug Name |
4-(benzylideneamino)benzenesulfonamide
|
| Synonyms |
4-benzylideneamino-benzenesulfonamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H12N2O2S
|
| Canonical SMILES |
C1=CC=C(C=C1)C=NC2=CC=C(C=C2)S(=O)(=O)N
|
| InChI |
1S/C13H12N2O2S/c14-18(16,17)13-8-6-12(7-9-13)15-10-11-4-2-1-3-5-11/h1-10H,(H2,14,16,17)
|
| InChIKey |
OPUFYXLEFFRGSQ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase II |
Target Info |
Inhibitor |
[2]
|
|---|
| Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
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Aspirin triggered resolvin D biosynthesis
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C20 prostanoid biosynthesis
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Aspirin triggered resolvin E biosynthesis
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KEGG Pathway
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Nitrogen metabolism
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Proximal tubule bicarbonate reclamation
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Collecting duct acid secretion
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Gastric acid secretion
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Pancreatic secretion
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Bile secretionhsa00590:Arachidonic acid metabolism
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Metabolic pathways
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NF-kappa B signaling pathway
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VEGF signaling pathway
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TNF signaling pathway
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Retrograde endocannabinoid signaling
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Serotonergic synapse
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
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Leishmaniasis
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Pathways in cancer
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Chemical carcinogenesis
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MicroRNAs in cancer
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Small cell lung cancer
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NetPath Pathway
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IL4 Signaling Pathway
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EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
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TSH Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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IL5 Signaling Pathway
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PANTHER Pathway
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Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Toll receptor signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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S1P1 pathway
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C-MYB transcription factor network
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Signaling mediated by p38-alpha and p38-beta
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
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Arachidonic Acid Metabolism
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Reactome
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Erythrocytes take up carbon dioxide and release oxygen
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Erythrocytes take up oxygen and release carbon dioxide
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Reversible hydration of carbon dioxide
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WikiPathways
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Reversible Hydration of Carbon Dioxide
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP98:Prostaglandin Synthesis and Regulation
|
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Arachidonic acid metabolism
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Aryl Hydrocarbon Receptor
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Eicosanoid Synthesis
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Selenium Micronutrient Network
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| References |
| REF 1 | Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. Epub 2007 Nov 17.Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. |
|---|
